Results 151 to 160 of about 467,653 (314)

GSH‐Responsive Nanoparticles Enhance Hepatocellular Carcinoma Immunotherapy Through Synergistic Effects of Cuproptosis and PI3K Inhibitor Combination

Advanced Science, EarlyView.
ABSTRACT Cuproptosis, an emerging form of programmed cell death, is capable of inducing mitochondrial dysfunction. Moreover, the PI3K‐AKT‐mTOR signaling pathway contributes to tumor cell progression by reprogramming mitochondrial morphology and function.
Lei Wu, Jintong Na, Xiyu Liu, Dongsheng Tang, Zhungang Yang, Zheng Cao, Xinyue He, Haihua Xiao, Liping Zhong, Yuan Liao, Yongxiang Zhao   +10 more
wiley   +1 more source

ELABELA Targets Mitochondria to Modulate Heart Development

Advanced Science, EarlyView.
The role of peptide ELABELA (ELA) in cardiomyocyte apoptosis and congenital heart disease (CHD) is unclear. ELA deficiency caused cardiomyocyte apoptosis and CHD. A novel ELA‐APJ‐AKT‐BCL2/BAX axis in regulating mitochondrial function and contributing to CHD pathogenesis was established.
Jian Wang, Qingjie Wang, Zhikang Xu, Shuang Zhou, Yue Zhou, Junjie Yang, Lingfeng Tong, Zhuo Meng, Mei Yang, Wen Zhao, Tie Yang, Hualin Wang, Jun Zhang, Rubin Tan, Lei Wang, Yuqiang Huang, Bin Zhou, Sun Chen, Bing Zhang, Jinxiang Yuan, Jianyuan Zhao, Alex F. Chen, Kun Sun   +22 more
wiley   +1 more source

Effect of protein coated with protected fat on milk production parameters [PDF]

Eurasian Journal of Veterinary Sciences
The effects ol oils and protein coated with Ca soaps or milk production parameters were investigated in this study The effect of acidulated oil + soybean meal + Ca(OH)2 (AY) and protein coated acid oil Ca soaps (PKAYl on dry mattei intake and milk yield ...
Nurettin Gülşen, Fatma inal
doaj  

Investigating the relationship between fluctuations in daily milk yield as resilience indicators and health traits in Holstein cattle

Journal of Dairy Science
: Disease-related milk losses directly affect dairy herds' profitability and the production efficiency of the dairy industry. Therefore, this study aimed to quantify phenotypic variability in milk fluctuation periods related to diseases and to explore ...
Ao Wang, Guosheng Su, Luiz F. Brito, Hailiang Zhang, Rui Shi, Dengke Liu, Gang Guo, Yachun Wang   +7 more
doaj   +1 more source

QBP1 Peptide as a Potential Anti‐Amyloidogenic Therapy for Type 2 Diabetes: An In Vitro Study

Advanced Science, EarlyView.
The anti‐amyloidogenic peptide QBP1 effectively halts human islet amyloid polypeptide (hIAPP) aggregation, preventing the formation of toxic β‐structured intermediates. Through a combination of biophysical assays, molecular dynamics, and cell‐based studies, QBP1 is shown to preserve β‐cell viability and metabolic homeostasis, positioning it as a ...
María M. Tejero‐Ojeda, Ada Bernaus Vives, Michał Wojciechowski, Dinh Quoc Huy Pham, Mateusz Chwastyk, Mario Vallejo, Anna Novials, Douglas V. Laurents, Mariano Carrión‐Vázquez   +8 more
wiley   +1 more source

The Effect of Genetic and Infrastructure Investments in Dairy and Beef Producers' Profit in Chile [PDF]

The objective of this study was to evaluate the effect of infrastructure and genetic improvement investments, promoted by a government program (Programa de Modernizacion Ganadera), in milk and meat producers' profit in Region IX.
Alegre, Miguel, Foster, William E., Melo, Oscar, Ortega, Jorge   +3 more
core   +1 more source

RNF213 Is an Interferon‐Stimulated Gene That Targets Influenza A Virus NP and Activates MDA5 to Restrict Infection

Advanced Science, EarlyView.
RNF213 is characterized as a dual‐functional antiviral effector. It directly mediates the degradation of the influenza A virus nucleoprotein (NP) while simultaneously activating the MDA5‐mediated innate immune signaling pathway. This coordinated response establishes a powerful host defense system against viral infection. ABSTRACT Influenza A virus (IAV)
Haoning Li, Yuying Zhang, Jingjing Wang, Qianqian Zhang, Hailiang Sun, Fanhua Wei   +5 more
wiley   +1 more source

Performance and feed intake of five beef suckler cow genotypes and pre-weaning growth of their progeny [PDF]

, 2008
peer-reviewedThe effect of beef suckler cow genotype on feed intake, performance, milk yield and on pre-weaning growth of their progeny was determined over four lactations.
Drennan, Michael J, McGee, Mark, Murphy, B.M., O'Mara, Frank P.   +3 more
core  

A Biomarker‐Driven Ovary–Endometrium Organ‐on‐a‐Chip Mimicking 3D Multicellular Complexity and Menstrual Cyclicity for Predicting Reproductive Toxicity

Advanced Science, EarlyView.
We present a dual‐organ, biomarker‐integrated ovaryendometrium organ‐on‐a‐chip that recapitulates 3D tissue complexity, menstrual cycle dynamics, and hormonal crosstalk. This platform enables real‐time, cell‐typespecific fluorescent readouts of reproductive toxicity using ANGPTL4 and SERPINB2 as early‐response reporters.
Soo‐Rim Kim, Eun‐kyung Min, Choon‐Mi Lee, Chan Hum Park, Byung‐Chul Oh, YunJae Jung, In‐Sun Hong   +6 more
wiley   +1 more source

Genetic evaluation of Holstein-Friesian and Jersey sires using records from pure- and cross-bred progeny in New Zealand : a thesis presented in partial fulfilment of the requirements for the degree of Master of Agricultural Science in animal science at Massey University [PDF]

, 1991
Milk Yield, Milk Fat Yield, Milk Protein Yield and Days in Milk of 72,480 dairy cows of Holstein-Friesian, Jersey and their reciprocal crossbred were analysed.
Nejati-Javaremi, Ardeshir
core