Results 271 to 280 of about 90,260 (324)

Hypoxia‐Induced circPRELID2 Promotes Gastric Cancer Metastasis by Facilitating ZEB2 Translation via PCBP1 O‐GlcNAcylation

Advanced Science, EarlyView.
Under hypoxia, HIF1A is directly bound to the PRELID2 promoter to increase PRELID2 pre‐mRNA expression, followed by the DYRK1A–SFPQ–SAM68 complex binding to Alu‐containing introns in PRELID2 pre‐mRNA, leading to circPRELID2 circularization. CircPRELID2 interacts with PCBP1 and promotes its cytoplasmic retention.
Pengshan Zhang, Zai Luo, Yitian Xu, Yuan Zhang, Renchao Zhang, Nadina Paerhati, Shaopeng Zhang, Qianqian Cai, Zhengjun Qiu, Chen Huang   +9 more
wiley   +1 more source

Rapid Solidification of Plant Latices from <i>Campanula glomerata</i> Driven by a Sudden Decrease in Hydrostatic Pressure. [PDF]

Plants (Basel)
Langhoff A, Peschel A, Leppin C, Kruppert S, Speck T, Johannsmann D.   +5 more
europepmc   +1 more source

Resident Macrophage‐Orchestrated Immune and Fibroblast Interactions in Immune Checkpoint Inhibitor‐Associated Nephrotoxicity

Advanced Science, EarlyView.
Schematic illustration of resident macrophages in Immune checkpoint inhibitor‐associated nephrotoxicity (ICI‐AN). Using an integrated approach (including imaging mass cytometry, transcriptomics, and murine models), this study reveals that resident macrophages drive immune‐stromal interactions in ICI‐AN, promoting fibroblast activation through CXCL9 and
Yanhong Ma, Yang Chen, Qinfan Yao, Yuxi Wang, Nan Ouyang, Fei Han, Guzong Wang, Meifang Wang, Yuan Yuan, Jianghua Chen, Jianzhen Shan, Dajin Chen   +11 more
wiley   +1 more source

Molecular mechanisms of metastatic peritoneal dissemination in gastric adenocarcinoma. [PDF]

Cancer Metastasis Rev
Ng D, Cyr D, Khan S, Dossa F, Swallow C, Kazazian K.   +5 more
europepmc   +1 more source

ADAR1 as a Placental Innate Immune Rheostat Sustaining the Homeostatic Balance of Intrinsic Interferon Response at the Maternal‐Fetal Interface

Advanced Science, EarlyView.
This study reveals that ADAR1, an RNA‐editing enzyme, fine‐tunes immune responses in the placenta by preventing the accumulation of immunogenic double‐stranded RNAs (dsRNAs) from interferon‐stimulated genes. The loss of ADAR1 in the placenta leads to excessive interferon signaling restricted to the junctional zone, disrupting placental development and ...
Xiaogang Chen, Xiangchao Xu, Jiahao Chen, Huiru Zhang, Wanshan Zheng, Wenzhe Yu, Xiaoqian Hu, Bin Cao   +7 more
wiley   +1 more source

Reflections on the applicability of palliative thoracentesis in Primary Care. [PDF]

Aten Primaria
Ferreiro L, Toubes ME, Rodríguez-Núñez N, Valdés L.   +3 more
europepmc   +1 more source

Electron Transfer‐Tailored D‐Band Center to Boost Nanozyme Catalysis for Interpretable Machine Learning‐Empowered Intelligent Biosensing

Advanced Science, EarlyView.
This study pioneers a rational nanozyme design strategy guided by electron transfer mechanisms while advancing biosensing paradigms through interpretable machine learning‐enhanced signal intelligence. By transforming biosensors from passive transducers to active diagnostic systems, this work establishes a versatile framework for addressing global ...
Yuechun Li, Chenxin Ji, Zhaowen Cui, Jianxing Feng, Liang Zhang, Sha Liu, Wentao Zhang, Yanwei Ji, Yizhong Shen, Jianlong Wang   +9 more
wiley   +1 more source

Immune cell changes in Helicobacter pylori infection-induced glandular epithelial cell damage of the gastric mucosa. [PDF]

Ann Med
Wang SN, Yun T, Zhu CY, Li P, Ge DF, Li SL, Wang YK.   +6 more
europepmc   +1 more source

Stimuli‐Responsive CuFeTe2 Nanosheets for Amplified Cuproptosis/Ferroptosis in Triple‐Negative Breast Cancer Therapy

Advanced Science, EarlyView.
Dual‐stimuli‐responsive CuFeTe2 nanosheets (CFT) induce cuproptosis/ferroptosis via TME‐responsive Fe2⁺/Cu2⁺ release and NIR‐II photothermal effects, amplifying ROS and depleting HSP70/ATP to trigger ICD and immune activation, while ensuring biocompatible renal clearance for TNBC therapy.
Molin Liu, Jian Zheng, Mengqi Yu, Qirui Wang, Yi Yuan, Nannan Shao, Xiaoliang Yang, Tianxi Shen, Li Wang, Aiyun Li, Rui Liu, Jimin Cao, Xi Liu, Fangfang Cao, Yanlin Feng   +14 more
wiley   +1 more source

Evidence of star cluster migration and merger in dwarf galaxies. [PDF]

Nature
Poulain M, Smith R, Duc PA, Marleau FR, Habas R, Durrell PR, Fensch J, Lim S, Müller O, Paudel S, Sánchez-Janssen R.   +10 more
europepmc   +1 more source