Results 251 to 260 of about 155,710 (341)

RONIN/HCF1‐TFEB Axis Protects Against D‐Galactose‐Induced Cochlear Hair Cell Senescence Through Autophagy Activation

Advanced Science, EarlyView.
D‐galactose (D‐gal) induced inner ear hair cell senescence by inhibiting TFEB transcription. RONIN/HCF1 promotes TFEB transcription to prevent cochlear HCs from D‐gal‐induced senescence through autophagy activation. Abstract Age‐related hearing loss is characterized by senescent inner ear hair cells (HCs) and reduced autophagy.
Yongjie Wei, Yuhua Zhang, Wei Cao, Nan Cheng, Yun Xiao, Yongjun Zhu, Yan Xu, Lei Zhang, Lingna Guo, Jun Song, Su‐hua Sha, Buwei Shao, Fang Ma, Jingwen Yang, Zheng Ying, Zuhong He, Renjie Chai, Qiaojun Fang, Jianming Yang   +18 more
wiley   +1 more source

Laticifers are present in Acalyphoideae after all: new insights from leaf anatomy with implications for the systematics and evolution of Euphorbiaceae. [PDF]

AoB Plants
Mouzella CP, Sousa AA, Caruzo MBR, Montero-Muñoz I, Meira RMSA, Riina R.   +5 more
europepmc   +1 more source

Elevated Histone Lactylation Mediates Ferroptosis Resistance in Endometriosis Through the METTL3‐Regulated HIF1A/HMOX1 Signaling Pathway

Advanced Science, EarlyView.
This study reveals that histone lactylation, a modification derived from lactate, plays a crucial role in ferroptosis resistance in ectopic endometrial stromal cells. This resistance is mediated via the HIF1A/HMOX1 pathway regulated by METTL3. In vivo, a combination of 2‐DG and erastin shows promise as an effective treatment for endometriosis ...
Zongwen Liang, Jinming Liu, Yanling Gou, Honglin Wang, Zhi Li, Yingying Cao, Huiyan Zhang, Ruru Bai, Zongfeng Zhang   +8 more
wiley   +1 more source

A probable Keplerian disk feeding an optically revealed massive young star. [PDF]

Nature
McLeod AF, Klaassen PD, Reiter M, Henshaw J, Kuiper R, Ginsburg A.   +5 more
europepmc   +1 more source

Inside-out versus Upside-down: The Origin and Evolution of Metallicity Radial Gradients in FIRE Simulations of Milky Way-mass Galaxies and the Essential Role of Gas Mixing [PDF]

Russell L. Graf, Andrew Wetzel, Jeremy Bailin, M. Orr   +3 more
openalex   +1 more source

Early chemical evolution of the Milky Way [PDF]

Proceedings of the International Astronomical Union, 2005
openaire   +2 more sources

Pinoresinol Diglucoside Attenuates Nuclear Receptor Coactivator 4‐Mediated Ferritinophagy Associated with Cisplatin‐Induced Hearing Loss

Advanced Science, EarlyView.
Pinoresinol diglucoside, a bioactive component extracted from traditional Chinese medicine, attenuates cisplatin‐induced ototoxicity in vivo and in vitro. The protective effect is achieved by downregulation of Socs1. The present study is the first to investigate the expression and function of Socs1 in inner ear, which is known to promote ferroptosis ...
Yin Chen, Cheng Cheng, Ao Li, Dengbin Ma, Siyu Li, Handong Wang, Song Gao, Dingding Liu, Panpan Song, Chenjie Yu, Xiaoyun Qian, Guoqiang Wan, Xia Gao   +12 more
wiley   +1 more source

Ultrafast Laser Synthesis of Zeolites. [PDF]

Adv Mater
Galioglu S, Hagverdiyev M, Doğan MM, Yavuz Ö, Nizam ÜS, Makey G, Şura A, Laçin M, Kurç BA, Elahi P, Ilday FÖ, Ilday S.   +11 more
europepmc   +1 more source

Long‐Lasting Auditory and Vestibular Recovery Following Gene Replacement Therapy in a Novel Usher Syndrome Type 1c Mouse Model

Advanced Science, EarlyView.
This study shows that gene replacement therapy using the AAV2/Anc80L65 virus can successfully restore hearing and balance in Ush1c knockout mice. The treatment leads to lasting improvements in both auditory and vestibular functions, highlighting its potential as a therapeutic approach for genetic hearing loss and vestibular disorders in humans ...
Weinan Du, Jun Huang, Aizhen Zhang, Fangfang Zhao, Tianwen Chen, Quinn M. McDermott, Tony Zheng, Haibo Wang, Rongli Zhang, Xiaolin Zhang, Jerome Allison, Hong Zhu, Wu Zhou, Qing Yin Zheng   +13 more
wiley   +1 more source

Atacama Large Aperture Submillimeter Telescope (AtLAST) science: The hidden circumgalactic medium. [PDF]

Open Res Eur
Lee M, Schimek A, Cicone C, Andreani P, Popping G, Sommovigo L, Appleton PN, Bischetti M, Cantalupo S, Chen CC, Dannerbauer H, De Breuck C, Di Mascolo L, Emonts BHC, Hatziminaoglou E, Pensabene A, Rizzo F, Rybak M, Shen S, Lundgren A, Booth M, Klaassen P, Mroczkowski T, Cordiner MA, Johnstone D, van Kampen E, Liu D, Maccarone T, Saintonge A, Smith M, Thelen AE, Wedemeyer S.   +31 more
europepmc   +1 more source