Results 161 to 170 of about 6,708,478 (287)

An Injectable Metal‐Drug Supramolecular Condensate Enables Radiosensitization and Systemic Antitumor Immunity for Post‐Surgical Osteosarcoma Therapy

Advanced Science, EarlyView.
This work designed an injectable metal‐drug supramolecular condensate formed from hafnium ions and alendronate (Hf‐ALN) and loaded with the COX‐2 inhibitor celecoxib (CXB) for synergistic radioimmunotherapy of postoperative osteosarcoma. Mechanistically, upon X‐ray irradiation, Hf enhances radiation energy deposition, ROS generation, and DNA damage ...
Tianhua Xiao, Zunlei Gong, Chuke Chen, Hui Yu, Yu Cai, Can Liu, Hongkai Huang, Ying Li, Jinyuan Guan, Le Wang, Chengyun Ning, Guoxin Tan, Lei Zhou   +12 more
wiley   +1 more source

Fault-controlled natural hydrogen reservoirs as underground hydrogen storage sites. [PDF]

Proc Natl Acad Sci U S A
Hou L, Zhang Z, Elsworth D, Zhang F, Perera S, Lei Q, An M, Zhang L, Zhou Q.   +8 more
europepmc   +1 more source

The Evolution of Machine Learning in Large-Scale Mineral Prospectivity Prediction: A Decade of Innovation (2016–2025)

The continuous growth in global demand for mineral resources and the increasing difficulty of mineral exploration have created bottlenecks for traditional mineral prediction methods in handling complex geological information and large amounts of data ...
Fanchao Zhou, Xiaofei Xu, Quantong Zhou, Xiao Li, Zekang Fu, Xiaojun Zheng, Yongfeng Yan, Weikun Mai   +7 more
core   +1 more source

Bone Marrow Macrophage STING Signaling is a Direct Nexus Linking Marrow Adipose Expansion to NAD+ Depletion and Osteogenic Decline in Skeletal Aging

Advanced Science, EarlyView.
This study reveals that during skeletal aging, bone marrow adipocyte‐derived sDPP4 primes STING signaling in macrophages. In combination with mitochondrial DNA, this signaling activates CD38 and depletes local NAD+/NMN, thereby impairing osteogenesis.
Zhichao Li, Kuanhui Gao, Mengjie Wang, Songlin Liang, Dandan Li, Guoqing Tan, Haipeng Xue, Yujie Liu, Peng Zhang, Zhanwang Xu, Wenxiang Cheng, Yongjun Wang, Nianhu Li   +12 more
wiley   +1 more source

Rapid consumption of H₂ in the deep subsurface. [PDF]

Natl Sci Rev
Xie H, Xu T, Wang X, He K, Peng Y, Yang C, Tong F, Han S, Eiler JM, Bao H.   +9 more
europepmc   +1 more source

Category 5 Exploration Licence Polygons of Tasmania (Mineral Resources Tasmania

Maintenance and Update Frequency: asNeededCategory 5 Exploration Licence polygons and Exploration Release Areas across Tasmania, with tenement information derived from the Tasmanian Information on Geoscience and Exploration Resources (TIGER) system ...

core  

TGFBI Maintains Fibrocartilage Homeostasis by Restraining O‐GlcNAcylation to Inactivate and Destabilize ADAMTS16 in Temporomandibular Joint Osteoarthritis

Advanced Science, EarlyView.
TGFBI deficiency elevates O‐GlcNAcylation, promoting the transcriptional activation of ADAMTS16 and OGT‐mediated post‐translational modification of ADAMTS16 at Ser1170. This leads to its stabilization and accumulation, driving chondrocyte metabolic disorders and senescent phenotypes, ultimately resulting in fibrocartilage dysfunction and TMJOA ...
Xin Liu, Xinyue Luo, Jie Zhao, Ziyan Jiang, Jiayi Zhai, Taomin Zhu, Xueke Jia, Xiaohan Ma, Henghua Jiang, Huimin Li, Yaping Feng, Jin Ke, Xing Long   +12 more
wiley   +1 more source

Ultrasonic and Resistivity Sensor Fusion for Discriminating Gas Injection Rates. [PDF]

Sensors (Basel)
Wang J, Li X, Tang G, Yao Y, Wang Q, Li W, Luo M.   +6 more
europepmc   +1 more source

Phase Separation of SF3B1 Serves as a Critical Post‐Transcriptional Regulator During Early Mouse Embryogenesis

Advanced Science, EarlyView.
Phase separation of SF3B1 acts as a key regulatory mechanism for dynamic alternative splicing throughout early mouse embryogenesis. Its absence triggers extensive splicing errors, which induce persistent DNA damage, defective cell cycle progression, and failed cell lineage commitment, and ultimately hinder the normal growth and development of ...
Kang Zhao, Ting‐Yu Han, Yan‐Li Cheng, Yi‐Dan Zhang, Yu‐Wei Zhang, JinJian Guo, ShaoJun Zhang, WenZe Huang, Jing Zhang, Pei‐Yu Liao, Ying Xin, ChuanChen Chu, Qing‐Yuan Sun, ZhiZhen Liu, Xiang‐Hong Ou, Jun Xie   +15 more
wiley   +1 more source

Moon Insight: a conceptual framework for future lunar exploration. [PDF]

Natl Sci Rev
Liu Y, Zou Y, Wang C.
europepmc   +1 more source