Results 131 to 140 of about 3,960 (254)

Addressing sexual violence as a weapon of war: A critical call for action in eastern Democratic Republic of Congo. [PDF]

Int J Gynaecol Obstet
Akilimali A, Balagizi F, Bhattacharjee P, Mugenyi N, Langat AK, Karegeya A, Mufungizi I, Narayan G, Kakusu D, Zihindula F, Isiko I, Banga S, Baraka L, Mukwege D, Nyakio O.   +14 more
europepmc   +1 more source

Inhibition of IGFBP4 in Granulosa Cells Improves Reproductive Performance and Maintains Fertility With Age via YAP Signaling

Advanced Science, EarlyView.
IGFBP4 is upregulated in granulosa cells of aged ovaries across monkeys, mice, and humans. It inhibits YAP signaling, thereby suppressing cell proliferation and contributing to follicular dysfunction. Deletion of Igfbp4 in granulosa cells enhances ovulatory output, improves hormone profiles, and reproductive performance in aged female mice, suggesting ...
Qianhui Hu, Ajun Geng, Ziyuan Li, Fanghao Guo, Jingqiang Wang, Xinyi Chen, Meiling Zhang, Yi Arial Zeng, Wen Li   +8 more
wiley   +1 more source

Phosphorylation‐Facilitated CKB Lactylation At K11 By GCN5 Enhances Creatine Kinase Activity and Mitigates Neuronal Damage After Cerebral Ischemia‐Reperfusion

Advanced Science, EarlyView.
This study uncovers hierarchical coordination between K11 lactylation and S199 phosphorylation of CKB in cerebral ischemia‐reperfusion injury. Such dual modifications potentiate CKB enzymatic function, remodel energy metabolism, alleviate oxidative stress and neuronal damage, and represent a viable therapeutic target for stroke treatment.
Chao Duan, Ruolin Zhang, Shihui Ding, Ying Feng, Tao Shen, Ziwei Wang, Wendai Bao, Ke Shui, Jun Qin, Jun Chen, Min Zhang, Zijing Ren, Dongmei Zhao, Xingrong Guo, Zhibing Ai, Xin Yang, Peiyang Zhou, Zhiqiang Dong   +17 more
wiley   +1 more source

Genomic Characterization of Leishmania tropica in Cutaneous Leishmaniasis, Somali Region, Ethiopia, 2023. [PDF]

Emerg Infect Dis
Abera A, Monsieurs P, Pareyn M, Beyene D, Tasew G, Aroni-Soto A, Belachew M, Geleta D, Adnew B, Gidey B, Tadesse H, Gebreegziabxier A, Abubeker R, Ali A, Tafess K, de Wit TFR, van Griensven J, Dujardin JC, Wolday D, Domagalska MA.   +19 more
europepmc   +1 more source

A Perspective on Interactive Theorem Provers in Physics

Advanced Science, EarlyView.
Into an interactive theorem provers (ITPs), one can write mathematical definitions, theorems and proofs, and the correctness of those results is automatically checked. This perspective goes over the best usage of ITPs within physics and motivates the open‐source community run project PhysLean, the aim of which is to be a library for digitalized physics
Joseph Tooby‐Smith
wiley   +1 more source

Conflict and its global health consequences: a decolonial call to action. [PDF]

BMJ Nutr Prev Health
Gamlin J, Ahmad A.
europepmc   +1 more source

Commissar of militia

Novye Issledovaniâ Tuvy, 2016
Article tells about the fate of a commissar of militia, one of the heads of the law-enforcement agencies of the People’s Republic of Tuva, Tuvan Autonomous Region Mongush Bayan-oolovich Artas. It is based on written memoirs of M.Artas, archival resources and author’s personal memories to reconstruct character’s biography and give his testimonial as ...
openaire   +1 more source

HNRNPU K181 Lactylation Drives Cervical Cancer Growth by Upregulating PHGDH and Reprogramming Serine Metabolism

Advanced Science, EarlyView.
Lactate in cervical cancer induces HNRNPU K181 lactylation, opposed by NAA50‐mediated acetylation and suppressed by Pazopanib. This lactylation enhances HNRNPU binding to PHGDH pre‐mRNA exon 1, maintaining exon 1‐containing transcripts and mRNA stability, thereby activating serine metabolism.
Chang Zhang, Qingfei Meng, Hui Jiao, Huixin Liu, Xiangchao Wang, Honglan Zhou, Yishu Wang   +6 more
wiley   +1 more source

Approval of extreme right-wing organizations and social movements and support for political violence in the United States: findings from a nationally representative survey. [PDF]

Inj Epidemiol
Wintemute GJ, Velasquez B, Li Y, Tomsich EA, Reeping PM, Tancredi D, Robinson SL.   +6 more
europepmc   +1 more source

MASH Background Confers Enhanced Disease Susceptibility and Acetaminophen Toxicity in iPSC‐Derived Liver Organoids

Advanced Science, EarlyView.
This work establishes a novel method for generating multicellular liver organoids from control and MASH donor iPSCs. The model recapitulates several disease‐specific characteristics, with MASH donor‐derived organoids showing higher susceptibility. Lipidomic profiling of MASH organoids closely resembles MASH liver biopsies.
Ekta Minocha, Ashwani Kumar Gupta, Nate Schmidt, Richard M. Green, John G. Purdy, Jason A. Wertheim   +5 more
wiley   +1 more source