Results 31 to 40 of about 1,938 (249)

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Simulation Of Mine Water Inflow: Case Study Of The Štavalj Coal Mine (Southwestern Serbia)

Archives of Mining Sciences, 2015
Abstract The inflow of mine water to mining operations is often caused by random events such as precipitation. Consequently, the mine water inflow regime can be defined as a function of random events applying the theory of random processes. Regression models of the multiple linear correlation type have been used to simulate the inflow of mine water ...
Branko Miladinović, Vesna Ristić Vakanjac, Dragomir Bukumirović, Veselin Dragišić, Boris Vakanjac   +4 more
openaire   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Risk Assessment of Coal Roof Water Inrush Based on Water-rich Index

Meikuang Anquan, 2020
This paper is aimed at the evaluation of the risk of water gushing in the middle and lower Jurassic aquifers in the coal roof of Tarangaole Coal Mine, the weight values of the water-rich influencing factors such as aquifer thickness, collecting rate of ...
HUANG Huan, ZHU Hongjun
doaj   +1 more source

Optimal control of mine multi-level relay drainage system

Gong-kuang zidonghua, 2020
The electricity consumption of mine multi-level relay drainage system is very large, in order to improve economy of drainage system operation, it is necessary to optimize drainage system control, but current optimal control methods of mine multi-level ...
HAN Xiuqi
doaj   +1 more source

Derivative mine dynamic water inrush mode of skylight leakage and its evaluation and control technology system

Meitan xuebao, 2023
The central and western coal resources have the highest degree of enrichment and superior development conditions in China. With the improvement of mining efficiency, the disturbance of high-intensity and large-mining-height mining mode to groundwater ...
Yifan ZENG, Shihao MENG, Qiang WU, Zhenzhong PANG, Kai PANG, Guoqing YANG, Aoshuang MEI, Qiang LI, Sitong WANG   +8 more
doaj   +1 more source

Emerging insights into CC and CXC chemokines and their receptors in Mycobacterium tuberculosis infection

FEBS Open Bio, EarlyView.
The dual roles of CC and CXC chemokines in distinguishing active, latent, and subclinical tuberculosis were reviewed, along with an evaluation of their potential as diagnostic biomarkers and therapeutic targets to advance precision medicine in tuberculosis management. The graphical abstract was generated with AI assistance (Gemini 3.0).
Xuying Yin, Dangsheng Xiao, Jiezuan Yang
wiley   +1 more source

Construction and application of a TCN-LSTM-SVM-based time series prediction model for water inflow in coal seam roofs

Meitian dizhi yu kantan
BackgroundThe accurate prediction of mine water inflow plays a significant role in the prevention and control of water hazards and the safe and efficient production in coal mines.
Xuan LIU, Yadong JI, Kaipeng ZHU, Chunhu ZHAO, Kai LI, Chaofeng LI, Chenhan YUAN, Panpan LI, Pengzhen YAN   +8 more
doaj   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source