Results 181 to 190 of about 3,414 (266)

FOS3D: A Fluorescence‐Enabled Toolkit for Characterizing a Three‐dimensional Osteosarcoma Model

open access: yesAdvanced Science, EarlyView.
FOS3D describes fluorescent (F) osteosarcoma (OS) cells in a tri‐dimensional (3D) model. The study comprises three phases: development, where biofabrication parameters are tuned to achieve cytocompatibility and tumor‐specific mechanical properties in cell‐laden gelatin methacryloyl constructs; validation, where whole‐well fluorescence reading is ...
William Humble   +9 more
wiley   +1 more source

Micro‐Galvanic Coupling Programs the Therapeutic Zinc Ion Window to Reconfigure Immune Cascades for Pro‐Regenerative Bone Healing

open access: yesAdvanced Science, EarlyView.
This study utilized alloy micro‐galvanic coupling design to regulate the release of essential elements, thereby programming immune responses and promoting regeneration. The sacrificial anodic process of Zn‐0.8Mg reduced Zn2+ release compared to the “large cathode‐small anode” coupling of Zn‐0.8Fe.
Chaoyang Sun   +14 more
wiley   +1 more source

Spin‐Selective Oxygen Evolution in Chiral Molecule‐Intercalated Layered Double Hydroxides

open access: yesAdvanced Science, EarlyView.
This hybrid electrocatalyst utilizes chiral phenylalanine intercalation within layered double hydroxides to boost oxygen evolution. Acting as a spin filter via the chiral‐induced spin selectivity effect, the material directs electron transfer along a lower‐energy pathway.
Chih‐Ying Huang   +17 more
wiley   +1 more source

Efficient Concentration and Complete Destruction of Short‐Chain and Emerging PFAS in Contaminated Water via Integrated Interface Engineering‐Enhanced Carbon Felt Sorption and Photochemical Processes

open access: yesAdvanced Science, EarlyView.
A closed‐loop “Concentrate‐Destroy” strategy is presented for completely eliminating short‐chain and emerging PFAS, in which the new 3D PPy@P‐CF is used for efficiently concentrating PFAS and Cu2+‐mediated photodegradation is applied for the completely destroying PFAS in the sorbent regeneration eluent.
Hao Yu   +5 more
wiley   +1 more source

NAD+ Metabolism Licenses Zygotic Genome Activation via PARP7‐Mediated ADP‐Ribosylation of UHRF1 in Mouse Early Embryos

open access: yesAdvanced Science, EarlyView.
This study uncovers a metabolic‐epigenetic axis licensing zygotic genome activation (ZGA) in mouse embryos. A developmental decline in NAD+ levels activates PARP7, which mono‐ADP‐ribosylates and stabilizes UHRF1. This modification promotes the establishment of permissive histone acetylation marks, thereby facilitating timely ZGA.
Guangyi Cao   +13 more
wiley   +1 more source

Targeting a Myeloid–Regulatory B Cell Network Reverses Immune Paralysis in Periprosthetic Joint Infections

open access: yesAdvanced Science, EarlyView.
Periprosthetic joint infection establishes a sophisticated immunosuppressive network between CXCR4+ PMN‐MDSCs and Bregs, inducing profound CD8+ T cell paralysis. Alendronate effectively disrupts this CXCR4+ PMN‐MDSC–Breg axis by targeting STAT3, thereby restoring local immune surveillance.
Jintao Wu   +9 more
wiley   +1 more source

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