Results 271 to 280 of about 77,216 (325)
The Tumor‐to‐Endothelial Transfer of FTO Promotes Vascular Remodeling and Metastasis in Nasopharyngeal Carcinoma
Advanced Science, EarlyView.Integrated omics analysis of matched primary and liver metastatic NPC tumors reveals a unique NOTCH1+ CSC subpopulation exhibiting enhanced stemness properties and tumorigenic capacity. With in vitro and in vivo assays, exosomal transfer of tumor‐derived FTO from NOTCH1+ cells to the endothelium promotes vascular permeability and metastatic potential ...Chun Wu, Xuefei Liu, Liwen Gu, Jingru Lian, Yuting Wang, Yixin Cheng, Lianhui Duan, Guanyin Huang, Siqi Chen, Boxi Zhao, Sailan Liu, Yufan Yang, Shuqian Zheng, Zijian Lu, Wanping Guo, Jianyang Hu, Wenjing Wang, Zhixiang Zuo, Haiqiang Mai, LinQuan Tang, Songfa Zhang, Feiqiu Wen, Xin Hong, Ling Guo +23 morewiley +1 more sourceEndometrial Assembloid Model Reveals Endometrial Gland Development Regulation by Estradiol‐Driven WNT7B Suppression
Advanced Science, EarlyView.This study developed a 3D endometrial assembloid model to study how uterine glands form and develop. They discovered key interactions between different cell types and identified WNT7B as a regulator controlled by estradiol‐mediated TGFβ1‐VDR interaction.Xintong Li, Yanjie Guo, Jianlin Li, Yimeng Li, Leqian Lin, Hoi Kit Matthew Leung, Qingqing Zhang, Kai‐Fai Lee, Ka‐Wang Cheung, Ernest H. Y. Ng, William S. B. Yeung, Philip C. N. Chiu, Cheuk‐Lun Lee +12 morewiley +1 more sourceTRIM56 Aggravates Cerebral Ischemia‐Reperfusion Injury via Inhibiting KLF4‐Activated Ferroptosis Signaling
Advanced Science, EarlyView.This study reveals that the E3 ubiquitin ligase TRIM56 exacerbates neuronal ferroptosis and brain damage by mediating K48‐linked ubiquitination and degradation of KLF4, leading to suppression of the xCT/GSH/GPX4 axis. Targeting TRIM56 alleviates cerebral ischemia‐reperfusion injury in vivo and in vitro, highlighting its therapeutic potential.Qiangping Wang, Shuang Li, Man Li, Wenke Zhou, Jianqing Zhang, Zhenfu Wu, Zhaoqi Mao, Juan Wan, Xinhao Tang, Baoping Zheng, Qiang Liu, Zhendong Li, Xiaobing Jiang, Qingping Wu, Youfan Ye, Haijun Wang +15 morewiley +1 more sourceArtificial Tactile Perception System for Exploring Internal and External Features of Objects via Time‐Frequency Features
Advanced Science, EarlyView.By engaging in different active exploration behaviors, the tactile perception system can generate distinct signal modes, enabling the application of targeted decoding strategies for efficient and accurate perception of both external and internal object features.Yuanzhi Zhou, Jingqi Zhang, Linyi Li, Muxing Huang, Ziyi Zhang, Xingmin Lu, Zilan Li, Xuchun Gui, Xinming Li +8 morewiley +1 more sourceAtacama Large Aperture Submillimeter Telescope (AtLAST) science: The hidden circumgalactic medium. [PDF]
Open Res EurLee M, Schimek A, Cicone C, Andreani P, Popping G, Sommovigo L, Appleton PN, Bischetti M, Cantalupo S, Chen CC, Dannerbauer H, De Breuck C, Di Mascolo L, Emonts BHC, Hatziminaoglou E, Pensabene A, Rizzo F, Rybak M, Shen S, Lundgren A, Booth M, Klaassen P, Mroczkowski T, Cordiner MA, Johnstone D, van Kampen E, Liu D, Maccarone T, Saintonge A, Smith M, Thelen AE, Wedemeyer S. +31 moreeuropepmc +1 more sourceComprehensive Profiling of N6‐methyladnosine (m6A) Readouts Reveals Novel m6A Readers That Regulate Human Embryonic Stem Cell Differentiation
Advanced Science, EarlyView.This research deciphers the m6A transcriptome by profiling its sites and functional readout effects: from mRNA stability, translation to alternative splicing, across five different cell types. Machine learning model identifies novel m6A‐binding proteins DDX6 and FXR2 and novel m6A reader proteins FUBP3 and L1TD1.Zhou Huang, Rucong Liu, Zibaguli Wubulikasimu, Wanqing Zhao, Jiaqi Huang, Jiaxuan Wang, Tianyuan Zhang, Rui Fan, Wei Kong, Qinghua Cui, Yang Li, Yuan Zhou +11 morewiley +1 more sourceGLObal Solar Wind Structure (GLOWS). [PDF]
Space Sci RevBzowski M, Wawrzaszek R, Strumik M, Baran J, Barciński T, Ber K, Bujwan W, Daukszo M, Jasiński K, Juchnikowski G, Kazmierczak P, Kowalska-Leszczyńska I, Kowalski T, Kubiak M, Ma̧dry J, Mirońska A, Mostowy K, Orleański P, Porowski C, Półtorak J, Rajkowski T, Rothkaehl J, Rudnicki T, Shmyk A, Sikorski A, Turek M, Winkler M, Wojciechowska K, Zawistowski T, Fahr HJ, Nass U, Osica P, Wielgos K, Gottwald A, Kaser H, Krzyzagorski M, Antoniak M, Drobik M, Gajoch G, Martyniak T, Żogała R, Bartnik A, Fiedorowicz H, Fok T, Majszyk M, Wachulak P, Wardzińska M, Wȩgrzyński Ł, Kosturek R, Urdiales C, Tapley M, Pope S, Reisenfeld DB, Gkioulidou M, Schwadron NA, Christian ER, McComas DJ. +56 moreeuropepmc +1 more sourcePLA2G16‐Mediated Tetracosatetraenoic Acid Rewires Fatty Acid Oxidation to Impair CD8+ T Cell Immune Function in Promoting Breast Cancer Lung Metastasis
Advanced Science, EarlyView.Illustrating how tumor‐derived PLA2G16 regulates tetracosatetraenoic acid (C24:4 (n‐6)) accumulation and CD8+ T cell activation via the C24:4‐PPARα‐FAO axis in early metastatic niches, thereby promoting lung metastasis of triple‐negative breast cancer.Yubi Gan, Die Meng, Lei Lang, Jing Luo, Peijin Dai, Chao Chang, Zexiu Lu, Yuetong Guo, Rui Wang, Shanchun Chen, Xi Tang, Yixuan Hou, Dongmei Tan, Manran Liu +13 morewiley +1 more source
