Results 151 to 160 of about 1,156,956 (356)

Henry Cabot Lodge, Alexander Hamilton and the Political Thought of the Gilded Age [PDF]

open access: yes, 2018
We are currently witnessing a renewal of broad public interest in the life and career of Alexander Hamilton – justly famed as an American founder. This volume examines the possible present-day significance of the man, noting that this is not the first ...
Callaway, H. G.
core  

EBBP‐Mediated Integrated Stress Response Attenuates Anthracycline‐Induced Cardiotoxicity by Inhibiting the Ferroptosis of Cardiomyocytes

open access: yesAdvanced Science, EarlyView.
EBBP expression is significantly upregulated in DOX‐treated cardiomyocytes. Mechanistically, EBBP interacts with GRP78 to mediate K63‐linked ubiquitination, thereby attenuating the inhibitory GRP78‐PERK interaction and triggering activation of the PERK‐mediated integrated stress response (ISR).
Zilong Chen   +9 more
wiley   +1 more source

High‐Performance Rechargeable Lithium‐Chlorine Batteries with ALD Conformal Starburst Porous Graphene Positive Electrodes

open access: yesAdvanced Science, EarlyView.
An Al2O3‐skinned starburst porous graphene with conformal metasurfaces is crafted from a hierarchical porous graphene with high surface pore curvature by PTFE microemulsion skin effect, leveraging subsequent atomic layer deposition of Al2O3 groups. The scalable heterostructured cathode features superhydrophilicity, effective adsorption, fast kinetics ...
Zhuo Yang   +10 more
wiley   +1 more source

Cellular Adaptation to Mechanical Stress Emerges via Cell Shrinkage Triggered by Nonlinear Calcium Elevation

open access: yesAdvanced Science, EarlyView.
Here, a decision‐making mechanism underlying mechanical adaptation is demonstrated. This study demonstrates that cellular adaptation to mechanical stress can be induced by applying low‐amplitude stretch to cells. When the stretch reaches a critical amplitude threshold, it triggers Ca2⁺‐dependent positive feedback, which induces cholesterol efflux and ...
Zhengyan Wang   +21 more
wiley   +1 more source

HPD is an RNA‐Binding Protein Sustaining Ovarian Cancer Cell Glycolysis, Tumor Growth, and Drug Resistance

open access: yesAdvanced Science, EarlyView.
HPD is identified as an RNA‐binding protein that promotes mRNA translation by binding to RRACH motifs via its double‐stranded RNA‐binding domains. This RNA‐binding activity critically sustains glycolysis in ovarian cancer cells. Disrupting HPD's RNA‐binding function effectively suppresses tumor growth and enhances therapeutic sensitivity, highlighting ...
Fei Xie   +21 more
wiley   +1 more source

Analysis and Survey the Position of Science and Technology in National Power

open access: yesتحقيقات جغرافيايی, 2018
Introduction and Background The national power of each country is rooted in a number of sources,which together form and interconnect the power of a country.
Seyed Javad Mousavi Zare   +2 more
doaj  

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