Results 291 to 300 of about 155,710 (341)

Milky Way Influenced Phanerozoic Cycles, Proterozoic Episodes, Global Catastrophes, Climate and the Evolution of Life on Earth: Review and Analysis

Heinz-Jürgen Brink
openalex   +1 more source

Chronic Psychological Stress Induces Cardiomyocyte Hypertrophy Through Corticosterone‐Glucocorticoid Receptor‐LAMA5 Axis

Advanced Science, EarlyView.
In vivo experiments suggest that cardiomyocyte hypertrophy is an early manifestation of cardiac pathological changes induced by chronic psychological stress. In vivo and in vitro experiments suggest that the corticosterone‐glucocorticoid receptor‐LAMA5 axis mediates cardiomyocyte hypertrophy induced by chronic psychological stress. The clinical results
Chuanjing Zhang, Yongfei Song, Xiaojun Jin, Qingbo Xu, Honghua Ye, Zhuonan Wu, Hui Lin, Jiale Hu, Chen Huang, Jianqing Zhou, Jiangfang Lian   +10 more
wiley   +1 more source

A nearby dark molecular cloud in the Local Bubble revealed via H₂ fluorescence. [PDF]

Nat Astron
Burkhart B, Dharmawardena TE, Bialy S, Haworth TJ, Cruz Aguirre F, Jo YS, Andersson BG, Chung H, Edelstein J, Grenier I, Hamden ET, Han W, Hoadley K, Lee MY, Min KW, Müller T, Pattle K, Peek JEG, Pleiss G, Schiminovich D, Seon KI, Wilson AG, Zucker C.   +22 more
europepmc   +1 more source

PSMD14 Stabilizes SLC7A11 to Ameliorate Glucocorticoid‐Induced Osteoporosis by Suppressing Osteocyte Ferroptosis

Advanced Science, EarlyView.
Glucocorticoid‐induced osteoporosis (GIOP) triggers osteocyte ferroptosis via SLC7A11 degradation. PSMD14 stabilizes SLC7A11 by counteracting glucocorticoid‐driven ubiquitination, preserving cystine uptake and glutathione synthesis. AAV‐mediated PSMD14 delivery or its agonist Pantethine rescues osteocyte survival and bone loss in GIOP mice.
Yifeng Shi, Qian Tang, Sunren Sheng, Hongyi Jiang, Chen Jin, Chencheng Zhou, Chenglong Xie, Lin Zheng, Di Zhang, Hui Xu, Cong Xu, Haiwei Ma, Guangheng Xiang, Wenfei Ni, Xiaoyun Pan, Lei Yang, Huazi Xu, Yu Qian, Aimin Wu, Xiangyang Wang, Gang Zheng   +20 more
wiley   +1 more source

Development of Antimicrobial Coatings from <i>Ficus carica</i> Latex for Improving the Quality of Dried Figs. [PDF]

Foods
Gizaw Y, Casquete R, Del Carmen Caballero M, de Guía Córdoba M, Benito MJ.   +4 more
europepmc   +1 more source

Cosmological zoom-in simulation of fuzzy dark matter down to z = 0: tidal evolution of subhaloes in a Milky Way-sized halo

Hei Yin Jowett Chan, Hsi-Yu Schive, Victor H. Robles, Alexander Kunkel, Guan-Ming Su, Ping Liao   +5 more
openalex   +1 more source

CircTP53/USP10/p53 signaling Axis as a Novel Regulator of Progression and Prognosis of Head and Neck Squamous Cell Carcinoma

Advanced Science, EarlyView.
The study identifies a novel circular RNA derived from the TP53 gene (circTP53), which is upregulated in HNSCC and correlates with poor patient prognosis. It demonstrates that circTP53 promotes HNSCC progression by interacting with USP10, stabilizing both proteins, enhancing deubiquitination of p53, and thereby influencing tumor growth, with its ...
Yin Wang, Fen Chang, Zinan Li, Chengcheng Duan, Xiangkai Sun, Siyu Wang, Dongmin Wei, Wenming Li, Ye Qian, Shengda Cao, Juan Zhao, Dapeng Lei   +11 more
wiley   +1 more source

Flux equipartition in astrophysical plasma turbulence. [PDF]

Sci Adv
Marino R, Xie JH.
europepmc   +1 more source

Figuring Out Gas and Galaxies in Enzo (FOGGIE). IX. The Angular Momentum Evolution of Milky Way–like Galaxies and Their Circumgalactic Gas

Raymond C. Simons, Molly S. Peeples, Jason Tumlinson, Brian W. O’Shea, Cassandra Lochhaas, Anna C. Wright, Ayan Acharyya, Ramona Augustin, Kathleen A. Hamilton-Campos, Britton Smith, Nicolas Lehner, Jessica K. Werk, Yong Zheng   +12 more
openalex   +1 more source

The Non‐Coding Regulatory Variant rs2863002 at chr11p11.2 Increases Neuroblastoma Risk by Affecting HSD17B12 Expression and Lipid Metabolism

Advanced Science, EarlyView.
The SNP rs2863002 at the 11p11.2 locus, identified through GWAS, is associated with an increased risk of neuroblastoma. The rs2863002‐C allele impairs the binding of the transcription factor GATA3, resulting in upregulation of the HSD17B12 gene.
Teresa Maiorino, Marianna Avitabile, Vincenzo Aievola, Annalaura Montella, Vito A. Lasorsa, Ferdinando Bonfiglio, Mariagrazia Cantalupo, Sueva Cantalupo, Gilda Estinto, Matilde Tirelli, Martina Morini, Martina Ardito, Alessandra Eva, Vincenza Cerbone, Lucia Mauriello, Marianna Caterino, Margherita Ruoppolo, John M. Maris, Sharon J. Diskin, Achille Iolascon, Mario Capasso   +20 more
wiley   +1 more source