Results 141 to 150 of about 267,615 (357)

Cosmological pseudobulge formation

open access: yes, 2012
Bulges can be classified into classical and pseudobulges; the former are considered to be end products of galactic mergers and the latter to form via secular evolution of galactic disks.
Okamoto, Takashi
core   +1 more source

Development of 4T1 breast cancer mouse model system for preclinical carbonic anhydrase IX studies

open access: yesFEBS Open Bio, EarlyView.
Carbonic anhydrase IX (CAIX) is a well‐recognised therapeutic target and prognostic biomarker in cancer. We developed and characterised a robust murine breast cancer model system that is suitable for CAIX studies in vitro and in vivo—it comprises both CAIX‐positive and CAIX‐negative controls and provides a solid platform for the comprehensive ...
Zane Kalniņa   +13 more
wiley   +1 more source

The epoch of bar formation in the Milky Way

open access: yes, 2023
A key event in the life of the Milky Way is the formation of the bar. The Milky Way bar has restructured the disc, been slowed by the dark matter halo and funnelled gas towards the Galactic Centre. It is then important to know the period of time over which these processes have been effective.
openaire   +2 more sources

Constraining local UV field geometry at reionization using Milky Way satellites

open access: yes, 2011
We present a new semi-analytical model of the population of satellite galaxies of the Milky Way, aimed at estimating the effect of the geometry of reionization at galaxy scale on the properties of the satellites. In this model reionization can be either:
Aubert, D., Ocvirk, P.
core   +2 more sources

GDP‐fucose transporter SLC35C1: a potential regulatory role in cytosolic GDP‐fucose and fucosylated glycan synthesis

open access: yesFEBS Open Bio, EarlyView.
The inactivation of SLC35C1 (GDP‐fucose transporter) and enzymes involved in GDP‐fucose biosynthesis was studied. Fucose supplementation increases the level of GDP‐fucose to abnormal, millimolar values in the absence of the TSTA3 protein and SLC35C1 in contrast to the GMDS/SLC35C1 double mutant.
Edyta Skurska, Mariusz Olczak
wiley   +1 more source

Short peptide perturbs spermatogenesis via immune microenvironment dysregulation and mitochondrial imbalance

open access: yesFEBS Open Bio, EarlyView.
In the blood–testis barrier, occludin is crucial for tight junctions. This study demonstrates that occludin‐targeting short peptides disrupt junction integrity, inducing immune cell infiltration, tumor necrosis factor‐α/interleukin‐6 secretion and mitochondrial dysfunction, ultimately triggering apoptosis.
Heng Wang, Xiaofang Tan, Deyu Chen
wiley   +1 more source

The APO-K2 Catalog. II. Accurate Stellar Ages for Red Giant Branch Stars across the Milky Way

open access: yesThe Astronomical Journal
We present stellar age determinations for 4661 red giant branch stars in the APO-K2 catalog, derived using mass estimates from K2 asteroseismology from the K2 Galactic Archaeology Program and elemental abundances from the Apache Point Galactic Evolution ...
Jack T. Warfield   +13 more
doaj   +1 more source

Biophysical characterization and ion transport with cell‐based and proteoliposome reconstitution assays of invertebrate K+‐Cl− cotransporters

open access: yesFEBS Open Bio, EarlyView.
The K+‐Cl− cotransporters (KCCs) facilitate the symport of ions across the plasma membrane. They participate in physiological processes including neuronal regulation. Here, we characterized KCCs from Drosophila and Hydra vulgaris. Comparative analyses of transporters provide insights into the mechanism of KCC ion transport, regulation, and evolution ...
Satoshi Fudo   +4 more
wiley   +1 more source

Disk Assembly of the Milky Way Suggested from the Time-resolved Chemical Abundance

open access: yesThe Astrophysical Journal
Both simulations and observations suggest that the disk assembly of galaxies is governed by the interplay between coplanar gas inflow, ex-planar gas outflow, and in situ star formation on the disk, known as the leaky accretion disk.
Enci Wang   +3 more
doaj   +1 more source

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