Results 201 to 210 of about 75,563 (322)

Okanin Suppresses the Growth of Colorectal Cancer Cells by Targeting at Peroxiredoxin 5

Advanced Science, EarlyView.
Okanin suppresses colorectal cancer growth by directly targeting PRDX5. This natural compound selectively binds peroxiredoxin 5 (PRDX5), inhibiting its activity and inducing WSB1‐mediated degradation. PRDX5 loss elevates ROS, suppresses GPX4 via SIAH2, and further triggers cell death (apoptosis and ferroptosis).
Ji Zhong Zhao, Yuan Fei Li, Fu Kang Yuan, Meng Lu Zhao, Ya Wen Han, Jia Xin Wang, Qi Yang, Han Ying Ye, Yu Cheng Lu, Shao Chin Lee   +9 more
wiley   +1 more source

An interstellar mission to test astrophysical black holes. [PDF]

iScience
Bambi C.
europepmc   +1 more source

Regular versus Irregular Exercise Differentially Modulates Hippocampal‐Hepatic Acetylcholine Flux to Coordinate Fear Memory Extinction and Liver Inflammation

Advanced Science, EarlyView.
Ma et al. report the hippocampal and hepatic acetylcholine (ACh) levels are differently modulated by regular versus irregular exercise, which contributes to coordinate hippocampal astrocyte activity and hepatic FBXL6high neutrophil recruitment. This ACh‐modulated brain‐liver circuit links the effects of exercise on fear memory extinction and liver ...
Pengjiao Ma, Kuan Zhang, Long Yi, Chuanyan Yang, Hedong Lang, Jianbin Sun, Jin Li, Qian Bai, Yuhang He, Shuang‐Shuang Dai, Man‐Tian Mi   +10 more
wiley   +1 more source

Bogong moths use a stellar compass for long-distance navigation at night. [PDF]

Nature
Dreyer D, Adden A, Chen H, Frost B, Mouritsen H, Xu J, Green K, Whitehouse M, Chahl J, Wallace J, Hu G, Foster J, Heinze S, Warrant E.   +13 more
europepmc   +1 more source

A Milky Way-like barred spiral galaxy at a redshift of 3. [PDF]

Nature, 2023
Costantin L, Pérez-González PG, Guo Y, Buttitta C, Jogee S, Bagley MB, Barro G, Kartaltepe JS, Koekemoer AM, Cabello C, Corsini EM, Méndez-Abreu J, de la Vega A, Iyer KG, Bisigello L, Cheng Y, Morelli L, Arrabal Haro P, Buitrago F, Cooper MC, Dekel A, Dickinson M, Finkelstein SL, Giavalisco M, Holwerda BW, Huertas-Company M, Lucas RA, Papovich C, Pirzkal N, Seillé LM, Vega-Ferrero J, Wuyts S, Yung LYA.   +32 more
europepmc   +1 more source

A Gaia-Enceladus Analog in the EAGLE Simulation: Insights into the Early Evolution of the Milky Way

, 2019
Lucas Bignone, A. Helmi, P. B. Tissera
openalex   +1 more source

Yields from massive stars in binaries. Chemical evolution of the Milky Way disk [PDF]

E. Pepe, Marco Palla, F. Matteucci, E. Spitoni   +3 more
openalex   +2 more sources

Injectable BMSC‐Based Extracellular Matrix‐Mimicking Microtissue for Myocardial Infarction Repair

Advanced Science, EarlyView.
A novel injectable biomimetic extracellular matrix scaffold (JLSV) is designed for enhanced delivery of bone marrow‐derived mesenchymal stem cells (BMSCs). By utilizing janus basic nanotubes, laminin, stromal‐derived factor‐1 alpha, and vascular endothelial growth factor, this innovative JLSV–BMSC microtissue shows promise in myocardial infarction ...
Lina Yao, Huailong An, Cong Fan, Qingsu Lan, Hongyu Zhong, Yun Zhang, Libo Zhou, Panpan Hao   +7 more
wiley   +1 more source

Milky Way could invalidate the hypothesis of exotic matter and favor a gravitomagnetic solution to explain dark matter. [PDF]

Sci Rep
Le Corre S.
europepmc   +1 more source

Microfilament‐Myosin II Regulates the Differentiation of Multinucleated Cysts into Oocytes and Influences Oocyte Developmental Potential in Mice

Advanced Science, EarlyView.
In this study, we provided new evidence identifying multinucleated cysts as precursors for oocyte differentiation. Within these cysts, organelles migrate and aggregate to form Balbiani body (B‐body) and establish early cellular polarity. Concurrently, excess nuclei are expelled, enabling cyst‐to‐oocyte differentiation. The microfilament‐myosin II plays
Rui Xu, Menghao Pan, Zhi Zheng, Yaju Tang, Yutong Yan, Sihai Lu, Sha Peng, Baohua Ma   +7 more
wiley   +1 more source