Results 61 to 70 of about 20,186 (258)

Matrix Rigidity Mechanoprimes Microglia for Inflammation Through Cytoskeletal‐to‐Nuclear Signaling and 3D Spatio‐Epigenomic Remodeling

Advanced Science, EarlyView.
Pathological tissue rigidity mechanoprimes microglia by enhancing actin cytoskeleton–nucleus coupling and chromatin opening at rigidity‐responsive cis‐regulatory elements (mechanoCREs). Subsequent NF‐κB/p65 signaling converges on this permissive regulatory state to amplify inflammatory gene expression and microglial activation.
Yu Xuan Meng, Jaegeon Joo, Yu Meng Li, Cheng Ji Li, Ali Taghizadeh, Seung Jae Shin, Buuvee Bayarkhangai, Tae‐Woo Ha, Sak Lee, Jaewoo Chung, Bo‐Eun Yoon, Hye Sung Kim, Inkyung Jung, Jung‐Hwan Lee, Kam W. Leong, Hae‐Won Kim   +15 more
wiley   +1 more source

Method for automatic reorganization of the structure of multi-agent systems, based on the application of the simulated hardening algorithm

Известия высших учебных заведений. Поволжский регион:Технические науки
Background. The organizational structure of a multi-agent system includes many roles of agents, their horizontal and vertical connections, components that control their behavior, as well as rules for their functioning.
Yu.V. Dubenko, E.E. Dyshkant, A.A. Obozovskiy   +2 more
doaj   +1 more source

The Limits of Legal Regulation of Military Relations

Сибирское юридическое обозрение
The paper deals with one of the key features of the regulation of legal relations in the military environment. Those are the detailed regulation of rights, responsibilities, the execution of assigned tasks and orders. The author sees the reasons for such
E. A. Glukhov
doaj   +1 more source

A Real‐Data‐Driven Framework for Evaluating Differential Transcript Usage Methods Across Long‐Read Bulk, Single‐Cell, and Spatial Transcriptomics

Advanced Science, EarlyView.
Grounded in real biological RNA‐seq data, the framework benchmarks ten differential transcript usage (DTU) methods across short‐read bulk, long‐read bulk, long‐read single‐cell, and long‐read spatial transcriptomics. By integrating reference transcript sets with ranked DTU results, the Transcript Set Enrichment Score (TSES) identifies data‐type ...
Chenxing Zhang, Jun Liu, Qi Zhao, Huilong Yin, Angang Yang, Minhua Zheng, Rui Zhang   +6 more
wiley   +1 more source

As Ordens Militares em combate nos finais da Idade Média: o caso da Guerra da Sucessão de Castela (1475-1479)

Medievalista, 2016
In the late fifteenth century, distant was the context of the emergence of the Military Orders, which occurred in the Classic Middle Ages, when Cluny diffused the ideal of a strong monasticism, chivalry was established as christianized group and the ...
António Carlos Martins Costa
doaj   +1 more source

Acid‐Responsive Nanobot‐Integrated Core‐Shell Microneedles Reprogram the Degenerative Annulus Fibrosus Microenvironment Through Epigenetic Suppression of Ferroptosis

Advanced Science, EarlyView.
An acid‐responsive core‐shell microneedle system normalizes the degenerative annulus fibrosus microenvironment by consuming pathological H+, generating O2, and providing NIR‐amplified redox buffering. Mechanistically, it epigenetically suppresses ferroptosis via DNMT3A‐dependent methylation of the ATF3 promoter, relieving ATF3‐mediated repression of ...
Lu Tan, Yan Zheng, Yue Lan, Zhuo Cheng, Siya Wang, Changqing Li, Yanqiu Wang, Minghan Liu   +7 more
wiley   +1 more source

A Hepatocyte‐to‐Stellate Cell Axis Couples Alternate‐Day Fasting to Liver Fibrosis Resolution via ATG7 S‐Nitrosylation

Advanced Science, EarlyView.
Alternate‐day fasting suppresses mitochondrial complex II assembly via SDHAF4 to upregulate hepatocyte eNOS. The resulting nitric oxide S‐nitrosylates ATG7 at C184 in hepatic stellate cells, restraining autophagic flux and preventing their profibrotic activation.
Xueqiang Wang, Mengqi Zeng, Cunxiao Sun, Yuhan Gou, Zhaode Feng, Weiqiang Lv, Chaoying Yan, Hansen Wu, Pengfei Zhang, Jie Xu, Ke Cao, Hao Li, Mingge Ding, Zhongbo Liu, Xing Zhang, Jiankang Liu, Xuan Zou, Zhihui Feng   +17 more
wiley   +1 more source

Low‐Intensity Ultrasound‐Triggered Microbubble Cavitation Attenuates Diabetic Kidney Injury Partially by Reversing Endothelial Dysfunction

Advanced Science, EarlyView.
Non‐invasive low‐intensity pulsed ultrasound ‐triggered cavitation of clinically approved diagnostic‐grade microbubbles delivers favorable mechanical stimuli to renal microvasculature. This intervention restores renal microvascular homeostasis, alleviates DKD‐associated histological and functional damage, and suppresses inflammatory and fibrotic ...
Yubo Lai, Liang Zhang, Wenxin Tao, Jieyuan An, Lantian Wang, Zhaoyou Liu, Guodong Yang, Pengying Wu, Lijun Yuan   +8 more
wiley   +1 more source

Las Órdenes Militares en el Reino de Sevilla en la Edad Media [PDF]

Historia. Instituciones. Documentos, 2012
A vision of the military orders participation in the conquest of the Kingdom of Seville, of the causes of their scarce territorial resources and of the system change after the Moorish rebellion in 1264 and the benimerin invasion.
Daniel Rodríguez Blanco
doaj  

Los fines de la presencia de la Orden del Hospital en Castilla (Siglos XII y XIII)

Espacio, Tiempo y Forma. Serie III, Historia Medieval, 2015
Las fuentes nos informan muy poco acerca de la suerte que tenían los recursos obtenidos por la Orden del Hospital de sus posesiones en la Corona de Castilla durante los siglos XII y XIII.
Carlos Barquero Goñi
doaj   +1 more source