Results 81 to 90 of about 26,900,272 (247)

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Renovation and Optimization of Operation Mode of Dual-circuit Power Supply System in Coal Mine

, 2011
For the problem that most dual-circuit power supply systems in coal mine underground could not accord with requirements of version 2009 of Coal Mine Safety Regulations, the paper presented a way of renovation and optimization of operation mode of dual ...
LI Fu
core  

Power Company Fuel Supply - Problems And Solutions

, 1982
A power company in the business of supplying electricity to its customers faces numerous problems associated with power production. One of its major problems is to supply its power plants with fuel and to use that fuel as economically as possible.
Smith, R. A., Morgan, J. Derald
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Influence of structure and ownership of lignite opencast mine and power plant bilateral monopoly on its operation [PDF]

Lignite mine and power plant can operate as two separate entities, two entities in one holding or joint venture and as the one vertically integrated energy producer.
Jurdziak, Leszek
core  

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Research and application of remote intelligent fluid supply and power supply technology in coal mine super-long strike fully mechanized caving face

Meitan kexue jishu
In the working conditions of long-strike coal mine faces, the traditional approach for liquid supply and power supply equipment is mobile withdrawal to follow the mining progress. However, this production method has several drawbacks. It involves a large
Chuanming ZHANG, Qingkai ZANG, Yongming NIU, Hui GUO, Ran LI, Dongyue ZHANG   +5 more
doaj   +1 more source

Research of comprehensive quantitative evaluation of power quality of coal mine

Gong-kuang zidonghua, 2015
The current harmonic distortion reflecting the maximum load current was defined, and a distortion power factor considering non-sinusoidal current waveform was built according to special requirements of coal mine electrical load.
WANG Qingliang, YAO Miao
doaj   +1 more source