Results 71 to 80 of about 1,969,759 (302)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Genetic studies on various production and reproduction traits of Sahiwal and crossbred cattle (HFxJerseyxSahiwal) of an organised farm

Veterinary World, 2010
The present investigation was undertaken on data of 30 Sahiwal cattle and 30 crossbred cattle (HF × Jersey × Sahiwal) from Instructional Dairy Farm (IDF), G.B. Pant University of Agriculture & Technology, Pantnagar, Uttarakhand.
Anjan Dandapat, Dipak Banerjee, Dibyendu Chakraborty   +2 more
doaj  

Effect of pre-calving body condition score and previous lactation on BCS change, blood metabolites, oxidative stress and milk production in Holstein dairy cows

Italian Journal of Animal Science, 2017
The aim of study was to determine the effect of pre-calving body condition score (BCS) and previous milk yield on BCS change, blood metabolites, oxidative stress and milk production in Holstein cows.
Negin Jamali Emam Gheise, Ahmad Riasi, Ahmad Zare Shahneh, Pietro Celi, Seyed Mehdi Ghoreishi   +4 more
doaj   +1 more source

Impact of single nucleotide polymorphisms in leptin, leptin receptor, growth hormone receptor, and diacylglycerol acyltransferase (DGAT1) gene loci on milk production, feed, and body energy traits of UK dairy cows [PDF]

, 2008
The impact of 9 single nucleotide polymorphisms (SNP) in the leptin (LEP), leptin receptor (LEPR), growth hormone receptor (GHR), and diacylglycerol acyltransferase (DGAT1) gene loci on daily milk production, feed intake, and feed conversion, and weekly ...
Woodward, B. W., Forbes, A. B., Coffey, M. P., Banos, G., Woolliams, J. A.   +4 more
core   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Evaluation of reference lactation length in Chios dairy sheep

Animal, 2019
Definition and establishment of a fixed reference lactation length could provide useful tools for on-farm comparison of ewes and flock management as well as genetic evaluations for the breeding programme. The objectives of this study were to (i) evaluate
Z. Basdagianni, E. Sinapis, G. Banos
doaj   +1 more source

RELATIONSHIP OF UDDER AND BODY MEASUREMENTS WITH MILK IELD IN HOLSTEIN COWS REARED IN EGYPT [PDF]

Fayoum Journal of Agricultural Research and Development, 2019
The aim of the present study was to study the relationship of udder and body measurements with milk yield in Holstein cows in Egypt. Milk yield, udder and body measurements were recorded using 10 Holstein cows in first and second parity.
A. I Semaida, El-khashab, A. Mona, Rohayem, A.,   +2 more
doaj   +1 more source

Variation in Lactation Yield of Milk Constituents

Journal of Dairy Science, 1966
Abstract The lactation production of milk, milk fat, solids-not-fat (SNF), and total solids from cows of six breeds in seven Midwest states was used to investigate gross environmental effects on these traits and to consider correlated responses due to selection for a single trait.
R P, Blanchard, A E, Freeman, P W, Spike
openaire   +2 more sources

Merging and characterising phenotypic data on conventional and rare traits from dairy cattle experimental resources in three countries [PDF]

, 2012
peer-reviewedThis study set out to demonstrate the feasibility of merging data from different experimental resource dairy populations for joint genetic analyses.
Coffey, M.P., Veerkamp, Roel F., Coffey, M. P., Veerkamp, RF, Berry, D.P., Berry, D. P., Berry, DP, Wall, E; id_orcid, Wall, E., Veerkamp, R.F., Coffey, Mike P., Veerkamp, R. F., Coffey, MP, Banos, G., Banos, G; id_orcid, Berry, Donagh   +15 more
core   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source