Results 111 to 120 of about 2,538,610 (251)

Effects of Therapeutic Exercise on Bone Health and Mineral Metabolism in Chronic Kidney Disease–Mineral and Bone Disorder: A Systematic Review and Meta-Analysis

Physiologia
Background/Objectives: Chronic Kidney Disease–Mineral and Bone Disorder (CKD-MBD) is a frequent complication of chronic kidney disease, characterized by altered bone mineral density and mineral–hormonal metabolism. Therapeutic exercise may help attenuate
Jiawei Andre Guo Liang, Rafael Jiménez Lopez, Carmen Cruz Herrera, Alejandro Heredia Ciuró, Valentina Beron Quilindo, Jesús Zamora Tortosa, Marie Carmen Valenza   +6 more
doaj   +1 more source

Inositol 1,4,5-trisphosphate receptor type 2 is associated with the bone-vessel axis in chronic kidney disease-mineral bone disorder. [PDF]

Ren Fail, 2023
Xiao Q, Tang Y, Luo H, Chen S, Tang Q, Chen R, Xiong L, Xiao J, Hong D, Wang L, Li G, Li Y.   +11 more
europepmc   +1 more source

Age‐Related Lamin B1 Deficiency Activates SLC7A11‐Dependent Disulfidptosis to Impair Osteogenesis via Intercepting Mitochondrial Fission

Advanced Science, EarlyView.
This study reveals that age‐related LMNB1 deficiency in mesenchymal stem cells epigenetically upregulates SLC7A11, triggering actin disulfidptosis and mitochondrial dysfunction. This cascade impairs bone formation in senile osteoporosis. Furthermore, researchers identified the FDA‐approved drug naldemedine as a targeted SLC7A11 inhibitor to reverse ...
Wenhui Yu, Qibo Li, Weihao Zhang, Guan Zheng, Junhua Chen, Yipeng Zeng, Zipeng Xiao, Zibin Chen, Ziqian Liu, Yangfeng Lin, Jiajie Lin, Zepeng Su, Zhongyu Xie   +12 more
wiley   +1 more source

Antihypertensive treatment with hydrochlorothiazide-hydralazine combination aggravates medial vascular calcification in CKD rats with mineral bone disorder. [PDF]

Front Cardiovasc Med, 2023
Larivière R, Ung RV, Picard S, Richard DE, Mac-Way F, Agharazii M.   +5 more
europepmc   +1 more source

A Novel Reactive Oxygen Species‐Responsive Bone‐Targeted Nanoplatform Based on Cloperastine Attenuates Ovariectomy‐Induced Bone Loss by Inhibiting Osteoclast Oxidative Phosphorylation

Advanced Science, EarlyView.
Cloperastine suppresses osteoclastogenesis by inhibiting PGC1β‐mediated oxidative phosphorylation. Its incorporation into a ROS‐responsive, Asp8‐modified nanoplatform enhances skeletal accumulation. The resulting Clo/Asp8‐PMK‐MCs combine cloperastine‐mediated antiresorptive activity with carrier‐mediated osteogenic activity to attenuate OVX‐induced ...
Haibo Liang, Yong Xiao, Jiangtao Luo, Xiao Yang, Yayun Yang, Qihang Wu, Chenxin Yu, Zhihao Zhou, Xiaoqing Si, Jiansen Miao, Yiting Tu, Qichen Lu, Boreng Qian, Xiangyang Wang, Jiake Xu, Changcan Shi, Haiming Jin   +16 more
wiley   +1 more source

Bone mineral loss damages renal tubules in mice

Communications Biology
Fibroblast growth factor-23 (FGF23) is a bone-derived hormone that promotes urinary phosphate excretion in response to phosphate loading. While essential for phosphate homeostasis, elevated FGF23 increases phosphate concentration in the renal tubular ...
Hirosaka Hayashi, Yutaka Miura, Yoshitaka Iwazu, Hideyuki Mukai, Yoshiyuki Mori, Takahiro Kuchimaru, Nobuhiko Ohno, Tatsuya Aiba, Risa Okada, Daisuke Kamimura, Dai Shiba, Hiroshi Kurosu, Makoto Kuro-o   +12 more
doaj   +1 more source

A Novel NR3C1 Frameshift Variant Associated With Familial Glucocorticoid Resistance Syndrome: An Integrated Analysis of Steroid Profiling and Structural Modeling

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Glucocorticoid resistance syndrome (GRS) is a rare hereditary disorder caused by pathogenic variants in NR3C1, characterized by marked phenotypic heterogeneity and frequent misdiagnosis as primary aldosteronism or subclinical Cushing's syndrome.
Sufang Yun, Zhifeng Zhu, Fengye Zhou, Ying Liu, Chunfang Liang, Haitao Ju, Lin Lu, Zhaoli Yan   +7 more
wiley   +1 more source

Serum TRACP-5b as a Marker for Bone Turnover in Chronic Kidney Disease: Correlation with Mineral-Bone Disorder Markers

JK Science
Background: Chronic Kidney Disease-Mineral and Bone Disorder (CKD-MBD) leads to progressive alterations in bone turnover and mineral metabolism. Tartrate-resistant acid phosphatase 5b (TRACP-5b) is a promising biomarker for bone resorption, potentially ...
Lohitha Polisetty, B R Neeharika, Smriti Sinha   +2 more
doaj  

Effects of selenium and iodine on Kashin-Beck disease: an updated review

Frontiers in Nutrition
Kashin-Beck disease (KBD) is an endochondral osteogenesis disorder characterised by epiphysis damage and secondary deformable arthropathy induced by multiple external factors, among which selenium (Se) and iodine deficiency are important influencing ...
Lin Liu, Pan Luo, Pengfei Wen, Peng Xu
doaj   +1 more source

Spinal Involvement in Charge Syndrome: Implications for Management

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT CHARGE syndrome (OMIM #214800) is an autosomal dominant disorder caused by mutations in the CHD7 gene in most cases. Although originally defined by the CHARGE acronym (coloboma, heart defects, choanal atresia, growth restriction, genital hypoplasia, and ear anomalies), the recognized phenotype has expanded considerably to include highly ...
Adriana Gomes, Álvaro Martín‐Rodríguez, Miguel del Campo Casanelles, Marilyn C. Jones, Daniela Carvalho, Lynne M. Bird   +5 more
wiley   +1 more source