Results 291 to 300 of about 29,732 (304)

Genomic Insights into the Origin, High Fecundity and Environmental Adaptation of Hu Sheep

Advanced Science, EarlyView.
The Hu sheep diverged from the Small‐tailed Han sheep ≈1330 years ago, and subsequently migrated from northern to warm and humid southern regions. The genes BMPR1B, UNC5C, and GRID2 play a synergistic role in the superior reproductive traits of Hu sheep.
Zexuan Liu, Na Zhang, Zilong Wen, Haitao Wang, Tingting Li, Runlin Ma, Menghua Li, Daxiang Wang, Haiping Shu, Xun Huang, Jianlin Han, Yiqiang Zhao, Qiuyue Liu   +12 more
wiley   +1 more source

WTAP Mediated m6A Modification Stabilizes PDIA3P1 and Promotes Tumor Progression Driven by Histone Lactylation in Esophageal Squamous Cell Carcinoma

Advanced Science, EarlyView.
This study reveals a new mechanism by which PDIA3P1 regulates the progression of esophageal squamous cell carcinoma (ESCC). PDIA3P1 upregulates the expression of GLUT1 and HK2, promoting glycolysis and lactate production. Lactate upregulates the lactylation level of histone H4K8 and activates the transcription of target gene BMP7, ultimately ...
Tao Huang, Qi You, Jiawei Liu, Xuguang Shen, Dengjun Huang, Xinlu Tao, Zhijie He, Chengwei Wu, Xinran Xi, Shouqiang Yu, Feng Liu, Zhihao Wu, Wenjun Mao, Shaojin Zhu   +13 more
wiley   +1 more source

Intermediate Filament Protein BFSP2 Controls Spindle Formation via HSC70‐Mediated Stabilization of CLTC During Oocyte meiosis

Advanced Science, EarlyView.
Meiosis is a specialized form of cell division that has different regulation and mechanisms with mitosis in numerous aspects. Particularly, meiosis I is unique and occurs only in germ cells to separate homologous chromosomes. Thus, determining how this unusual chromosome segregation behavior is established is central to understanding germ cell ...
Yu Li, Zihao Zhang, Yu Zhang, Bo Xiong
wiley   +1 more source

Modulating Macrophage–Nucleus Pulposus Cell Crosstalk via Sequential Drug Delivery Attenuates Disc Degeneration

Advanced Science, EarlyView.
The G‐CS/MSN drug delivery system enhances intervertebral disc repair through sequential drug release. Abstract Intervertebral disc degeneration (IDD) is characterized by an inflammatory environment and dysregulation of the extracellular matrix metabolism (ECM).
Xiangzhen Kong, Rui Hu, Peng Zhang, Qi Li, Kangle Song, Hanwen Gu, Jihui Zheng, Shen Liu, Liang Liu, Lin Jin, Lei Cheng, Chengwei Li, Zhijian Wei   +12 more
wiley   +1 more source

Abundances of Neutron-capture Elements in 62 Stars in the Globular Cluster Messier 15. [PDF]

Astrophys J
Cabrera Garcia J, Sakari CM, Roederer IU, Evans DW, Silva P, Mateo M, Song YY, Kremin A, Bailey JI, Walker MG.   +9 more
europepmc   +1 more source

Astrocytic ET‐1 System Determines Microglia Phenotype Following Spinal Cord Injury

Advanced Science, EarlyView.
The study reveals that astrocytic ET‐1 system is solely activated by thrombin following SCI via RhoA/NF‐κB and MAPKs/NF‐κB signal pathway. The release of astrocytic ET‐1 drives microglia polarization toward M1 phenotype through YAP signaling via ETA and ETB receptors.
Bingqiang He, Si Xu, Mengdi Li, Hui Li, Shaolan Li, Li Niu, Honghua Song, Rixin Cai, Yue Zhou, Zhilong Cao, Yingjie Wang, Yongjun Wang   +11 more
wiley   +1 more source

Identification of a turnover in the initial mass function of a young stellar cluster down to 0.5 MJ

De Furio M, Meyer M, Greene T, Hodapp K, Johnstone D, Leisenring J, Rieke M, Robberto M, Roellig T, Cugno G, Fiorellino E, Manara C, Raileanu R, Terwisga Sv.   +13 more
europepmc   +1 more source

Feedback mechanisms stopping the star formation in a pair of massive galaxies in the early Universe

Pérez-González P, D'Eugenio F, Pino BRD, Perna M, Uebler H, Maiolino R, Arribas S, Lamperti I, Bunker A, Carniani S, Charlot S, Willott C, Böker T, Parlanti E, Scholtz J, Venturi G, Barro G, Costantin L, Navarro IM, Dunlop J, Magee D, Cresci G.   +21 more
europepmc   +1 more source

Primordial Rotating Disk Composed of ≥15 Star Forming Clumps at Cosmic Dawn

Fujimoto S, Ouchi M, Kohno K, Valentino F, Giménez-Arteaga C, Brammer G, Furtak L, Kohandel M, Oguri M, Pallottini A, Richard J, Zitrin A, Bauer F, Boylan-Kolchin M, Dessauges-Zavadsky M, Egami E, Finkelstein S, Ma Z, Smail I, Watson D, Hutchison T, Rigby J, Welch B, Ao Y, Bradley L, Caminha G, Caputi K, Espada D, Endsley R, Fudamoto Y, González-López J, Hatsukade B, Koekemoer A, Kokorev V, Laporte N, Lee M, Magdis G, Ono Y, Rizzo F, Shibuya T, Shimasaku K, Sun F, Toft S, Umehata H, Wang T, Yajima H.   +45 more
europepmc   +1 more source

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Stellar Populations of the Outer Milky-Way Halo

Proceedings of the International Astronomical Union, 2017
AbstractThe stellar spheroidal components of the Milky-Way contain the oldest and most metal poor of its stars. Inevitably the processes governing the early stages of Galaxy evolution are imprinted upon them. According to the currently favoured hierarchical bottom-up scenario of galaxy formation, these components, specially the Galactic halo, are the ...
Anna B. A. Queiroz, Baslio Santiago, Elmer Luque, Adriano Pieres   +3 more
openaire   +2 more sources