Results 291 to 300 of about 30,171 (324)

ZDHHC2‐Dependent Palmitoylation Dictates Ferroptosis and Castration Sensitivity in Prostate Cancer via Controlling ACSL4 Degradation and Lipid Peroxidation

Advanced Science, EarlyView.
Our study reveals a novel mechanism by which palmitoylation regulates ferroptosis and enzalutamide resistance in prostate cancer. Under enzalutamide resistance, the FOXA1/CXXC5/TET2 complex induces aberrant upregulation of ZDHHC2, which subsequently suppresses ferroptosis by mediating S‐palmitoylation of USP19 and degradation of ACSL4 protein in CRPC ...
Shuai Shao, Wei Li, Yulong Hong, Ruijiang Zeng, Liang Zhu, Lu Yi, Yuan Li, Yinhuai Wang, Haojie Huang, Xuewen Jiang, Xin Jin   +10 more
wiley   +1 more source

Atacama Large Aperture Submillimeter Telescope (AtLAST) science: Gas and dust in nearby galaxies. [PDF]

Open Res Eur
Liu D, Saintonge A, Bot C, Kemper F, Lopez-Rodriguez E, Smith M, Stanke T, Andreani P, Boselli A, Cicone C, Davis TA, Hagedorn B, Lasrado A, Mao A, Viti S, Booth M, Klaassen P, Mroczkowski T, Bigiel F, Chevance M, Cordiner MA, Di Mascolo L, Johnstone D, Lee M, Maccarone T, Thelen AE, van Kampen E, Wedemeyer S.   +27 more
europepmc   +1 more source

Cancer Manipulates Adjacent Adipose Tissue to Exploit Fatty Acids via HIF‐1α/CCL2/PPARα Axis: A Metabolic Circuit to Support Tumor Progression

Advanced Science, EarlyView.
Cancer cells drive adjacent adipose tissue to release fatty acids by secreting CCL2, which activates PPARα‐dependent lipolysis. The resulting fatty acid influx amplifies HIF‐1α/CCL2 signaling, establishing a positive feedback loop that fuels tumor growth.
Jeong‐Eun Yun, Jieun Seo, Jiwon Koh, Seock‐Ah Im, Ki Yong Hong, Yeseon Son, Do‐Won Jeong, Junji Fukuda, Jong‐Wan Park, Yang‐Sook Chun   +9 more
wiley   +1 more source

Gold Nanoturf‐Mediated Wireless Photothermal Upregulation of Human Adipose‐Derived Stem Cell Spheroids for Synergistic Skin‐Wound Closure

Advanced Science, EarlyView.
A wireless skin‐wound care platform for photothermal‐stem cell‐light (PTSCL) therapy, introduced here, leverages a fully wireless and battery‐free optoelectronic module, gold nanoturf‐mediated photothermal interface, and human adipose‐derived stem cell (hADSC) spheroids to synergistically enhance wound healing.
Jong Uk Kim, Jiyu Hyun, Gyan Raj Koirala, Jiwon Kim, Sung‐Won Kim, Gwang‐Bum Im, Yeong Hwan Kim, Young Gil Kim, Dong‐Hyun Lee, Hyun Su Park, Young‐Ju Jang, Young Jin Jo, Chanho Jeong, Arpan Koirala, Janghoon Joo, Sang Min Won, Suk Ho Bhang, Tae‐il Kim   +17 more
wiley   +1 more source

Cosmology and fundamental physics with the ELT-ANDES spectrograph. [PDF]

Exp Astron (Dordr)
Martins CJAP, Cooke R, Liske J, Murphy MT, Noterdaeme P, Schmidt TM, Alcaniz JS, Alves CS, Balashev S, Cristiani S, Di Marcantonio P, Génova Santos R, Gonçalves RS, González Hernández JI, Maiolino R, Marconi A, Marques CMJ, Melo E Sousa MAF, Nunes NJ, Origlia L, Péroux C, Vinzl S, Zanutta A.   +22 more
europepmc   +1 more source

Investigation into the Pancreatic Pathogenesis of SFTSV across Multiple Levels

Advanced Science, EarlyView.
A retrospective analysis revealed that 17.6% of severe fever with thrombocytopenia syndrome (SFTS) patients met the diagnostic criteria for clinically confirmed pancreatitis. Using human pancreatic organoids and murine models demonstrated that SFTSV exhibits a specific pancreatic tropism, leading to cell death and initiating a strong inflammatory ...
Xiaohan Liu, Zhihao Xu, Yilun Tong, Changtai Wang, Yueqi Yao, Yujie Diao, Jingyuan Ma, Shijun Zhou, Yinan Du, Zhenhua Zhang, Gang Xu   +10 more
wiley   +1 more source

Abundances of Neutron-capture Elements in 62 Stars in the Globular Cluster Messier 15. [PDF]

Astrophys J
Cabrera Garcia J, Sakari CM, Roederer IU, Evans DW, Silva P, Mateo M, Song YY, Kremin A, Bailey JI, Walker MG.   +9 more
europepmc   +1 more source

First resolved stellar halo kinematics of a Milky Way-mass galaxy outside the Local Group: The flat counter-rotating halo in NGC 4945

Camila Beltrand, Antonela Monachesi, Richard D’Souza, Eric F. Bell, Roelof S. de Jong, Facundo A. Gómez, Jeremy Bailin, In Sung Jang, Adam Smercina   +8 more
openalex   +1 more source

Identification of a turnover in the initial mass function of a young stellar cluster down to 0.5 MJ

De Furio M, Meyer M, Greene T, Hodapp K, Johnstone D, Leisenring J, Rieke M, Robberto M, Roellig T, Cugno G, Fiorellino E, Manara C, Raileanu R, Terwisga Sv.   +13 more
europepmc   +1 more source