Results 91 to 100 of about 1,966,233 (256)

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

FEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang, Mingqiang Deng, Dongmei He, Diqin Lai, Dongjun Liu, Dengyong Zhu, Zhenhua Zhang, Peng Tang, Chuanman Zhou, Menghui Yin, Xichen Bao   +10 more
wiley   +1 more source

A covariance function for feed intake, live weight and milk yield estimated using a random regression model [PDF]

, 1999
To enable investigation of genetic variation during early lactation in heifers, multitrait covariance functions were used to describe genetic covariances among feed intake, live weight, and milk yield during the first 15 wk of lactation (n = 628). Random
Veerkamp, R. F., Thompson, R.
core   +1 more source

Exploring the influence of lactoferrin on wound healing and related signaling pathways: a systematic review

FEBS Open Bio, EarlyView.
Lactoferrin promotes wound healing by activating MAPK, PI3K/Akt, and extracellular matrix pathways, enhancing fibroblast remodeling, proliferation, and re‐epithelialization. These mechanisms highlight its therapeutic potential in inflammation control, tissue repair, and remodeling.
Morgana Lüdtke Azevedo, Kátia Cristiane Hall, Matheus dos Santos Fernandez, Geovanna Peter Corrêa, Rafael Guerra Lund   +4 more
wiley   +1 more source

Evaluating the effect of γ‐oryzanol on MASLD pathology using a medaka fish model

FEBS Open Bio, EarlyView.
This study explores a liver disease called MASLD, which is increasing worldwide and can lead to serious damage. Researchers used medaka fish instead of rodents to test a food compound, γ‐oryzanol. Fish fed this compound had less liver fat and healthier gut bacteria.
Yukako Ito, Haduki Asano, Ayano Ueki, Joe Sakamoto, Yasuhiro Kamei, Hayato Tokumoto, Ayaka Yazawa, Shigeki Kamitani   +7 more
wiley   +1 more source

Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA

FEBS Open Bio, EarlyView.
Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley   +1 more source

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source

EFFECT OF PROTEIN UNDEGRADED SUPPLEMENTATION ON PRODUCTION AND COMPOSITION OF MILK IN DAIRY COWS [PDF]

, 2010
This research was aimed to examine the effect of undegraded protein supplementation on nutrients intake, production and milk composition in dairy cows. The purpose of this research was to provide information on the undegraded protein supplementation to
Agus, A, Widyobroto, BP, Budhi, SPS
core   +1 more source

Trends in milk production, calving rate and survival of cows in 14 Irish dairy herds as a result of the introgression of Holstein-Friesian genes [PDF]

, 2006
peer-reviewedTrends in milk production, calving rates, and survival were monitored on a potential 5580 primiparous and multiparous Holstein-Friesian dairy cows across 14 Irish seasonal spring-calving dairy farms between the years 1990 and 2001. Over this
V. Ducrocq, P. Dillon, Garrick, Dorian J., F. Buckley, D. P. Berry, D. J. Garrick, Dillon, Pat, M. Wallace, R. D. Evans, Evans, R. D., Ducrocq, V., Buckley, Frank, Wallace, Michael, Berry, Donagh   +13 more
core   +1 more source

Salmonella enterica serovar typhi limits the potency of typhoid toxin and ADP‐ribosylating toxin AB to establish a persistent infection

FEBS Open Bio, EarlyView.
The two catalytic subunits of typhoid toxin dissociate from the holotoxin in the ER of an intoxicated cell, but only CdtB exits the ER to generate immunosuppressive effects. PltA is retained in the ER and sequestered from its cytosolic target, thus allowing the anti‐inflammatory effects of CdtB to promote intestinal colonization.
Maria C. Zabala‐Rodriguez, Juliette K. Tinker, Teresa Frisan, Taj Azarian, Ken Teter   +4 more
wiley   +1 more source

Quantitative Trait Loci Affecting Milk Production Traits in Finnish Ayrshire Dairy Cattle [PDF]

, 2003
A whole genome scan of Finnish Ayrshire was conducted tomap quantitative trait loci (QTL) affecting milk production. The analysis included 12 half-sib families containing a total of 494 bulls in a granddaughter design.
Virta, J, Virta, A, Kinos, R., Virta, A., Viitala, Sirja M., Viitala, S.M., de Koning, D. J., Vilkki, J H, Mäki-Tanila, Asko, Viitala, S M, Mäki-Tanila, A, Schulman, N F, Kinos, R, Vilkki, J. H., Schulman, Nina F., Elo, Kari, Viitala, S. M., Elo, K, Kinos, Riikka, Koning, D.J., de, Vilkki, Johanna, de Koning, D J, de Koning, Dirk-Jan, Virta, Anneli, Elo, K., Schulman, N. F., Virta, J., Schulman, N.F., Vilkki, J.H., Virta, Jouni, Mäki-Tanila, A., de Koning, D.J.   +31 more
core   +1 more source