Results 91 to 100 of about 155,664 (257)

Pathogen‐Centric Activation of an Azoreductase‐Responsive Antibody‐Antibiotic Conjugate for the Targeted Eradication of MRSA

open access: yesAdvanced Science, EarlyView.
A pathogen‐centric antibody‐antibiotic conjugate (AZO‐AAC) releases antibiotics via bacterial azoreductase, independent of host‐lysosomal function. This mechanism achieves nanomolar eradication of both planktonic and intracellular methicillin‐resistant Staphylococcus aureus (MRSA).
Qi Cheng   +13 more
wiley   +1 more source

Methodological Foundations of Military Psychology and Psychological Security [PDF]

open access: yesPsychology in Russia: State of Art, 2011
The article is devoted to the history of development of military psychology from psychological and philosophical positions. The transition stage in development of military psychology from classical to postclassical type of rationality is focused ...
Sergey V. Leonov   +2 more
doaj  

Sulfated Cyclocarya Paliurus Polysaccharide Sorchestrates the Gut Microbiome to Mobilize a Host‐Derived 12‐HEPE Against Ulcerative Colitis

open access: yesAdvanced Science, EarlyView.
A sulfated polysaccharide (SCP) from Cyclocarya paliurus alleviates ulcerative colitis by reshaping the gut microbiome. This remodeled microbiota orchestrates the upregulation of the host‐derived lipid 12‐HEPE, which directly inhibits the TLR4/NF‐κB pathway to suppress inflammation.
Xianxiang Chen   +11 more
wiley   +1 more source

Tracing the evolution of ancient Chinese military science through classical texts

open access: yesHeritage Science
The diachronic evolution of ancient Chinese military science is replete with profound philosophy and rich practical experience. This paper aims to delve into the diachronic evolution of the content of ancient Chinese military texts from the perspective ...
Mengcheng Wu, Dongbo Wang
doaj   +1 more source

THE IMPACT OF THE DEVELOPMENT OF MARITIME AUTONOMOUS SYSTEMS ON THE ETHICS OF NAVAL CONFLICTS [PDF]

open access: yesAnnals: Series on Military Sciences, 2018
Robotic systems are believed to be the elements of conceptual inflexion in the conduct of future military conflicts. The progress made by the military industry in the field of robotics science and engineering, coupled with the practical results obtained
Daniel-Cornel TĂNĂSESCU
doaj  

BCMA‐Engineered Dendritic Cell‐Derived Exosomes as Bi‐Functional Therapeutics Orchestrating Cytokine Sequestration and Immune Activation for Multiple Myeloma

open access: yesAdvanced Science, EarlyView.
A dual‐function cell‐free therapeutic based on DC2.4 cell‐derived exosomes engineered to display BCMA. (Left) Soluble Ligand Sequestration (Decoy Function): DB Exo act as molecular decoys that predominantly sequester soluble APRIL with partial BAFF attenuation, effectively disrupting the NF‐κB survival signaling axis and suppressing myeloma cell ...
Yuqing Zeng   +5 more
wiley   +1 more source

PROBLEMS PERTAINING TO DIVERSIFICATION OF CIVIL EQUIPMENT IN EQUIPMENT OF MILITARY PURPOSE

open access: yesНаука и техника, 2009
Study of directions concerning development of military equipment, its modernization with the purpose to improve its military efficiency is an actual problem for the Armed Forces, military science, designers and researchers.The paper analyzes and ...
A. I. Kotlabay   +4 more
doaj  

Supramolecular Assembly of Stepped‐Persistent ROS Nanogenerator for Sustained Tumor Immunotherapy

open access: yesAdvanced Science, EarlyView.
ROS catalytic systems often fail to achieve both effective tumor elimination and persistent immune activation due to their monotonous ROS production profiles. A stepped‐persistent ROS nanogenerator was developed by supramolecularly assembling multiple ROS generation modules within a nanofiber structure to simultaneously extend ROS generation duration ...
Zhenqiang Wang   +10 more
wiley   +1 more source

Senescent Cell Derived Artificial Vesicle‐Based Senolytic Sonovaccine Platform with Augmented Lymph Node Delivery and Antigen Cross‐Presentation Efficacy

open access: yesAdvanced Science, EarlyView.
A senolytic sonovaccine platform (SenoVac) is developed, in which senescent cell‐derived vesicles serve as broad senescent cell antigen reservior. The “2‐step” click chemistry strategy for effective lymph node delivery, and ultrasound‐triggered endosomal escape to boost cross‐presentation, ensures efficient senescent cell clearance and disease ...
Liang Zhang   +10 more
wiley   +1 more source

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