Results 91 to 100 of about 1,969,759 (302)

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Genetic relationship between weaning weight and milk yield in Nguni cattle

Animal, 2018
A study was conducted to estimate the genetic relationship between weaning weight and milk yield in Nguni cattle. Milk yield data (n=125) were collected from 116 Nguni cows from Mara Research Station located in Limpopo Province and Loskop South Farm ...
L.T. Nesengani, K.A. Nephawe, J. Sebei, D. Norris, A. Maiwashe   +4 more
doaj   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Genetic parameter estimation to milk yield and fat and protein yield deviated from 3% of concentration in milk, in dairy herds of southern Chile

Austral Journal of Veterinary Sciences, 2017
Chilean milk processing industry is providing clear signs to milk farmers regarding the significant importance of milk solids within raw milk payment schemes.
Héctor Uribe, Humberto González, Carlos Gatica   +2 more
doaj   +1 more source

Investigations on Milk Flow and Milk Yield from Teats with Milk Flow Disorders

Journal of Dairy Science, 2002
The objective of this study was to investigate peak milk flow, average milk flow, and milk yield in teats with milk flow disorders. A total of 100 hard milking teats were studied in 97 cows. Teats with milk flow disorders were examined endoscopically.
Julia, Ouerengässer, Thomas, Geishauser, Klaus, Querengässer, Rupert, Bruckmaier, Klaus, Fehlings   +4 more
openaire   +2 more sources

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Characteristics of milk production traits of Balkan goats raised under “low-input” production systems

Mljekarstvo, 2010
In order to analyse dairy production traits (milk yield in full lactation, milk fat content, daily milk yield and length of lactation) of Balkan goats raised under “low-input” production systems, data on 440 lactation records from 118 does raised on 9 ...
Vladan Bogdanović
doaj  

Estimation of the Genetic Parameters for Test-Day Milk, in Teleorman Black Head Sheep

Scientific Papers Animal Science and Biotechnologies, 2023
The objective of this study was to determine the genetic parameters represented by heritability for test-day milk yield and the genetic correlation between test-days milk yield and the breeding value for Teleorman Black Head sheep. The genetic parameters
Rodica Stefania Pelmus, Horia Grosu, Mircea Catalin Rotar, Mihail Alexandru Gras, Cristina Lazar, Florin Popa, Elena Ghita   +6 more
doaj  

Genetic evaluation of fertility using direct and correlated traits [PDF]

, 2003
Poor fertility has become a major reason for involuntary culling of dairy cows in the United Kingdom. Calving interval (CI) and body condition score (BCS) are recorded, heritable, genetically correlated with each other, and could be used to extend the ...
Coffey, M.P., G. Banos, J.A. Woolliams, S. Brotherstone, Banos, Georgios, Wall, E; id_orcid, Brotherstone, S., Wall, E., Woolliams, JA, Coffey, MP, E. Wall, Woolliams, John, Brotherstone, S, Banos, G; id_orcid, M.P. Coffey   +14 more
core   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source