Results 281 to 290 of about 9,713,792 (350)

Reduction in bacterial culture positivity rates at a human milk bank facility of a tertiary care hospital: a quality improvement initiative. [PDF]

BMJ Open Qual
Vadapalli S, Valvi C, Dawre RM, Bhagat V, Chivale S, Pawar S, Kinikar AA.   +6 more
europepmc   +1 more source

Reprogramming the Tumor Immune Microenvironment with ICAM‐1‐Targeted Antibody‒Drug Conjugates and B7‐H3‐CD3 Bispecific Antibodies

Advanced Science, EarlyView.
Reprogramming the tumor immune microenvironment is crucial for transforming immune “cold” tumors into “hot” inflammatory tumors. The investigation reveals that the combination of ICAM‐1‐Dxd with B7‐H3‐CD3 bispecific antibodies not only demonstrates significant inhibitory effects on tumor growth and metastasis but also plays a vital role in ...
Shoubing Zhou, Mengyu Hong, Dan Zhao, Wenyu Li, Xiaolong Yuan, Yinghong Wang, Hualong Li, Yang Yang, Tengchuan Jin, Jing Pan   +9 more
wiley   +1 more source

Associations Between Polymorphisms of the CSN1S1, CSN1S2, CSN2 and CSN3 Genes and Milk Composition Traits in Holstein Cattle. [PDF]

Vet Med Sci
Demirel AF, Çak B.
europepmc   +1 more source

Development of MDM2‐Targeting PROTAC for Advancing Bone Regeneration

Advanced Science, EarlyView.
This work presents a creative pipeline for developing MDM2‐targeting PROTACs (MDM2‐PROTACs) for application in bone regeneration. The developed PROTACs (CL144 and CL174) are validated for their degradation efficiency and osteogenic effects in human BMSCs.
Sol Jeong, Jae‐Kook Cha, Wasim Ahmed, Jaewan Kim, Minsup Kim, Kyung Tae Hong, Wonji Choi, Sunjoo Choi, Tae Hyeon Yoo, Hyun‑Ju An, Seung Chan An, Jaemin Lee, Jimin Choi, Sun‐Young Kim, Jun‐Seok Lee, Soonchul Lee, Junwon Choi, Jin Man Kim   +17 more
wiley   +1 more source

New insights into the cultivability of human milk bacteria from ingestion to digestion and implications for their Immunomodulatory properties. [PDF]

Sci Rep
Le Bras C, Mouchard A, Rault L, Cochet MF, Ménard O, Jacquet N, Chuat V, Valence F, Le Loir Y, Bellanger A, Deglaire A, Le Huërou-Luron I, Even S.   +12 more
europepmc   +1 more source

Targeted Delivery of α‐ketoglutarate to Macrophages in Bone: A Novel Therapeutic Strategy for Improving Fracture Healing in Type 2 Diabetes

Advanced Science, EarlyView.
The study reveals that glutaminolysis in macrophages is inhibited under type 2 diabetes mellitus (T2DM) conditions, which impedes fracture healing by reducing bone morphogenetic protein 2 (BMP2) production through increased cytosine methylation on the promoter.
Jing Wang, Jiahao Cao, Siqi Zhang, Hongli Chen, Xuebing Yu, Xinli Wang, Tianji Wang, Wei Cao, Wengang Dong, Xinsen Lin, Jia Li, Wei Lei, Yafei Feng   +12 more
wiley   +1 more source

Assessment of hazardous trace metals and associated health risk as affected by feed intake in buffalo milk. [PDF]

Sci Rep
Shahzad S, Ashraf K, Ehsan N, Sultan K, Abbasi A, Tabassum S, Muzamil A, Rebouh NY, Zaman QU.   +8 more
europepmc   +1 more source

LIMA1 O‐GlcNAcylation Promotes Hepatic Lipid Deposition through Inducing β‐catenin‐Regulated FASn Expression in Metabolic Dysfunction‐Associated Steatotic Liver Disease

Advanced Science, EarlyView.
Early diagnosis and treatment of metabolic dysfunction‐associated steatotic liver disease (MASLD) remains a significant challenge. This study indicates that serum sEV LIMA1 may serve as a noninvasive biomarker for MASH. The HCF1/OGT complex induces O‐GlcNAcylation of the LIMA1 protein, and subsequently promotes lipid accumulation in hepatocytes by ...
Fuji Yang, Yifei Chen, Guojun Zheng, Kefeng Gu, Lin Fan, Tingfen Li, Ling Zhu, Yongmin Yan   +7 more
wiley   +1 more source

Impact of Maternal Exposure to SARS-CoV-2 on Immunological Components of Breast Milk. [PDF]

Int J Mol Sci
Graciliano NG, Goulart MOF, de Oliveira ACM.   +2 more
europepmc   +1 more source