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Soft‐Drug‐Inspired MnSTF Nano‐Adjuvant for Safe and Synergistic cGAS–STING Activation in Tumor Immunotherapy

open access: yesAdvanced Science, EarlyView.
This study introduces MnSTF, a soft‐drug‐inspired nanoadjuvant that overcomes the systemic toxicity of STING agonists. Through Mn2+ coordination with an ENPP1 inhibitor, it enables safe cGAS‐STING activation, remodels the tumor immune microenvironment, and synergizes with radiotherapy or vaccines to elicit robust antitumor immunity.
Guangfei Sun   +8 more
wiley   +1 more source
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Militia

2022
Abstract Article IX addresses the militia, which existed in Ohio before statehood. The Northwest Ordinance provided for the appointment of the governor as the commander-in-chief of the militia with the power to appoint all officers below the rank of general.
Steven H. Steinglass, Gino J. Scarselli
openaire   +1 more source

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