Results 61 to 70 of about 180,060 (255)
Advanced Science, EarlyView.Full androgen deprivation (FAD) induces paracrine cholesterol in prostate cancer that drives the polarization of cancer‐associated fibroblasts (CAFs) and subsequent elevated matrix stiffness. Matrix stiffness in turn potentiates tumor cell survival under FAD pressure via dual mechanotransductive activation of the IRE1α‐XBP1s stress‐response axis ...
Shaojie Liu +20 more
wiley +1 more source
Coping facilitators of health care professionals in the Iran-Iraq war: A qualitative study [PDF]
فصلنامه ابن سینا, 2015 Background: Attendance at war and its unusual circumstances is stressful for many people, including health care providers. So far, the process of coping and its facilitators in stressful condition of crisis has not been identified in healthcare providers.
Z Farsi, N Dehghan Nayeri
doaj
Designer Dynamic DNA Nanoaggregate in Living Cell for Mitochondrial Energy Restriction
Advanced Science, EarlyView.This study presents the Tech‐tetrahedron, a designer dynamic DNA nanoaggregate engineered for precise mitochondrial energy restriction. Its trinity‐functionalized design integrates navigable unit, telomerase‐activated latch, and self‐assembly module.
Ruijia Deng +12 more
wiley +1 more source
Frontiers in Physiology, 2018 Purpose: Blood biomarkers are a useful tool to study concussion. However, their interpretation is complicated by a number of potential biological confounds, including exercise.
Alex P. Di Battista +9 more
doaj +1 more source
Advanced Science, EarlyView.A fully synthetic four‐component vaccine has been developed combining Tn antigen, vizantin (Mincle agonist), rhamnose (antibody recruitment), and mannose (CD206 targeting). By synergistically activating Mincle, FcγR, and CD206 pathways, it elicits strong IgG switching and cytotoxic T‐cells, significantly inhibiting tumors in mice.
Wenbo Ming +9 more
wiley +1 more source
Intra-Operative Discomfort in Photorefractive Keratectomy
Clinical Ophthalmology, 2021 Samuel M Philbrick,1 John L Bennion2 1Department of Operational and Readiness Medicine, Joint Base Elmendorf-Richardson Hospital, Elmendorf, AK, USA; 2Department of Ophthalmology, Saint Alphonsus Health System, Boise, ID, USACorrespondence: Samuel M ...
Philbrick SM, Bennion JL
doaj
Observations from the Korean War for Modern Military Medicine. [PDF]
Uisahak, 2023 Bricknell MC.
europepmc +1 more source
Advanced Science, EarlyView.This study reveals a novel GC therapy targeting cholesterol homeostasis. Inhibiting the SCAP sterol‐sensing domain causes lethal ER stress via cholesterol accumulation, paradoxically forcing continuous synthesis that triggers ferroptosis. The findings link sterol sensing, metabolic dysregulation, and ferroptosis, establishing an anti‐cancer paradigm ...
Qianqian Xu +17 more
wiley +1 more source
What shapes cadets’ decisions? Factors influencing the choice of the Faculty of Medicine of the Military Medical Academy [PDF]
Vojnosanitetski PregledBackground/Aim. To create an effective promotional strategy for the Medical Faculty of the Military Medical Academy (MF MMA), it is essential to understand why young people decide to enroll in this military higher education institution (MHEI). The aim of
Petrović Aleksandar +2 more
doaj +1 more source
REGγ Suppresses Ferroptosis and Induces Drug Resistance by Degrading WDR6 in Chondrosarcoma
Advanced Science, EarlyView.Here, we identified REGγ as a susceptibility factor in chondrosarcoma. Our study demonstrates that abnormally activated REGγ‐20S proteasome promotes chondrosarcoma development and progression. Further validation in animal models revealed that blocking REGγ function induced ferroptosis, suppressed malignant progression of chondrosarcoma, and uncovered a
Fanrong Liu +20 more
wiley +1 more source