Results 51 to 60 of about 860,594 (296)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Optimization design of mine regional ventilation system

Gong-kuang zidonghua, 2021
Most of the existing ventilation system optimization designs focus on general mine ventilation systems, and there are few optimization designs for regional mine ventilation systems.
LIU Kunlun1, HAN Yaozhong2, QIN Cunli3, WANG Gang4   +3 more
doaj   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Calculation model for ventilation friction resistance coefficient by surrounding rock roughness distribution characteristics of mine tunnel

Scientific Reports, 2022
Real-time mine ventilation network solution is the core way to realize the actual intelligent ventilation, and ventilation friction resistance coefficient is a significant parameter of network solution. With the help of fractal theory to characterize the
Ke Gao, Zhipeng Qi, Yujiao Liu, Jinyi Zhang   +3 more
semanticscholar   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

MINE VENTILATION EXPERT SYSTEM

Applied Artificial Intelligence, 1988
A growing trend in the area of artificial intelligence is the development of software that simulates the decision-making process of human experts. The purpose of this paper is to advance the use of available tools from the area of artificial intelligence, and in particular expert systems, into the field of mine ventilation management.
TOM ALTMAN, TOM HUGHES, ANDRZEJ WALA
openaire   +1 more source

Experimental and numerical simulation study on forced ventilation and dust removal of coal mine heading surface

International Journal of Coal Science & Technology
In order to study the problems of unreasonable airflow distribution and serious dust pollution in a heading surface, an experimental platform for forced ventilation and dust removal was built based on the similar principles.
Haotian Zheng, Bingyou Jiang, Haoyu Wang, Yuannan Zheng   +3 more
semanticscholar   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Head-neck local ventilation mode for long-narrow mine working face

Scientific Reports
To improve the thermal health state of workers in mines facing heat hazards and enhance cooling capacity utilization efficiency of mine ventilation, this study proposes a suitable air distribution for mine workers’ local cooling, taking into account the ...
Jue Wang, Cheng Jiang, Xihua Zhou, Jiayu Kang, Shixuan Yu, Gang Bai   +5 more
semanticscholar   +1 more source

Screening of Evaluation Index and Construction of Evaluation Index System for Mine Ventilation System

Sustainability, 2021
The mine ventilation system is an indispensable component to improve coal mining efficiency and ensure the safety of production. Only by clearly grasping the comprehensive evaluation quality of the ventilation system can effective countermeasures be ...
Qiu-Ping Bi, Yu-Cheng Li, Cheng-Hung Shen   +2 more
semanticscholar   +1 more source