Advanced Science, EarlyView.This study identifies the HDAC6/GATA4/HtrA1 axis as a critical driver of cellular senescence in the inner ear. GATA4 nuclear translocation, facilitated by HDAC6 downregulation, transcriptionally activates HtrA1, promoting hair cell senescence, SASP, and audio‐vestibular dysfunction in models of Ménière's disease and age‐related audio‐vestibular ...
Na Zhang +16 more
wiley +1 more source
Endocytic Control of Cell‐Autonomous and Non‐Cell‐Autonomous Functions of p53
Advanced Science, EarlyView.NUMB Ex3‐containing isoforms localize to the plasma membrane, where they recruit p53 through SNX9 and direct it to multivesicular bodies and exosomes. Exported p53 is taken up by neighboring cells and activates nuclear programs, revealing an intercellular, exosome‐based pathway that might help establish a tumor‐suppressive microenvironment.
Roberta Cacciatore +20 more
wiley +1 more source
Seasonality in the Irish dairy processing industry [PDF]
The dairy landscape in the Republic of Ireland is characterized by pastoral spring-calving systems and a bell-shaped milk production curve. This seasonality at producer level initiates various implications at processor level, such as poor utilization of ...
Heinschink, Karin E. +2 more
core +1 more source
Unraveling the Molecular Mechanisms Underlying Spontaneous Multipolar Mitosis Through CIN‐seq
Advanced Science, EarlyView.Multipolar mitosis, a hallmark of chromosomal instability (CIN), drives tumor heterogeneity but is challenging to study in live cells. Using CIN‐seq, a single‐cell multiomics method, we profiled rare CIN events and identified mechanisms associated with viable multipolar mitosis, including PTEN attenuation, Rho GTPase‐driven cytokinesis failure, and ...
Pin‐Rui Su +10 more
wiley +1 more source
Endogenous adjusted Output Quotas - The Abolishment of the Raw Milk Quota in the European Union [PDF]
This paper discusses an approach to implement output quotas in the GTAP model which permits an endogenous adjustment of both the supplied quantity and the quota rent.
Lips, Markus, Rieder, Peter
core +1 more source
A Central Somatic Transmission Mediates Proprioceptive Facilitation of Muscle Pain
Advanced Science, EarlyView.Zhang et al. uncover a novel central mechanism for persistent muscle pain, in which TRPA1 sensitization in MeV proprioceptive neurons enhances somatic secretion. This, in turn, disinhibits descending pain control from neighboring noradrenergic locus coeruleus neurons via local GABAergic circuits, thereby promoting inflammatory muscle pain.
Xiaoyu Zhang +15 more
wiley +1 more source
A FRAMEWORK FOR EVALUATING THE ECONOMIC IMPACT OF CLASSIFIED PRICING OF MILK [PDF]
The objective of this paper is to analyze the effects of increasing, decreasing, or having no-minimum Class I differentials on regional fluid milk consumption, milk production, prices received by farmers, and the U.S.
Buxton, Boyd M.
core +1 more source
Paternal Circadian Disruption Impairs Offspring Cognition via Sperm microRNAs
Advanced Science, EarlyView.Paternal circadian disruption remodels the sperm small RNA payload, elevating miR‐92a‐3p/miR‐25‐3p levels and perturbing early embryonic gene regulatory programs. Microinjection experiments and single‐embryo transcriptomics reveal sex‐specific developmental vulnerabilities, ultimately impairing offspring hippocampal synaptic plasticity and cognition ...
Kexin Zou +22 more
wiley +1 more source
Improved transition period management increases milk production of Holstein crossbred cows on smallholder farms in Ethiopia. [PDF]
Trop Anim Health ProdNdambi OA, Fodor I, Aranguiz AA.
europepmc +1 more source
Estimates of the increase in milk production due to the introduction of maize silage to a dairy farm in KwaZulu-Natal: A time series approach [PDF]
A method involving time series modelling is provided for evaluating the effects of an abrupt intervention, such as the adoption of a new technology, when no control is available for comparative evaluation. The new technology was the introduction of maize
Mkhabela, Thulasizwe S.
core +1 more source