Results 241 to 250 of about 100,839 (288)
Direct Selection of Functional De Novo Macrocycles for Activation of On‐Cellulo Insulin Receptor
Angewandte Chemie, EarlyView.A live‐cell screening platform, RaPID‐ExCells, integrates mRNA display‐derived macrocyclic peptide libraries with functional selection against native cell‐surface receptors. Application to the insulin receptor enabled de novo discovery of a macrocyclic agonist that activates endogenous signaling despite weak in vitro binding, highlighting the power of ...
Yun‐Hsuan Kuo +3 more
wiley +1 more source
Structural Mechanism of an Efficacy Photoswitch Targeting the β2‐adrenergic Receptor
Angewandte Chemie International Edition, EarlyView.Time‐resolved structures from x‐ray free‐electron laser measurements combined with cellular assays demonstrate how the photoswitchable β‐blocker photoazolol‐1 acts as an efficacy switch of β2‐adrenergic receptor function. Light‐induced ligand repositioning shifts activity from inverse agonism toward neutral antagonism by altering local helical ...
Robin Stipp +29 more
wiley +1 more source
Command Performances: Black Storytellers In Ruth McEnery Stuart\u27s Blink (1893) And Charles W. Chesnutt\u27s The Dumb Witness (1899) [PDF]
, 2002 Schmidt, Peter
core +1 more source
Interventions Through Music and Interpersonal Synchrony That Enhance Prosocial Behavior: A Systematic Review. [PDF]
Eur J Investig Health Psychol EducPardo-Olmos M +3 more
europepmc +1 more source
Art psychotherapy meets creative AI: an integrative review positioning the role of creative AI in art therapy process. [PDF]
Front PsycholZubala A +3 more
europepmc +1 more source
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