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ABSTRACT Objective This analysis evaluates the effect of successful reperfusion on functional outcomes after MT, stratified by admission National Institutes of Health Stroke Scale (NIHSS) and Alberta Stroke Program Early CT Score (ASPECTS) as surrogates for clinical‐core mismatch, using multicenter registry data.
Felix Schlicht +53 more
wiley +1 more source
A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema
ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling +16 more
wiley +1 more source
ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan +9 more
wiley +1 more source
Potato (Solanum tuberosum L.) cultivars physiological, biochemical performance and yield parameters response to acid mine water irrigation and soil physiochemical properties. [PDF]
Munyai R, Modise DM.
europepmc +1 more source
Well water contaminated by acidic mine water from the Dabaoshan Mine, South China: Chemistry and toxicity [PDF]
An investigation into well water quality was carried out in a rural area subject to irrigation with acidic mine water from the Guangdong Dabaoshan Mine, southern China.
Lizhong Zhu
exaly +2 more sources
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Sustainability Mining: Water for Mining, and Mining Water
2014This chapter examines the multifaceted nature of the relationship between water and mining. Several perspectives are offered. Mines are located to gain access to the mineral, but this is always in the context of water. The conditions under which the water has carved a catchment are strongly influenced by the climatic regime and the geological ...
Gemma Broderick, Pierre Horwitz
openaire +1 more source
2013
Caused by the oxidative dissolution of sulfide minerals, mine waters are often acidic and contaminated with high concentrations of sulfates, metals, and metalloids. Because the so-called acid mine drainage (AMD) affects the environment or poses severe problems for later use, treatment of these waters is required.
Robert, Klein +3 more
openaire +2 more sources
Caused by the oxidative dissolution of sulfide minerals, mine waters are often acidic and contaminated with high concentrations of sulfates, metals, and metalloids. Because the so-called acid mine drainage (AMD) affects the environment or poses severe problems for later use, treatment of these waters is required.
Robert, Klein +3 more
openaire +2 more sources

