Results 41 to 50 of about 5,070,469 (292)
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Environ 2.5 — A Mine Ventilation and Cooling Network Simulation Tool [PDF]
, 1999 As mining operations progress, ore reserves are depleted and alternative are almost invariably found at increasing depth and a host of attendant difficulties in this regard face· the mine operator.
Marx, W. M.
core +1 more source
IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo
FEBS Open Bio, EarlyView.To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley +1 more source
Architecture and key technologies of intelligent mine ventilation system
Gong-kuang zidonghuaExisting studies on intelligent mine ventilation still show deficiencies in accurate perception of key parameters, coupled processing of multi-source information, and coordinated regulation, and have not yet formed an integrated technical system, which ...
XU Xuezhan, ZOU Yunlong
doaj +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Digital technologies hold promise for transforming healthcare by enhancing personalized treatments and offer valuable opportunities to improve patient care. Here, we evaluated several novel, self‐administered, home‐based, digital endpoints for their association with corresponding conventional standard clinical measures (primary) in ...
Arne Mueller +14 more
wiley +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To clarify the clinical relevance of dopamine transporter single‐photon emission computed tomography (DAT‐SPECT) abnormalities in amyotrophic lateral sclerosis (ALS), with a prespecified focus on sex‐stratified associations with disease progression and short‐term prognosis.
Tomoya Kawazoe +7 more
wiley +1 more source
Analysis of a ventilation network in a multiple fans limestone mine [PDF]
, 2014 As mining progresses the total resistance of an excavation is increased, the mine characteristic curve becomes steeper, and the operating point moves up the fan curve, reducing the total air quantity and increasing the system pressure.
Haghighat, Ali
core +1 more source
Onasemnogene Abeparvovec in Patients With SMA: Interim Results of the RESTORE Registry in Japan
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective There are limited real‐world data regarding the safety and effectiveness of onasemnogene abeparvovec (OA; Zolgensma) infusion, a one‐time gene replacement therapy, for Japanese patients with spinal muscular atrophy (SMA). We aimed to improve understanding of the real‐world outcomes for OA in Japan.
Kayoko Saito +8 more
wiley +1 more source
Applied SciencesIn ventilation systems of metal mines, the real-time measurement of the airflow field and a reduction in pollutants are necessary for clean environmental management and human health.
Yin Chen +6 more
doaj +1 more source
Research on intelligent control system of “one ventilation and three prevention” in coal mines
Meikuang Anquan, 2022 In view of the difficulty of professional management of “one ventilation and three prevention” to meet the demand of daily intelligent control of mine, the paper proposes to build an intelligent control system for one ventilation and three prevention in
WANG Zhenping +4 more
doaj +1 more source