Results 211 to 220 of about 43,519 (315)

A Dual Approach with Organoid and CRISPR Screening Reveals ERCC6 as a Determinant of Cisplatin Resistance in Osteosarcoma

Advanced Science, EarlyView.
This study utilizes patient‐derived osteosarcoma organoids and CRISPR screening to identify ERCC6 and HNRNPM as key mediators of cisplatin resistance via the PI3K/AKT pathway and BAX alternative splicing. These findings provide novel insights and potential therapeutic targets for overcoming chemoresistance in osteosarcoma.
Ruiling Xu, Sai Zhu, Wenchao Zhang, Haodong Xu, Chao Tu, Honghui Wang, Lu Wang, Na He, Tang Liu, Xiaoning Guo, Xiaolei Ren, Zhihong Li   +11 more
wiley   +1 more source

Molecular mechanisms of metastatic peritoneal dissemination in gastric adenocarcinoma. [PDF]

Cancer Metastasis Rev
Ng D, Cyr D, Khan S, Dossa F, Swallow C, Kazazian K.   +5 more
europepmc   +1 more source

Dynamics of the Outer Arm high-velocity cloud and the triaxiality of the Milky Way [PDF]

, 1992
U. Haud
openalex   +1 more source

The Evolutionary Trajectory and Prognostic Value of GITR+ Tregs Reprogramed by Tumor‐Intrinsic PD‐1/c‐MET Signaling in Pancreatic Cancer

Advanced Science, EarlyView.
In pancreatic ductal adenocarcinoma (PDAC), tumor‐intrinsic PD‐1 signaling activates the MET pathway, leading to the establishment of an immunosuppressive tumor microenvironment (TME). This MET‐driven signaling cascade promotes the selective accumulation of GITR+ regulatory T cells (Tregs), a highly immunosuppressive subset.
Jiande Han, Hanlin Yin, Taochen He, Junyi He, Zhenlai Jiang, Qiangda Chen, Zhihang Xu, Yuqi Xie, Yaolin Xu, Haibo Wang, Wenquan Wang, Wenchuan Wu, Yun Jin, Wenhui Lou, Jun Yu, Ning Pu, Liang Liu   +16 more
wiley   +1 more source

China completes world's largest ground-based network for space weather monitoring. [PDF]

Natl Sci Rev
Xin L.
europepmc   +1 more source

SALSA is an ICT Based Educational Tool for Astrophysics Students to Study Structure and Dynamics of Milky Way Galaxy

, 2018
Mir Sakhawat Hossain, Banrupa Mallik
openalex   +2 more sources

Formation history, structure and dynamics of discs and spheroids in simulated Milky Way mass galaxies [PDF]

, 2011
Cecilia Scannapieco, Simon D. M. White, Volker Springel, P. B. Tissera   +3 more
openalex   +1 more source

Gastrula‐Premarked Posterior Enhancer Primes Posterior Tissue Development Through Cross‐Talk with TGF‐β Signaling Pathway

Advanced Science, EarlyView.
A gastrula‐premarked enhancer within the first intron of Cdx2 governs posterior embryonic development via both regulating Cdx2 expression in cis and coordinating TGF‐β signaling in trans to ensure proper posterior body development. Functional rescue in gastruloids reveals a Cdx2‐independent pathway, highlighting p‐Enh‐eRNA as key epigenetic ...
Yingying Chen, Fengxiang Tan, Qing Fang, Lin Zhang, Jiaoyang Liao, Penglei Shen, Yun Qian, Mingzhu Wen, Rui Song, Yonggao Fu, He Jax Xu, Ran Wang, Cheng Li, Zhen Shao, Jinsong Li, Naihe Jing, Xianfa Yang   +16 more
wiley   +1 more source

Risk Prevention and Quality Control in Camel Milk Collection: Insights from Field Research. [PDF]

Foods
Yang H, Er D, Liu Y, Ling H, Ge R.
europepmc   +1 more source

THE INFLUENCE OF GAS DYNAMICS ON MEASURING THE PROPERTIES OF THE BLACK HOLE IN THE CENTER OF THE MILKY WAY WITH STELLAR ORBITS AND PULSARS [PDF]

, 2012
Dimitrios Psaltis
openalex   +1 more source