Results 91 to 100 of about 54,740 (209)

Intravenous Lipopolysaccharide Challenge in Healthy Participants Reveals Pharmacodynamic Markers in Blood and Bone Marrow for Early‐Phase Oncology Drug Development

Clinical Pharmacology &Therapeutics, EarlyView.
Demonstrating pharmacological effects in early‐phase oncology clinical trials remains challenging, largely due to the lack of robust pharmacodynamic markers. Lipopolysaccharide (LPS) is used as an immune challenge agent in healthy participants to study drugs for autoimmune conditions.
Igor Radanović, Ingrid Tomljanović, Wieke H. Grievink, Diana R. Pereira, Michelle Osse, Peter van Balen, Maria J. Juachon, Marieke L. de Kam, Lisa Pagan, Manon A.A. Jansen, Matthijs Moerland, Jacobus J. Bosch   +11 more
wiley   +1 more source

Insights and Future Directions on the Combined Effects of Mind-Body Therapies with Transcranial Direct Current Stimulation: An Evidence-based Review. [PDF]

J Int Soc Phys Rehabil Med, 2022
Rebello-Sanchez I, Vasquez-Avila K, Parente J, Pacheco-Barrios K, De Melo PS, Teixeira PEP, Jong K, Caumo W, Fregni F.   +8 more
europepmc   +1 more source

Identification of a Functional CYP2C8 Variant Allele that Alters Splicing, Reduces Protein Expression, and Increases Drug Exposure

Clinical Pharmacology &Therapeutics, EarlyView.
This study investigated genetic determinants of the pharmacokinetics of the CYP2C8 index drugs repaglinide and gemfibrozil, and their interaction in healthy participants. Sequencing data from a study with montelukast revealed a novel functional CYP2C8 allele (rs2071426, CYP2C8*19), predicted to create an intronic splice donor site.
Anssi J. H. Mykkänen, Päivi Hirvensalo, Kathrin Klein, Dorota Kaminska, Markus Grube, Tuija Tapaninen, Johanna I. Kiiski, Mikko Neuvonen, Ville T. Männistö, Jussi Pihlajamäki, Mladen Tzvetkov, Matthias Schwab, Aleksi Tornio, Janne T. Backman, Mikko Niemi   +14 more
wiley   +1 more source

Are mind-body therapies effective for relieving cancer-related pain in adults? A systematic review and meta-analysis. [PDF]

Psychooncology, 2022
Danon N, Al-Gobari M, Burnand B, Rodondi PY.   +3 more
europepmc   +1 more source

“Efforts to Surface the Unspoken”: A Mixed Methods Study of a Risk‐Informed Check‐In in Norwegian Family Mediation

Conflict Resolution Quarterly, EarlyView.
ABSTRACT In family mediation, emotional discomfort and perceived unsafety may signal deeper relational risks, including postseparation violence. Standard intake procedures in Norwegian family mediation depend on disclosure to a nonclinical administrator before any therapeutic relationship exists, and research documents systematic under‐reporting at ...
Jan Stokkebekk, Trine Eikrem, Kristoffer Whittaker   +2 more
wiley   +1 more source

Health and quality of life promotion for old people using bodily practices

O Mundo da Saúde, 2014
The increasing of the elderly population is related to better material conditions for survival and progress of health practices. Bodily practices are recognized as an important strategy for health promotion and disease prevention for this population ...
Rosé Colom Toldrá, Renata Guimarães Cordone, Bruna de Almeida Arruda, Ana Cristina Fagundes Souto   +3 more
doaj  

Optimal doses of mind-body exercise on neuroinflammation in individuals with neuropsychiatric disorders: A systematic review and dose-response meta-analysis

Brain, Behavior, & Immunity - Health
Background: Mind-body exercises (MBEs), including Tai Chi (TC), Qigong (QG), Yoga (YG), and Mindfulness-Based Stress Reduction (MBSR), show promise in neuropsychiatric rehabilitation by modulating neuroinflammation. This study systematically examines the
Qingying Zheng, Guoyuan Huang, Qian Liu, Weiguang Ni, Ying Zhao   +4 more
doaj   +1 more source

Precision Medicine for Breath-Focused Mind-Body Therapies for Stress and Anxiety: Are We Ready Yet? [PDF]

Glob Adv Health Med, 2021
Lavretsky H, Feldman PhD JL.
europepmc   +1 more source

Associations Between Self and Peer's Fear of Fat in Predicting Dietary Restraint, Weight/Shape/Eating Concerns, and Thin‐Ideal Internalization: A Dyadic Exploration in Female Friend Pairs

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective Fear of fat may reflect concern regarding rejection one may experience at a higher weight. Peers play a major role in socialization and support during adolescence and young adulthood. While studies have highlighted peers as an important source of influence underlying disordered eating, it is unclear whether one's own fear of fat or ...
Shannon M. O'Connor, Caroline G. Martin, Leora L. Haller, Shannon Marhan   +3 more
wiley   +1 more source

Brief preoperative mind-body therapies for total joint arthroplasty patients: a randomized controlled trial. [PDF]

Pain, 2021
Hanley AW, Gililland J, Erickson J, Pelt C, Peters C, Rojas J, Garland EL.   +6 more
europepmc   +1 more source