Results 281 to 290 of about 90,260 (324)

PSMD14‐Mediated LDHA Deubiquitination Upregulates ACLY Expression via H3K18 Lactylation to Promote Lipid Synthesis and Pancreatic Cancer Progression

Advanced Science, EarlyView.
This study investigates the expression and functional role of the deubiquitinase PSMD14 in PC, with a focus on the mechanism by which it promotes lactate accumulation–induced histone lactylation, thereby driving aberrant lipid metabolism. These findings establish that dual targeting of PSMD14 and the glycolysis–lactylation signaling axis may represent ...
Ri‐Shang Lu, Li‐Kun Ren, Xiao‐Bin Fei, Song‐Bai Liu, Yong‐Jia Gao, Jun‐Yi Hou, Chi Wang, Peng Liu, Chang‐Hao Zhu, Xing Wang, Yao‐Zhen Pan   +10 more
wiley   +1 more source

A nearby dark molecular cloud in the Local Bubble revealed via H₂ fluorescence. [PDF]

Nat Astron
Burkhart B, Dharmawardena TE, Bialy S, Haworth TJ, Cruz Aguirre F, Jo YS, Andersson BG, Chung H, Edelstein J, Grenier I, Hamden ET, Han W, Hoadley K, Lee MY, Min KW, Müller T, Pattle K, Peek JEG, Pleiss G, Schiminovich D, Seon KI, Wilson AG, Zucker C.   +22 more
europepmc   +1 more source

HMGB2 Promotes Cardiomyocyte Proliferation and Heart Regeneration Through MTA2‐Driven Metabolic Reprogramming

Advanced Science, EarlyView.
In contrast to the adult mammalian heart, which lacks regenerative capacity, the neonatal heart retains a transient regenerative capacity. In this study, high mobility group box 2 (HMGB2) is identified as a crucial protein driving heart regeneration based on comprehensive analyses using quantitative proteomics with tandem mass tag (TMT) labelling, RNA ...
Liu‐Hua Zhou, Ling‐Feng Gu, Yi‐Xi Chen, Peng Jing, Tong‐Tong Yang, Ye He, Yu‐Lin Bao, Xiang‐Zheng Zhang, Chong Du, Si‐Bo Wang, Tian‐Kai Shan, Jia‐Yi Chen, Hao Wang, Qi‐Ming Wang, Li‐Ping Xie, Yang Zhao, Yong Ji, Lian‐Sheng Wang   +17 more
wiley   +1 more source

Shedding new light on the context and temporality of Iberian warrior stelae: The Cañaveral de León 2 Stela and Las Capellanías burial complex (Huelva, SW Spain). [PDF]

PLoS One
García Sanjuán L, Rivera-Jiménez T, Díaz-Guardamino M, Wheatley D, Lozano Rodríguez JA, Donaire Romero T, González-García AC, Montero Artús R, Ruiz Flores J, Bermejo Meléndez J, Rogerio-Candelera MÁ, Ling J, Andrieux E, Bailiff I.   +13 more
europepmc   +1 more source

Super‐Resolution Compatible DNA Labeling Technique Reveals Chromatin Mobility and Organization Changes During Differentiation

Advanced Science, EarlyView.
A novel chromatin‐labeling probe is developed to investigate chromatin mobility during differentiation. The silicon rhodamine–conjugated dCTP is efficiently delivered into iPSCs and NSCs using a synthetic transporter. Super‐resolution microscopy and single‐particle tracking show decreased chromatin mobility during differentiation.
Maruthi K. Pabba, Miroslav Kuba, Tomáš Kraus, Kerem Celikay, Janis Meyer, Sunil Kumar Pradhan, Andreas Maiser, Hartmann Harz, Heinrich Leonhardt, Karl Rohr, Michal Hocek, M. Cristina Cardoso   +11 more
wiley   +1 more source

Control of Melt Composition and Purity for Growth of LiTbF₄ Crystals by the Bridgman Method with a Pt Crucible Sealing Technique. [PDF]

ACS Omega
Liu G, Wu H, Huang C, Yu X, Ni Y, Li Y, Qi H, Zhu Z, Hu Q, Yu P, Chen W.   +10 more
europepmc   +1 more source

Nanocatalytic Neuroprotection and Neurological Recovery Post‐Traumatic Brain Injury

Advanced Science, EarlyView.
This study demonstrates that combining Ce0.7Zr0.3O2 nanozymes with nimodipine enhances neuroprotection after traumatic brain injury. The therapy reduces oxidative stress, neuronal apoptosis, and improves blood–brain barrier integrity, with nanozymes effective at low doses.
Xinjie Hong, Liang Zhao, Xianzheng Sang, Chao Ma, Meiqi Chang, Xinran Song, Wei Feng, Tao Xu, Li Ding, Yu Chen, Lijun Hou   +10 more
wiley   +1 more source

Genome-wide association mapping and transcriptional analysis uncover genetic determinants of minor tocopherols in rice seeds. [PDF]

Sci Rep
Kazemzadeh S, Farrokhi N, Ahmadikhah A, Ingvarsson PK, Heydar KT.   +4 more
europepmc   +1 more source

Targeted Delivery of CNS‐Specific Hesperidin as a Leptin Sensitizer for Treating Obesity‐Associated Sleep‐Disordered Breathing

Advanced Science, EarlyView.
Hesperidin nanoparticles (HE NPs) effectively combat obesity and sleep‐disordered breathing in mice by enhancing leptin sensitivity. Through suppression of hypothalamic endoplasmic reticulum stress and restoration of leptin signaling, HE NPs promote weight loss and improve breathing during sleep.
Yixuan Wang, Qingyu Zhao, Qingfeng Zhang, Xiaofeng Wu, Xu Liu, Shujuan Wu, Hailing Liu, Beini Zhou, Shiqian Zha, Dong Zhao, Gang Deng, Ke Hu   +11 more
wiley   +1 more source

Targeted nanosponge-based treatment for pulmonary hypertension: A novel approach. [PDF]

J Food Drug Anal
Kaur J, Kaur G, Kaur C, Kumar S.
europepmc   +1 more source