Advanced Science, EarlyView.In contrast to the adult mammalian heart, which lacks regenerative capacity, the neonatal heart retains a transient regenerative capacity. In this study, high mobility group box 2 (HMGB2) is identified as a crucial protein driving heart regeneration based on comprehensive analyses using quantitative proteomics with tandem mass tag (TMT) labelling, RNA ...
Liu‐Hua Zhou +17 more
wiley +1 more source
Biological Characteristics of <i>Dasineura jujubifolia</i> and Its Parasitoid Natural Enemies in Hami Region of Xinjiang (China). [PDF]
InsectsLi K, Ge Z, Zhang Z, Nie Y, Hu H.
europepmc +1 more source
Advanced Science, EarlyView.This study presents an engineered human interferon‐lambda (hIFN‐λ) as an intranasal prophylactic against respiratory viruses. By combining AI‐guided backbone redesign and glycoengineering, the authors developed a thermostable, protease‐resistant, and scalable variant with improved mucosal penetration.
Jeongwon Yun +12 more
wiley +1 more source
The GD-1 Stellar Stream Perturber as a Core-collapsed Self-interacting Dark Matter Halo. [PDF]
Astrophys J LettZhang X, Yu HB, Yang D, Nadler EO.
europepmc +1 more source
Advanced Science, EarlyView.The SNARE protein YKT6 is upregulated in bladder cancer (BLCA), correlating with poor prognosis. YKT6 promotes tumor proliferation and metastasis by activating Wnt/β‐catenin signaling. It recruits Ubiquitin‐Specific Peptidase 7 (USP7) to deubiquitinate and stabilize β‐catenin, enhancing its nuclear accumulation and driving oncogenic gene expression ...
Sheng Tu +16 more
wiley +1 more source
First Gaia dynamical model of the Milky Way disc with six phase space coordinates: a test for galaxy dynamics [PDF]
, 2020 M. S. Nitschai +2 more
openalex +1 more source
Postoperative adhesion formation: the role of peritoneal macrophages and targeting therapy. [PDF]
Front ImmunolLiu ZY, Li RF, Qin HY, Ma PF.
europepmc +1 more source
NDST3‐Induced Epigenetic Reprogramming Reverses Neurodegeneration in Parkinson's Disease
Advanced Science, EarlyView.NDST3‐mediated epigenetic reprogramming revitalizes neuronal circuits in the substantia nigra and striatum to halt dopaminergic neuron degeneration and restore motor function in Parkinson's disease models. This strategy promotes neuronal maintenance and functional recovery, highlighting NDST3's therapeutic potential in neurodegenerative disorders ...
Yujung Chang +18 more
wiley +1 more source
"He is my savior, my guiding light in the dark": imagination and domestication in Chinese women's romantic relationships with AI companions. [PDF]
Front PsycholHuang L, Zou W, Huang Y.
europepmc +1 more source
A computational method to dissect colonization resistance of the gut microbiota against pathogens. [PDF]
Cell Rep Methods, 2023 Ke S +5 more
europepmc +1 more source