Results 271 to 280 of about 155,710 (341)

Cathepsin K Aggravates Pulmonary Fibrosis Through Promoting Fibroblast Glutamine Metabolism and Collagen Synthesis

Advanced Science, EarlyView.
CTSK plays a critical role in pulmonary fibrosis. Excessive CTSK accumulation interacts with SNX9 to enhance TGF‐β1‐induced SMAD3 activation and GLS1 expression in fibroblasts, driving glutamine metabolism for collagen biosynthesis and exacerbating pulmonary fibrosis.
Mengting Chen, Xiaoxiao Meng, Yong Zhu, Dapeng Wang, Mengmeng Wang, Ziyuan Wang, Xue Tian, Jiaxiang Zhang, Zhiying Yue, Zhengfeng Yang, Ruilan Wang   +10 more
wiley   +1 more source

Bound star clusters observed in a lensed galaxy 460 Myr after the Big Bang. [PDF]

Nature
Adamo A, Bradley LD, Vanzella E, Claeyssens A, Welch B, Diego JM, Mahler G, Oguri M, Sharon K, Abdurro'uf, Hsiao TY, Xu X, Messa M, Lassen AE, Zackrisson E, Brammer G, Coe D, Kokorev V, Ricotti M, Zitrin A, Fujimoto S, Inoue AK, Resseguier T, Rigby JR, Jiménez-Teja Y, Windhorst RA, Hashimoto T, Tamura Y.   +27 more
europepmc   +1 more source

LincNEAT1 Encoded‐NEAT1‐31 Promotes Phagocytosis by Directly Activating the Aurora‐A–PI3K–AKT Pathway

Advanced Science, EarlyView.
LincNEAT1 Encoded‐NEAT1‐31 micropeptide directly binds with Aurora‐A and enhanced AKT pathways to pormotes phagocytosis against multi cancer cells. Abstract Macrophages play vital roles in innate and adaptive immunity, and their essential functions are mediated by phagocytosis and antigen presentation.
Jie Li, Jing Zhang, Xixi Li, Xin Liu, Bo Zeng, Jiayue Luo, Huijin Wang, Hanbing Zhang, Xinya Gao   +8 more
wiley   +1 more source

Atacama Large Aperture Submillimeter Telescope (AtLAST) science: Our Galaxy. [PDF]

Open Res Eur
Klaassen P, Traficante A, Beltrán M, Pattle K, Booth M, Lovell J, Marshall J, Hacar A, Gaches B, Bot C, Peretto N, Stanke T, Arzoumanian D, Duarte Cabral A, Duchêne G, Eden D, Hales A, Kauffmann J, Luppe P, Marino S, Redaelli E, Rigby A, Sánchez-Monge Á, Schisano E, Semenov D, Spezzano S, Thompson M, Wyrowski F, Cicone C, Mroczkowski T, Cordiner M, Di Mascolo L, Johnstone D, van Kampen E, Lee M, Liu D, Maccarone T, Saintonge A, Smith M, Thelen A, Wedemeyer S.   +40 more
europepmc   +1 more source

Star Formation and Chemical Evolution in the Milky Way: Cosmological Implications

, 1998
Nikos Prantzos, Joseph Silk
openalex   +1 more source

PROS1‐MERTK Axis Drives Tumor Microenvironment Crosstalk and Progression in Papillary Thyroid Microcarcinoma

Advanced Science, EarlyView.
Identifying biomarkers associated with PTC, particularly those related to PTMC progression, is crucial for precise risk stratification and treatment planning. This study utilized single‐cell RNA sequencing on 19 surgical tissue specimens, confirmed PROS1/MERTK axis as a critical component of the cellular microenvironment and a key regulatory mechanism ...
Wenqian Zhang, Ye Zhang, Zhu Liu, Zhiyuan Wang, Huaqin Wang, Xiaoyu Ji, Hongyue Su, Fan Yang, Lirong Yan, Ying Xu, Hao Zhang, Wei Sun   +11 more
wiley   +1 more source

Metabolomics and sensory evaluation combined analysis reveal the effect of processing methods and different forms on the flavor of rose herbal tea. [PDF]

NPJ Sci Food
Zhao Y, Peng Q, Chang L, Wang Z, Lin Z, Shi J, Dong C.   +6 more
europepmc   +1 more source

Abundance evolution of intermediate mass elements (C to Zn) in the Milky Way halo and disk

, 2000
Aruna Goswami, Nikos Prantzos
openalex   +2 more sources

The LDH‐H3K18La‐Nur77 Axis Potentiates Immune Escape in Small Cell Lung Cancer

Advanced Science, EarlyView.
Lactate from SCLC tumors induces H3K18 lactylation in naïve CD8+ T cells, upregulating Nurr77 and enhancing tonic TCR signaling. This leads to T cell hyporesponsiveness to stimulation, impairing antitumor immunity and reducing immunotherapy efficacy.
Xiaoling Shang, Bo Cheng, Chenyue Zhang, Chenglong Zhao, Ruiqing Wang, Xun Zhang, Dizhi Jiang, Xinyu Zhang, Xinyue Ma, Hongyuan Mao, Zerun Li, Chenhan Huang, Tianzi Wang, Kaiyue Guo, Liwen Wang, Ning Tang, Haiyong Wang   +16 more
wiley   +1 more source

Abundant water from primordial supernovae at cosmic dawn. [PDF]

Nat Astron
Whalen DJ, Latif MA, Jessop C.
europepmc   +1 more source