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Steroids, 1996
Pseudohypoaldosteronism was first described in 1958 by Cheek and Perry, who reported an infant with severe salt wasting in the absence of any renal or adrenal defect. Since then several reports have described patients affected by symptoms consistent with resistance to mineralocorticoid action.
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Pseudohypoaldosteronism was first described in 1958 by Cheek and Perry, who reported an infant with severe salt wasting in the absence of any renal or adrenal defect. Since then several reports have described patients affected by symptoms consistent with resistance to mineralocorticoid action.
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Evidence for Cortisol as the mineralocorticoid in the syndrome of apparent mineralocorticoid excess
Journal of Endocrinological Investigation, 1992The hypothesis that cortisol is the functioning mineralocorticoid in the syndrome of apparent mineralocorticoid excess was tested by suppressing its secretion with dexamethasone. The subjects were two siblings with the type 2 form of this syndrome in which the defect in the peripheral metabolism of cortisol lies predominantly in ring A reduction but ...
TEDDE, Rinaldo +3 more
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Trends in Endocrinology & Metabolism, 1998
Adrenal Glands, Vascular System and Hypertension Edited by G.P. Vinson and D.C. Anderson. Bristol, UK, Society for Endocrinology, $95.00/ pound50.00 (312 pages), ISBN 1-898099-07-3.
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Adrenal Glands, Vascular System and Hypertension Edited by G.P. Vinson and D.C. Anderson. Bristol, UK, Society for Endocrinology, $95.00/ pound50.00 (312 pages), ISBN 1-898099-07-3.
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Disorders of mineralocorticoid synthesis
Best Practice & Research Clinical Endocrinology & Metabolism, 2001Abnormalities of mineralocorticoid synthesis and/or metabolism profoundly affect the regulation of electrolyte and water balance and of blood pressure. Characteristic changes in extracellular potassium, sodium and hydrogen ion concentrations are usually diagnostic. Serious deficiency may be acquired, for example in Addison's disease, or inherited.
J M, Connell, R, Fraser, E, Davies
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The Multifaceted Mineralocorticoid Receptor
Comprehensive Physiology, 2014Abstract The primary adrenal cortical steroid hormones, aldosterone, and the glucocorticoids cortisol and corticosterone, act through the structurally similar mineralocorticoid (MR) and glucocorticoid receptors (GRs). Aldosterone is crucial for fluid, electrolyte, and hemodynamic homeostasis and tissue repair; the
Elise, Gomez-Sanchez +1 more
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Mineralocorticoid receptor antagonists
Current Hypertension Reports, 2007With an increasingly aging population, the need for effective treatment of cardiovascular diseases (eg, heart failure, hypertension, and ischemic heart disease) cannot be overemphasized. The vital importance of mineralocorticoid receptor antagonists for treating cardiovascular conditions has only been appreciated in the last decade. The re-emergence of
Parthasarathy, Hari Krishnan +1 more
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Monogenic mineralocorticoid hypertension
Best Practice & Research Clinical Endocrinology & Metabolism, 2006Monogenic mutations leading to excessive activation of the mineralocorticoid pathway result, almost always, in suppressed renin and hypertension in adult life and sometimes in hypokalaemia and alkalosis, which can be severe. In most of these syndromes, precise molecular changes in specific steroidogenic or effector genes have been identified ...
Stowasser, Michael, Gordon, Richard D.
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Apparent mineralocorticoid excess
The Journal of Steroid Biochemistry and Molecular Biology, 1995Apparent mineralocorticoid excess is a syndrome reflecting the absent or impaired activity of the enzyme 11β-hydroxysteroid dehydrogenase Type 2. It may be mild when the mutant enzyme retains some activity, or severe when activity is absolutely or essentially absent.
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Mineralocorticoids and blood pressure
Current Opinion in Nephrology and Hypertension, 1994Recent observations suggest that the syndrome of mineralocorticoid excess, primary aldosteronism, may be more common than has been previously believed. Enhanced detection of this syndrome has been simplified by the development of sensitive screening techniques.
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Mineralocorticoids and Hypertension
American Journal of Nephrology, 2008O B, Holland, C, Gomez-Sanchez
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