Results 221 to 230 of about 467,653 (314)

Integrative metabolomics and hormonal profiling reveal biomarkers of milk yield efficiency in Sapera dairy goats under tropical conditions. [PDF]

Vet World
Islamiyati R, Azis IU, Amal I, Bahar MR, Sabil S, Santoso S, Khan FA, Nurlatifah A, Diansyah AM, Irawan F, Damayanti E.   +10 more
europepmc   +1 more source

Design of Safe and Efficient Adenine Base Editors via Protein Language Model Screening for Osteoarthritis Treatment

Advanced Science, EarlyView.
ABSTRACT Base editors enable precise genome modification and have emerged as a promising therapeutic approach for correcting diseases caused by single‐nucleotide variants. While the current efficient version of adenine base editors (ABEs), such as ABE8e, exhibits exceptional efficiency for A‐to‐G conversions, their clinical translation is hindered by ...
Jiawei Yao, Dalin Chen, Ziyi Zhang, Jingxuan Ren, Chengcheng Zhao, Shengfang Wang, Mengyu Shang, Dawei Jiang, Yinuo Li, Su'an Tang, Kai Li, Xiaohui Zhang, Xiaogang Wang   +12 more
wiley   +1 more source

Long-Term <i>Saccharomyces cerevisiae</i> Supplementation Enhances Milk Yield and Reproductive Performance in Lactating Dairy Cows on Smallholder Farms. [PDF]

Animals (Basel)
Suayroop N, Khanthusaeng V, Kraisoon A, Bunma T, Nabthonglang J, Navanukraw P, Haitook T, Cherdthong A, Navanukraw C.   +8 more
europepmc   +1 more source

A Metal‐Free Carbon Monoxide Prodrug Suppresses Metastasis of Pancreatic and Breast Cancer

Advanced Science, EarlyView.
A metal‐free carbon monoxide (CO) prodrug, CO‐116, delivers controlled systemic CO without inhalation. CO suppresses the HRG1–heme axis, reducing intracellular heme availability. Attenuation of this pathway inhibits metastatic progression in pancreatic and triple‐negative breast cancer models.
Tiantian Zhang, Xiang Chen, Xiaoxiao Yang, Muskan Gori, Rohit Kumar Varshnaya, Dongning Liu, Cheryl Zhang, Michelle Yi Qin Chen, Zhengming Chen, George Zhang, Erika Patel, Qiyue Mao, Tan A. Ince, Chalet Tan, Binghe Wang, Yi‐Chieh Nancy Du   +15 more
wiley   +1 more source

Relationship Between Age at First Calving and 305-Day Milk Yield in Hungarian Holstein-Friesian Cows: Trends and Genetic Parameters. [PDF]

Animals (Basel)
Bene SA, Kőrösi ZJ, Bognár L, Polgár JP, Szabó F.   +4 more
europepmc   +1 more source

NIPAL1 Drives a Metabolic‐Epigenetic Feedback Loop to Promote Lactate‐Mediated Immune Evasion in Esophageal Cancer

Advanced Science, EarlyView.
The study identifies a NIPAL1‐driven metabolic‐epigenetic circuit in esophageal squamous cell carcinoma that promotes glycolysis, lactate accumulation, and H3K18 histone lactylation, forming a self‐sustaining loop that suppresses CD8+ T cell immunity.
Ri‐Xin Chen, Xiao‐Dan Ma, Shui‐Dan Xu, Ao‐Tian Mo, Min‐Hua Deng, Jun‐Han Wu, Wei‐Tao Zhuang, Jin‐Ling Duan, Shu‐Huan Xie, Jin‐Long Lin, Peng Lin, Ji‐Ming Tang, Hai‐Yu Zhou, Xiao‐Song Ben, Gui‐Bin Qiao, Dan Xie   +15 more
wiley   +1 more source

Grazing versus housing in native dairy goats: Impacts on milk yield, composition, and conjugated linoleic acid enrichment under arid conditions. [PDF]

Vet World
Trejo-López MT, Hernández-Mendo O, Granados-Rivera LD, Torres-Hernández G, Maldonado-Jáquez JA, Hernández-Sánchez D.   +5 more
europepmc   +1 more source

N4‐acetylcytidine in LncRNA Gm26917 Promotes Translation in Female Germline Stem Cells by Recruiting Ribosomal Protein mRNA via EEF1A1

Advanced Science, EarlyView.
This work establishes that ac4C modification on lncRNA Gm26917 governs its spatial interactions with Rpl10 mRNA, and RBP EEF1A1 mediates the interaction between Gm26917 and Rpl10. It elucidates a novel ac4C‐Gm26917‐EEF1A1‐Rpl10 axis in FGSC maintenance both in vitro and in vivo, and provides a potential molecular target for modulating germ cell ...
Xinyue Li, Xiaopeng Hu, Ji Wu
wiley   +1 more source

Effects of Tick Infestation on Milk Yield, Blood Biochemistry, Hematology, and the Overall Health of Dairy Cows. [PDF]

Pathogens
Al-Shammari M, Alanazi IO, Alzahrani M, Alotaibi S, Alkahtani N, Alaqil A, Al-Olayan E.   +6 more
europepmc   +1 more source