Results 321 to 330 of about 6,244,449 (384)

On the Distribution of Thermophilic Bacteria in Milk and Dairy Products

, 1964
Michio HAMAMOTO, Tetsuji Hirota, Toshiro KANAUCHI, Kazuo Mino   +3 more
openalex   +2 more sources

Nrf2 Drives Epigenetic Reprogramming and Acts as the Master Regulator of KLF4 Expression and Activity in Arsenic‐Induced Transformation

Advanced Science, EarlyView.
Nrf2 isn't just a protector—it's a driver of cancer stemness. The study uncovers how arsenic‐activated Nrf2 directly upregulates KLF4, a key pluripotency factor, fueling oncogenic reprogramming. Through enhancer activation and self‐reinforcing loop, Nrf2 and KLF4 co‐opt gene networks linked to epithelial‐to‐mesenchymal transition and tumor growth ...
Ziwei Wang, Zhuoyue Bi, Jessica Bamrah, Yiran Qiu, Wenxuan Zhang, Bandar Saeed Almutairy, Haoyan Ji, John D. Haley, Chitra Thakur, Fei Chen   +9 more
wiley   +1 more source

Nanoparticle‐Mediated CXCL12–CXCR4 Inhibition Reprograms Macrophages and Suppresses Gastric Carcinoma

Advanced Science, EarlyView.
Molecular mechanism study of self‐assembled M2pep‐Cs NPs/Plerixafor nanoparticles in targeting MΦ reprogramming by regulating the CXCL12–CXCR4 signaling pathway to enhance immune recognition and clearance of GC (Created by BioRender). Abstract Gastric carcinoma (GC) remains a major global health challenge, requiring novel therapeutic approaches.
Qianqian Cao, Xiaolei Cheng, Rongbin Lv, Dianshui Sun, Jihua Wang, Runjia Fu, Rumei Gong, Yueying Xiao, Qin Liu, Xiaomei Li   +9 more
wiley   +1 more source

Novel Antimicrobial Protein Fibroblast Growth Factor 8 Accelerates Skin Wound Healing via Directly Inhibiting Bacteria and Activating Glycolysis

Advanced Science, EarlyView.
Wound infections induce gcFGF8a expression, which subsequently executes direct antimicrobial activity to suppress local infection while simultaneously activating the FGFR4‐mediated ERK/AKT‐mTOR signaling cascade, thereby upregulating HIF1α and enhancing glycolysis. These coordinated actions synergistically promote tissue repair by eliminating pathogens
Ya‐Zhen Hu, Ting Wang, Chang‐Song Wu, Jie Wang, Xue‐Qing Han, Yong‐An Zhang, Xu‐Jie Zhang   +6 more
wiley   +1 more source

Adulterants in Milk and Milk Products

Journal of Dairy Science, 1960
openaire   +2 more sources

ACSS2‐Mediated Histone H4 Lysine 12 Crotonylation (H4K12cr) Alleviates Colitis via Enhancing Transcription of CLDN7

Advanced Science, EarlyView.
Histone lysine crotonylation (Kcr) is a highly conserved posttranslational modification implicated with crucial biological processes. This study reveals that ACSS2‐mediated H4K12cr upregulated CLDN7 transcription to strengthen intestinal epithelial barrier.
Ming Yuan, Shaopeng Chen, Zhensen Lin, Runfeng Yu, Kang Chao, Shubiao Ye, Qing Li, Haoxian Ke, Chi Zhang, Junfeng Huang, Guanzhan Liang, Tuo Hu, Xiang Gao, Ping Lan, Xianrui Wu   +14 more
wiley   +1 more source

Paracrine Orchestration of Tumor Microenvironment Remodeling Induced by GLO1 Potentiates Lymph Node Metastasis in Breast Cancer

Advanced Science, EarlyView.
Single‐cell RNA sequencing of lymph node (LN) samples is performed, and a comprehensive landscape of the entire ecosystem is generated. Paracrine orchestration of TME remodeling induced by GLO1 potentiates LN metastasis in breast cancer. This study offers novel perspectives on the microenvironment remodeling of breast cancer LN metastases, suggesting ...
Jindong Xie, Wenjian Liu, Xinpei Deng, Huan Wang, Xueqi Ou, Xin An, Min‐Yi Situ, Anli Yang, Chuan Peng, Rongfang He, Yi Xie, Hailin Tang, Yuman Chen, Jie‐Ying Liang, Ruonan Shao, Weikai Xiao, Shaoquan Zheng   +16 more
wiley   +1 more source

The Evolutionary Trajectory and Prognostic Value of GITR+ Tregs Reprogramed by Tumor‐Intrinsic PD‐1/c‐MET Signaling in Pancreatic Cancer

Advanced Science, EarlyView.
In pancreatic ductal adenocarcinoma (PDAC), tumor‐intrinsic PD‐1 signaling activates the MET pathway, leading to the establishment of an immunosuppressive tumor microenvironment (TME). This MET‐driven signaling cascade promotes the selective accumulation of GITR+ regulatory T cells (Tregs), a highly immunosuppressive subset.
Jiande Han, Hanlin Yin, Taochen He, Junyi He, Zhenlai Jiang, Qiangda Chen, Zhihang Xu, Yuqi Xie, Yaolin Xu, Haibo Wang, Wenquan Wang, Wenchuan Wu, Yun Jin, Wenhui Lou, Jun Yu, Ning Pu, Liang Liu   +16 more
wiley   +1 more source

Gastrula‐Premarked Posterior Enhancer Primes Posterior Tissue Development Through Cross‐Talk with TGF‐β Signaling Pathway

Advanced Science, EarlyView.
A gastrula‐premarked enhancer within the first intron of Cdx2 governs posterior embryonic development via both regulating Cdx2 expression in cis and coordinating TGF‐β signaling in trans to ensure proper posterior body development. Functional rescue in gastruloids reveals a Cdx2‐independent pathway, highlighting p‐Enh‐eRNA as key epigenetic ...
Yingying Chen, Fengxiang Tan, Qing Fang, Lin Zhang, Jiaoyang Liao, Penglei Shen, Yun Qian, Mingzhu Wen, Rui Song, Yonggao Fu, He Jax Xu, Ran Wang, Cheng Li, Zhen Shao, Jinsong Li, Naihe Jing, Xianfa Yang   +16 more
wiley   +1 more source

Sleep Deprivation Aggravates Periodontitis Through Trigeminal‐Periodontal Neuroimmune Pathway Mediated by the AChE‐ACh‐α7nAChR Axis

Advanced Science, EarlyView.
Sleep deprivation (SD) exacerbates ligature‐induced periodontitis (LIP) through the trigeminal nerve‐periodontal neuroimmune pathway mediated by the acetylcholinesterase (AChE)‐acetylcholine (ACh)‐α7 nicotinic receptor (α7nAChR) axis. While electroacupuncture (EA) alleviates the condition of LIP combined with SD by activating the α7nAChR.
Kehao Liu, Qi Huang, Mingcong Yang, Ziyu Huang, Kamoran Tuerhong, Yue Zu, Ying Xie, Xuehui Hu, Qianyu Zhang, Ping He, Nannan Huang, Rong Zhang, Yuzhou Li, Sheng Yang   +13 more
wiley   +1 more source