Results 191 to 200 of about 577,018 (252)

Wearable Standalone Sensing Systems for Smart Agriculture

Advanced Science, EarlyView.
This review explores the development and application of wearable sensing systems for plant health monitoring. It examines different types of wearable plant sensors, including their design, working principles, and material choices, with an emphasis on their suitability for real‐world agricultural applications.
Dongpil Kim, Mohammad Zarei, Siyoung Lee, Hansol Lee, Giwon Lee, Seung Goo Lee   +5 more
wiley   +1 more source

Disturbing Cholesterol/Sphingolipid Metabolism by Squalene Epoxidase Arises Crizotinib Hepatotoxicity

Advanced Science, EarlyView.
Crizotinib induces excessive accumulation of squalene epoxidase (SQLE) by blocking its autophagic degradation. This accumulation disrupts cholesterol and sphingolipid metabolism, leading to hepatic steatosis or hepatocyte apoptosis, respectively. Autophagy activators, such as metformin, or SQLE enzymatic inhibitors, like terbinafine, possesses the ...
Hao Yan, Xiangliang Huang, Yourong Zhou, Yuan Mu, Shaoyin Zhang, Yashi Cao, Wentong Wu, Zhifei Xu, Xueqin Chen, Xiaochen Zhang, Xiaohong Wang, Xiaochun Yang, Bo Yang, Qiaojun He, Peihua Luo   +14 more
wiley   +1 more source

Mitofusin 1 Drives Preimplantation Development by Enhancing Chromatin Incorporation of Histone H3.3

Advanced Science, EarlyView.
MFN1 exerts its function partially through histone H3.3 in early embryos. MFN1 colocalizes with PADI6, and its deficiency results in compromised cytoplasmic lattices and ribosomal subunits, leading to declined H3.3 protein level. This, in turn, hinders the incorporation of H3.3 into the embryonic genome, thereby causing failure of male pronucleus ...
Xiao‐yan Shi, Yu Tian, Yu‐fan Wang, Yi‐ran Zhang, Ying Yin, Qing Tian, Lei Li, Bing‐xin Ma, Ximiao He, Li‐quan Zhou   +9 more
wiley   +1 more source

Metabolomic and Cellular Mechanisms of Drug‐Induced Ototoxicity and Nephrotoxicity: Therapeutic Implications of Uric Acid Modulation

Advanced Science, EarlyView.
Drug‐induced renal damage impairs uric acid excretion, causing its accumulation in the serum, which subsequently infiltrates the cochlea. Xanthine oxidase and the ABCG2 transporter, critical in uric acid metabolism and excretion, undergo pathological changes in renal tubular and cochlear stria vascularis cells.
Suhan Guo, Cheng Cheng, Yunhao Wu, Kaidi Shen, Depeng Zhang, Bin Chen, Xinyu Wang, Luping Shen, Qixiang Zhang, Renjie Chai, Guangji Wang, Fang Zhou   +11 more
wiley   +1 more source

M6A Modified miR‐31‐5p Suppresses M1 Macrophage Polarization and Autoimmune Dry Eye by Targeting P2RX7

Advanced Science, EarlyView.
The upregulation of FTO in autoimmune dry eye suppresses the recognition of pri‐miR‐31 by DGCR8, thereby inhibiting the maturation of miR‐31‐5p and reducing its inhibitory effect on the target gene P2RX7. The activation of P2RX7 subsequently triggers the p38 MAPK signaling pathway and increases the level of M1‐related genes, thus exacerbating the ...
Lu Zhao, Xuejia Li, Min Gao, Lin Liu, Binyun Ma, Xun Liu, Jiachen Zhang, Ruoxuan Liu, Bei Du, Ruihua Wei, Hong Nian   +10 more
wiley   +1 more source

In Vivo Reprogramming of Tissue‐Derived Extracellular Vesicles for Treating Chronic Tissue Injury Through Metabolic Engineering

Advanced Science, EarlyView.
Inspired by exercise‐induced metabolic rewiring and EV secretion, this study shows that in vivo metabolic engineering strategy can reprogram EV secretion pattern and simultaneously attenuate multiple tissue injury in CKD status, highlighting that it is a potential strategy for treating diverse chronic diseases.
Meng Zhao, Shuyun Liu, Yizhuo Wang, Peng Lou, Ke Lv, Tian Wu, Lan Li, Qianyi Wu, Jiaying Zhu, Yanrong Lu, Meihua Wan, Jingping Liu   +11 more
wiley   +1 more source

Development of MDM2‐Targeting PROTAC for Advancing Bone Regeneration

Advanced Science, EarlyView.
This work presents a creative pipeline for developing MDM2‐targeting PROTACs (MDM2‐PROTACs) for application in bone regeneration. The developed PROTACs (CL144 and CL174) are validated for their degradation efficiency and osteogenic effects in human BMSCs.
Sol Jeong, Jae‐Kook Cha, Wasim Ahmed, Jaewan Kim, Minsup Kim, Kyung Tae Hong, Wonji Choi, Sunjoo Choi, Tae Hyeon Yoo, Hyun‑Ju An, Seung Chan An, Jaemin Lee, Jimin Choi, Sun‐Young Kim, Jun‐Seok Lee, Soonchul Lee, Junwon Choi, Jin Man Kim   +17 more
wiley   +1 more source

Targeted Delivery of α‐ketoglutarate to Macrophages in Bone: A Novel Therapeutic Strategy for Improving Fracture Healing in Type 2 Diabetes

Advanced Science, EarlyView.
The study reveals that glutaminolysis in macrophages is inhibited under type 2 diabetes mellitus (T2DM) conditions, which impedes fracture healing by reducing bone morphogenetic protein 2 (BMP2) production through increased cytosine methylation on the promoter.
Jing Wang, Jiahao Cao, Siqi Zhang, Hongli Chen, Xuebing Yu, Xinli Wang, Tianji Wang, Wei Cao, Wengang Dong, Xinsen Lin, Jia Li, Wei Lei, Yafei Feng   +12 more
wiley   +1 more source

LIMA1 O‐GlcNAcylation Promotes Hepatic Lipid Deposition through Inducing β‐catenin‐Regulated FASn Expression in Metabolic Dysfunction‐Associated Steatotic Liver Disease

Advanced Science, EarlyView.
Early diagnosis and treatment of metabolic dysfunction‐associated steatotic liver disease (MASLD) remains a significant challenge. This study indicates that serum sEV LIMA1 may serve as a noninvasive biomarker for MASH. The HCF1/OGT complex induces O‐GlcNAcylation of the LIMA1 protein, and subsequently promotes lipid accumulation in hepatocytes by ...
Fuji Yang, Yifei Chen, Guojun Zheng, Kefeng Gu, Lin Fan, Tingfen Li, Ling Zhu, Yongmin Yan   +7 more
wiley   +1 more source

Viridicatol from the Deep‐Sea‐Derived Fungus Alleviates Bone Loss by Targeting the Wnt/SHN3 Pathway

Advanced Science, EarlyView.
Viridicatol (VDC), isolated from the deep‐sea‐derived fungus, enhances osteogenesis in vitro and in vivo by targeting Wnt/SHN3 signaling pathway. It can be delivered via engineered nanovesicles to mitigate bone loss of osteoporosis, fracture repair, and osteogenesis imperfecta.
Chun‐Lan Xie, Shang‐Hui Ye, Yu‐Ting Yue, Bao‐Hong Shi, Jing‐Ping Xu, Lian‐Jie Li, Zheng‐Biao Zou, Matthew B. Greenblatt, Na Li, Xian‐Wen Yang, Ren Xu   +10 more
wiley   +1 more source