This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li +8 more
wiley +1 more source
Ofiuroideos del Cretácico Inferior de Patagonia: primer registro fósil articulado para el Mesozoico de América del Sur [PDF]
The first articulated remains of ophiuroids for the Mesozoic of South America are described from the Lower Cretaceous of Neuquén Basin, Argentina.
Comerio, Marcos +6 more
core +2 more sources
Objective We evaluated the role of 25‐hydroxyvitamin D (25[OH]D), prednisone, and other risk factors for bone mineral density (BMD) loss and osteoporosis in systemic lupus erythematosus (SLE). Methods We calculated the association between 25(OH)D levels and other potential risk factors and BMD measures (spine T scores) and osteoporosis (defined as a T ...
Nima Madanchi +4 more
wiley +1 more source
Presencia de Indio en sistemas epitermales polimetálicos de Patagonia [PDF]
Fil: Jovic, Sebastián Miguel. Universidad Nacional de La Plata. Facultad de Ciencias Naturales y Museo. Instituto de Recursos Minerales; ArgentinaFil: Lopez, Luciano. Universidad Nacional de La Plata. Facultad de Ciencias Naturales y Museo.
Guido, Diego Martín +6 more
core
Carlhintzeite, Ca2AlF7•H2O, from the Gigante granitic pegmatite, Córdoba province, Argentina: Description and crystal structure [PDF]
Carlhintzeite, Ca2AlF7•H2O, has been found at the Gigante pegmatite, Punilla Department, Córdoba Province, Argentina. It occurs as colourless prismatic crystals up to 0.8 mm long, ubiquitously twinned on {001}.
Colombo, Fernando +2 more
core +1 more source
Associations of Rheumatoid Arthritis Disease Activity With Frailty Over Five Years of Follow‐up
Objective To evaluate whether rheumatoid arthritis (RA) disease activity is associated with frailty both in cross‐section and longitudinally. Methods Participants within the Veterans Affairs Rheumatoid Arthritis (VARA) registry enrolled from 2003 to 2022 were included.
Courtney N. Loecker +14 more
wiley +1 more source
Evidencias de una zona de cizalla dúctil en el basamento pre-pérmico de la región de Bahía Laura, Macizo del Deseado, Santa Cruz [PDF]
Fil: Giocosa, Raúl. SEGEMAR-IGRM, Comodoro Rivadavia (9003)Fil: López, Ramiro. Instituto de Recursos Minerales, La PlataFil: Guido, Diego Martín.
Giocosa, Raúl +2 more
core
Harnessing Fungal Biowelding for Constructing Mycelium‐Engineered Materials
Mycelium‐bound composites (MBCs) offer low‐carbon alternatives for construction, yet interfacial bonding remains a critical challenge. This review examines fungal biowelding as a biocompatible adhesive, elucidating mycelium‐mediated interfacial mechanisms and their role in material assembly. Strategies to optimize biowelding are discussed, highlighting
Xue Brenda Bai +2 more
wiley +1 more source
Características mineraloquímicas e implicancias genéticas de la Vesubianita del Skarn Loma Marcelo, sierras australes de Buenos Aires [PDF]
Fil: Ballivián Justiniano, Carlos A.. Instituto de Recursos Minerales (INREMI). Facultad de Ciencias Naturales y Museo. Universidad Nacional de La Plata; ArgentinaFil: Lajoinie, María Florencia. Instituto de Recursos Minerales (INREMI).
Ballivián Justiniano, Carlos A. +4 more
core

