Brain Pathology, EarlyView.We generated digital pathologic algorithms (AI‐based modules that can be freely shared) to: optimize the sampling (ROI) for diagnosis of ADNC‐related tau pathology; compare/transition between Aperio and HALO platforms; and rationalize severe Braak NFT staging, so that all Braak‐VI cases had dementia, and all Braak‐V cases had MCI or dementia.
Ryan K. Shahidehpour +10 more
wiley +1 more source
'Your baby can take my milk… but my baby won't take yours'; determinants of willingness to donate and utilize human breast milk among pregnant women at a health facility in limited resource settings. [PDF]
Int Breastfeed JKamau JW +3 more
europepmc +1 more source
British Journal of Pharmacology, EarlyView.Background and Purpose Notoginsenoside‐Fa (Noto‐Fa) is an emerging active compound derived from notoginseng with promise in treating cardiovascular diseases. The development of cardiovascular diseases is intricately linked to the damage of vascular endothelium and it is widely acknowledged that numerous chronic inflammation pathways, especially the ...
Xiao‐Ying Yu +9 more
wiley +1 more source
Evaluating the Effect of Random Multi-Donor Pooling on the Nutritional Variability in Donor Human Milk Using Computer Modeling. [PDF]
Matern Child NutrSmith RM +9 more
europepmc +1 more source
Cancer Science, EarlyView.Schematic illustration showing how CRC‐associated ADSC‐derived CCL8 promotes colorectal cancer cell migration through ERK/HIF‐1α signaling in a 3D coculture platform. ABSTRACT This study aimed to recapitulate adipose‐tumor interactions within the colorectal cancer (CRC) tumor microenvironment (TME) and to elucidate the role of adipose‐derived stem ...
Jeong‐Eun Yun +7 more
wiley +1 more source
Improving the composition of donor milk using machine learning and optimisation techniques. [PDF]
PLoS OneMuts J +7 more
europepmc +1 more source
Feiwei Heji Enhances Antitumor Immunity by MLL4‐Dependent Regulation of Pyroptosis in Lung Cancer
Cancer Science, EarlyView.Feiwei Heji suppresses lung tumor growth by downregulating MLL4 and activating caspase‐1/GSDMD‐associated pyroptosis. This pyroptosis‐related inflammatory response enhances CD8+ T‐cell‐mediated antitumor immunity, revealing an MLL4‐pyroptosis‐immune axis underlying the therapeutic activity of Feiwei Heji.
Nan Cheng +6 more
wiley +1 more source
Exploring human milk donation: A cross-sectional study. [PDF]
Public Health Pract (Oxf)Present E, Driessen E, Kuipers Y.
europepmc +1 more source
Targeting the NR3C1‐ACSL4 Axis Triggers Ferroptosis to Overcome Radioresistance in Prostate Cancer
Cancer Science, EarlyView.The glucocorticoid receptor NR3C1 drives prostate cancer radioresistance by upregulating ACSL4. High ACSL4 levels create a lipid metabolic vulnerability. The clinical agent DHA synergizes with ACSL4 to induce lipid peroxidation and ferroptosis, effectively overcoming radioresistance.
Jing Yang +7 more
wiley +1 more source
Donor Experience and Satisfaction: A Cross-Sectional Survey of Australian Milk Donors. [PDF]
Matern Child NutrNewman C +5 more
europepmc +1 more source