Results 51 to 60 of about 1,966,233 (256)

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

OSCILLATION OF SOMATIC CELL COUNT IN MILK OF RECORDED COWS IN SLOVENIA IN YEARS 1997-2007 [PDF]

, 2008
Oscilacija u broju somatskih stanica (SCC) kod kontroliranih krava proučavana je u Sloveniji u razdoblju od 1997. do 2007. godine. Tijekom 5.267.264 test dana mjerenja su obavljana pretežno za simentalsku (42,4%), zatim za crno-bijelu (37,7%) i smeđu ...
M. Klopčić, M. Klinkon, Osterc, J., Klopčić, M., J. Osterc, Klinkon, M.   +5 more
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

EFFECTS OF MONTH AND YEAR OF CALVING ON 305-DAY MILK YIELD IN HOLSTEIN-FRIESIAN CATTLE IN NWFP, PAKISTAN

Pakistan Veterinary Journal, 2002
Data on production performance of 90 imported Dutch Holstein-Friesian cattle and their 127 Pakistani- born progeny from 1982 to 1991 were analyzed. The mean first lactation 305-day milk yield for imported and Pakistani-born cows was 3196.7 ± 66.36 and ...
Asad Ullah Hyder and Samee Ullah1
doaj  

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Genetic studies on various production and reproduction traits of Sahiwal and crossbred cattle (HFxJerseyxSahiwal) of an organised farm

Veterinary World, 2010
The present investigation was undertaken on data of 30 Sahiwal cattle and 30 crossbred cattle (HF × Jersey × Sahiwal) from Instructional Dairy Farm (IDF), G.B. Pant University of Agriculture & Technology, Pantnagar, Uttarakhand.
Anjan Dandapat, Dipak Banerjee, Dibyendu Chakraborty   +2 more
doaj  

A hierarchical 3-level meta-analysis of the effect of arginine supplementation on lactational performance in dairy cows and the associated influencing factors

Journal of Dairy Science
: Arginine is one of the most versatile among the AA because of its important role in multiple functions of the body. However, the effect of Arg supplementation on lactational performance in dairy cows, and the associated influencing factors, have not ...
Xiuli Li, Xiaowen Wang, Le Sun, Minjia He, Luzhen Wang, Dengpan Bu, Lianbin Xu   +6 more
doaj   +1 more source

Effects of pregnancy on daily milk yield of Holstein-Friesian dairy cattle

, 2004
First, second and third lactation curves of 21,885 first lactation dairy cows were allowed to vary depending on the months in milk at which the cow became pregnant. The curves were modelled using a 4th degree polynomial of days in milk. In the models for
Brotherstone, S., White, I. M. S., Thompson, R.   +2 more
core   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Effect of pre-calving body condition score and previous lactation on BCS change, blood metabolites, oxidative stress and milk production in Holstein dairy cows

Italian Journal of Animal Science, 2017
The aim of study was to determine the effect of pre-calving body condition score (BCS) and previous milk yield on BCS change, blood metabolites, oxidative stress and milk production in Holstein cows.
Negin Jamali Emam Gheise, Ahmad Riasi, Ahmad Zare Shahneh, Pietro Celi, Seyed Mehdi Ghoreishi   +4 more
doaj   +1 more source