Three‐quarters of patients who underwent ICD/CRT‐D implantation for secondary prevention received appropriate ICD therapy and survived at least 1 year thereafter. In contrast, patients aged 70 or older and those with a history of ventricular fibrillation (VF) were less likely to benefit from secondary prevention with an ICD.
Rie Akagawa +9 more
wiley +1 more source
A novel mineralocorticoid receptor blocker, CS-3150, improves insulin resistance and reduces inflammation in db/db mice. [PDF]
Bavuu O +7 more
europepmc +1 more source
Tailoring Mineralocorticoid Receptor Antagonist Therapy in Heart Failure Patients: Are We Moving Towards a Personalized Approach? [PDF]
João Pedro Ferreira +4 more
openalex +1 more source
ABSTRACT Objective and Background Early identification of adrenal insufficiency (AI) during immune‐checkpoint inhibitors (ICIs) is crucial to prevent life‐threatening consequences; however, the diagnosis is challenging. Design, Patients and Measurement In this prospective observational study, ICI‐treated cancer patients with morning serum cortisol (SC)
Alice Nervo +6 more
wiley +1 more source
Efficacy and safety of mineralocorticoid receptor antagonists in heart failure: a meta-analysis of randomized controlled trials. [PDF]
Wu J, Pei Y, Wu J, Huang Y.
europepmc +1 more source
ABSTRACT Objective Successful adrenal venous sampling (AVS) is traditionally assessed using the ratio of cortisol in adrenal to peripheral venous plasma to calculate the selectivity index. With mass spectrometry other steroids can be simultaneously measured that may improve numbers of apparent successful sampling procedures.
Francesco Alessi +14 more
wiley +1 more source
Renin-guided therapy with mineralocorticoid receptor antagonists in primary aldosteronism: feasibility study (RETAME-PA) - a clinical research protocol for a randomised controlled trial. [PDF]
Merabtine A +5 more
europepmc +1 more source
Steroids:Modulators of inflammation and immunity [PDF]
Chapman, Karen E, Odermatt, Alex
core +1 more source
Eplerenone improves kidney function and cardiac performance in obese male mice
Abstract Aims Renin‐angiotensin‐aldosterone system (RAAS) activation mediates obesity‐associated cardiorenal dysfunction. Due to an incomplete understanding of the molecular mechanisms, the clinical use of RAAS antagonism in obesity‐associated cardiometabolic complications remains uncertain.
Ayman K. Banah +8 more
wiley +1 more source
Addressing unmet needs for chronic kidney disease treatment in type 1 diabetes: A review
Abstract Chronic kidney disease (CKD) is a serious complication occurring in nearly one of three people with type 1 diabetes (T1D). Major therapeutic advances have been made in the management of CKD for people with type 2 diabetes (T2D), thereby improving their kidney, cardiovascular, and survival outcomes.
Katherine R. Tuttle +3 more
wiley +1 more source

