Results 281 to 290 of about 30,171 (324)

Globular cluster formation and evolution in the context of cosmological galaxy assembly: open questions. [PDF]

Proc Math Phys Eng Sci, 2018
Forbes DA, Bastian N, Gieles M, Crain RA, Kruijssen JMD, Larsen SS, Ploeckinger S, Agertz O, Trenti M, Ferguson AMN, Pfeffer J, Gnedin OY.   +11 more
europepmc   +1 more source

LMC Calls, Milky Way Halo Answers: Disentangling the Effects of the MW--LMC Interaction on Stellar Stream Populations [PDF]

Richard A. N. Brooks, Nicolás Garavito-Camargo, Kathryn V. Johnston, Adrian M. Price-Whelan, Jason L. Sanders, Sophia Lilleengen   +5 more
openalex   +1 more source

A Single‐Molecule Pleuripotent Scaffold for Combinational Therapy of Alzheimer's Disease via Intranasal Administration

Advanced Science, EarlyView.
Herein, guanidinium‐modified calix[5]arene (GC5AY) is developed featuring small size, positive charge, and desirable amphiphilicity, that can efficiently traverse the nasal mucosal barrier for brain drug delivery. Additionally, possessing inherent therapeutic functions, GC5AY can thus serve as a single‐molecule pleuripotent scaffold for multi‐target ...
Jian‐Mei Gao, Wen‐Bo Li, Na‐Na Chen, Yang Yi, Ze‐Han Wang, Xian Chen, Yang‐Yang Zhao, Ze‐Li Yuan, Jie Gao, Yu‐Chen Pan, Dong‐Sheng Guo, Qi‐Hai Gong   +11 more
wiley   +1 more source

Inner Workings: Astronomers track dwarf galaxies to better understand the Milky Way's make-up and evolution. [PDF]

Proc Natl Acad Sci U S A, 2018
Redd NT.
europepmc   +1 more source

Punicalagin Enhances Autophagy Through Sirtuin 1/FoxO3a Axis to Inhibit Intracellular Mycobacterium Abscessus Infection

Advanced Science, EarlyView.
Punicalagin, a pomegranate molecule, helps the body fight Mycobacterium abscessus. It preferentially boosts interstitial macrophages in the lung, stabilizing mitochondria and switching on the autophagy via SIRT1/FoxO3a, which lowers bacterial load without directly killing bacteria.
Kefan Bi, Bihan Xu, Dan Cao, Kaijin Xu, Ying Zhang   +4 more
wiley   +1 more source

Enhanced Selenium Supplement Extends Lifespan and Delays Multi‐Organs Aging by Regulating the Sik1 Pathway Through Maintaining Calcium Homeostasis

Advanced Science, EarlyView.
Aging involves physiological decline and heightened disease susceptibility, necessitating effective interventions. Redox‐responsive selenium‐loaded nanoparticles (SeMSNs) are developed, which delay cellular senescence by reducing oxidative stress and senescence markers (p16/p21). In aged mice, SeMSNs extend lifespan, improve organ function, and restore
Yang Yu, Jintao Song, Mengjiao Guo, RuZe Ma, Mingyang Du, Zhe Xun, Xu Liu, RongXia Xu, Xiaochun Xie, Peilin Qi, Yujie Chen, Dan Shao, Chao Yang, Liang Wang, Xiaoyu Song, Difei Wang   +15 more
wiley   +1 more source

Novel Role of Gut‐Derived Roseburia Intestinalis in Safeguarding Intestinal Barrier Integrity and Microenvironment Homeostasis During Arsenic Exposure

Advanced Science, EarlyView.
Arsenic exposure disrupts intestinal barriers and gut microenvironment. Fecal microbiota transplantation (FMT) alleviates arsenic‐induced damage, with gut‐derived Roseburia intestinalis (R.i) identified as a key protective strain. R.i administration counters arsenic toxicity through immunomodulatory pathways and metabolites.
Lixiao Zhou, Chunsong Wang, Jieying Gao, Xu Wu, Geng Li, Xuejun Jiang, Yinyin Xia, Jun Zhang, Bo Lv, Feng Zhao, Hongyang Zhang, Huifeng Pi, Jingfu Qiu, Shangcheng Xu, Zhen Zou, Chengzhi Chen   +15 more
wiley   +1 more source

An Inflammation‐Targeting Engineered Probiotic Escherichia coli Nissle 1917 with High Anti‐TNF‐α Nanobody Secretion Efficacy Alleviates Ulcerative Colitis

Advanced Science, EarlyView.
Ulcerative colitis therapy requires precise drug targeting. This study engineers a probiotic E. coli Nissle 1917 to surface‐display ANXA5, enabling specific binding to phosphatidylserine (PS) exposed on inflamed colonic epithelium for enhanced targeting and colonization.
Siqi Hua, Kaiqiang Li, Pengyou Shang, Lina Liu, Jiayu Pan, Bo Zhu, Zichun Hua   +6 more
wiley   +1 more source

ARL5B Drives Esophageal Squamous Cell Carcinoma Progression via ROCK1–SREBP1‐Mediated Lipid Metabolic Reprogramming

Advanced Science, EarlyView.
Esophageal squamous cell carcinoma urgently requires new therapeutic strategies. Adenosine diphosphate‐ribosylation factor‐like protein 5B (ARL5B) is identified as a novel oncogene that remodels fatty acid metabolism through the ras homologous‐associated coiled‐coil containing protein kinase 1 (ROCK1)–sterol regulatory element‐binding protein 1 (SREBP1)
Xinyue Ma, Yanfei Sun, Hongyuan Mao, Chenhan Huang, Zerun Li, Tianzi Wang, Dizhi Jiang, Xinyu Zhang, Zhenyu Yuan, Zhihui Zhang, Bo Cheng, Ruiqing Wang, Yufeng Cheng   +12 more
wiley   +1 more source

Overcoming EGFR‐Mediated Dendritic Cell Dysfunction to Enhance Anti‐tumor Immunity in EGFR‐Mutant NSCLC by Precisely Targeting CD73 With pH‐responsive Nanocarriers

Advanced Science, EarlyView.
EGFR mutations drive ERK/c‐Jun–mediated transcriptional activation of CD73, elevating adenosine levels and fostering an immunosuppressive TME by impairing DC maturation and CD8⁺ T cell priming. The pH‐responsive nanodrug F127ZIF‐8AB680 selectively inhibits CD73, normalizes adenosine metabolism, and re‐establishes effective anti‐tumor immunity ...
Xiaoling Shang, Xudong Geng, Zixu Wang, Shumin Yuan, Shanshan Ding, Ni Liu, Xinchun Ma, Xuan Sun, Huimin Wang, Ying Sun, Xun Qu, Guangwen Ren, Yong Qiang Li, Xiuwen Wang, Yanguo Liu   +14 more
wiley   +1 more source