Results 121 to 130 of about 1,788,588 (332)

The TET3/GATA6 Axis Drives Lipid Metabolism and Therapeutic Vulnerabilities in Pancreatic Ductal Adenocarcinoma

open access: yesAdvanced Science, EarlyView.
The DNA demethylase TET3 drives lipid metabolic reprogramming in pancreatic ductal adenocarcinoma via a non‐catalytic mechanism. TET3 recruits histone deacetylases to repress GATA6, sustaining lipogenic enzyme expression and ferroptosis resistance.
Shuai Liu   +8 more
wiley   +1 more source

Bacillus cereus strains from donor human milk and hospital environment: uncovering a putative common origin using comparative analysis of toxin and infra-red spectroscopy profiles

open access: yesAIMS Microbiology, 2023
Bacillus cereus is reported as a common cause of toxin-induced food poisoning and of contamination in pasteurized human milk donations. As various toxins can be produced by B.
Gaëtan Outurquin   +6 more
doaj  

Colorectal Cancer Cells–Derived Exosomal PIK3CA Mutation DNA Promotes Tumor Metastasis by Activating Fibroblast and Affecting Tumor Metastatic Microenvironment

open access: yesAdvanced Science, EarlyView.
PIK3CAH1047R DNA in colorectal cancer (CRC) cell‐derived exosomes can be delivered into recipient fibroblasts, where it is transcribed and translated, leading to the activation of fibroblasts into cancer‐associated fibroblasts, which secrete elevated levels of IL6. The simultaneous detection and targeting of PIK3CAH1047R mutation and IL6 may serve as a
Rui Wang   +6 more
wiley   +1 more source

Healthy Aging Update, October 1, 2007, Vol. 2, no. 6 [PDF]

open access: yes, 2007
This bimonthly electronic newsletter will provide information and resources on nutrition and health promotion and disease prevention. The Healthy Aging Update is produced for informal and educational purposes only.

core  

The GRK2/AP‐1 Signaling Axis Mediates Vascular Endothelial Dysfunction and Atherosclerosis Induced by Oscillatory Low Shear Stress

open access: yesAdvanced Science, EarlyView.
This study highlights GRK2 is a central mediator in OSS‐induced endothelial dysfunction. OSS activates GPCRs in endothelial cells, leading to GRK2 phosphorylation and the activation of AP‐1. AP‐1 induces inflammation, while also promoting NR4A1 expression and anchoring LKB1 in the nucleus, which suppresses AMPK activity. This cascade causes endothelial
Li‐Da Wu   +18 more
wiley   +1 more source

Amamentar e doar leite: percepções das mulheres doadoras de um Banco de Leite Humano

open access: yesRevista Educação em Saúde, 2018
Objective: To describe and analyze the factors that facilitate the donation of breast milk as well as the difficulties in the perspective of the women donor.
Mateus Guilhardi Rosa e Silva   +5 more
doaj   +1 more source

Regenerative Hair Pigmentation via Skin Organoids: Adaptive Patterning Mediated by Collagen VI and Semaphorin 3C

open access: yesAdvanced Science, EarlyView.
The release of COL6A3 by fibroblasts is sensed by the CD44 receptor on melanocytes, activating glutathione (GSH) metabolism and increasing melanocyte survival during skin organoid culture. SEMA3C released by bulge cells binds to the NRP1 receptor on melanocytes, regulating microtubule stability and promoting melanocyte recruitment and function during ...
Tingting Li   +17 more
wiley   +1 more source

Creating Shared Value in India: How Indian Corporations Are Contributing to Inclusive Growth While Strengthening Their Competitive Advantage [PDF]

open access: yes, 2011
Leading companies are finding new ways to accelerate growth and increase competitive advantage through innovative business models that meet societal needs at scale.
Lalitha Vaidyanathan   +3 more
core  

Maternal insecurity in breastfeeding women served at a human milk bank [PDF]

open access: diamond, 2021
Waleska Lima Alves Simas   +5 more
openalex   +1 more source

Fast pH‐Driven Solubilization Method of Realgar (As4S4) to Reduce the Toxicity of Arsenic [As(III)] for Medicinal Purposes

open access: yesAdvanced Science, EarlyView.
Arsenic trioxide transformed acute promyelocytic leukemia therapy and shows promise against HIV. A new method to solubilize the mineral realgar produces different arsenic species depleting the main arsenic target, nuclear PML protein, and retaining effects on leukemic and HIV reservoir cells, while minimizing off‐target damage.
Bojana Lucic   +20 more
wiley   +1 more source

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