Results 171 to 180 of about 1,198,612 (297)

PRDM16 Reduces Cellular Senescence by Upregulating GSTM1

open access: yesAdvanced Science, EarlyView.
Cellular senescence drives aging and aging‐related organ disorders, yet PRDM16's role remains unexplored. This work uncovers that PRDM16 decreases significantly in aged organs, while its loss accelerates cellular senescence and aging‐related organ injury.
Qian Yuan   +7 more
wiley   +1 more source

The Pathogenic Roles of Local Vitamin D Metabolism Defect in Valve Inflammation and Calcification

open access: yesAdvanced Science, EarlyView.
This study identifies the valvular interstitial cell populations responsible for valvular calcification induced by hyperphosphatemia and likely aging, uncovers local vitamin D metabolism defect‐induced inflammation as a critical pathogenic factor of calcific aortic valve disease, and highlights active vitamin D and ERK inhibitor as potential preventive
Ruichen Yang   +10 more
wiley   +1 more source

Human Milk

open access: yes, 2006
David K. Rassin   +2 more
openaire   +2 more sources

A Peripheral Mechanism of Depression: Disturbed Intestinal Epithelial Per2 Gene Expression Causes Depressive Behaviors in Mice with Circadian Rhythm Disruption via Gut Barrier Damage and Microbiota Dysbiosis

open access: yesAdvanced Science, EarlyView.
Circardian rhythm disorder (CRD) causes abnormal expression of intestinal Period 2 (Per2) gene, which compromising intestinal barrier integrity and altering the gut microenvironment. Microbiota dysbiosis and aberrant metabolites production drive central inflammation, impair neurogenesis, and promote functional deficits, ultimately facilitating the ...
Huiliang Zhang   +16 more
wiley   +1 more source

Human Milk

open access: yes, 2011
Christopher B. Wilson, Pearay L. Ogra
openaire   +2 more sources

A Prion‐Like Domain in EBV EBNA1 Promotes Phase Separation and Enables SRRM1 Splicing

open access: yesAdvanced Science, EarlyView.
This study discoveries that EBV EBNA1 behaves as a prion‐like protein, verified using cell‐based assays and the Saccharomyces cerevisiae Sup35p prion identification system. The prion‐like domain of EBNA1 drives liquid–liquid phase separation. EBNA1 interacts with the splicing factor SRSF1 to regulate the expression of the SRRM1 splicing isoforms ...
Xiaoyue Zhang   +17 more
wiley   +1 more source

Analysis of NEC cases registered in the human milk bank database. [PDF]

open access: yesFront Pediatr
Mizuno K   +7 more
europepmc   +1 more source

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