Results 141 to 150 of about 25,335,002 (250)

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

FEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang, Mingqiang Deng, Dongmei He, Diqin Lai, Dongjun Liu, Dengyong Zhu, Zhenhua Zhang, Peng Tang, Chuanman Zhou, Menghui Yin, Xichen Bao   +10 more
wiley   +1 more source

Robots in mine search and rescue operations: a review of platforms and design requirements. [PDF]

Front Robot AI
Bakzadeh R, Androulakis V, Khaniani H, Shao S, Hassanalian M, Roghanchi P.   +5 more
europepmc   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

Self-Powered Z-Shaped Hybrid Triboelectric-Electromagnetic Vibration Sensor for Coal Mine Fracturing Condition Monitoring. [PDF]

Micromachines (Basel)
Miao Y, Liu D, Zuo Z, Feng Y, Wu C.
europepmc   +1 more source

Optimizing photoexcitation conditions for time‐resolved X‐ray solution scattering experiments

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering (TR‐XSS) is a powerful technique to visualize how proteins change their structure in real time after light activation. Selecting the right laser photoexcitation conditions—fluence, excitation geometry, and sample refresh rate—is critical to maximize the experimental signal while avoiding unwanted side effects ...
Matteo Levantino
wiley   +1 more source

Growing nickel supply from the tropics threatens priority conservation areas. [PDF]

Nat Ecol Evol
Hyman J, Sonter LJ, McDonald-Madden E, Watson JEM, Mervine EM, Bull JW, Dawson C, Lloyd TJ, Luckeneder S, Maron M, Mendonca Severiano B, Raymond S, Schlacher TA, Sreekar R, Valenta RK, Visconti P, Werner TT, Northey SA.   +17 more
europepmc   +1 more source

Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA

FEBS Open Bio, EarlyView.
Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley   +1 more source

Fault-induced detection method for power supply lines in the cutting unit of coal shearer based on PIO-VMD-EDO. [PDF]

Sci Rep
Wang Y, Rong X, Shi H, Liu M, Guo X, Cheng Z, Wang W.   +6 more
europepmc   +1 more source

Identification of (20R)‐protopanaxadiol from Panax ginseng as a novel anti‐SARS‐CoV‐2 compound

FEBS Open Bio, EarlyView.
We established a noninfectious BAC‐based SARS‐CoV‐2 replicon that enables antiviral screening under BSL‐2 conditions. Using this platform, we screened 373 food‐derived compounds and identified (20R)‐protopanaxadiol from Panax ginseng as a novel inhibitor of SARS‐CoV‐2 RNA replication, highlighting the value of safe replicon systems for antiviral ...
Midori Takeda, Natsue Maezono, Rina Uchikoshi, Nobuyuki Kato, Masanori Ikeda   +4 more
wiley   +1 more source

Pathways to cost competitive and viable lithium production from Salton Sea geothermal brines. [PDF]

Nat Commun
Wesselkaemper J, Renaud T, Araya N, Dekkers K, Popineau J, Riffault J, O'Sullivan J, Haddad AZ.   +7 more
europepmc   +1 more source