Results 141 to 150 of about 1,156,762 (339)

The Nepticulidae of Malta (Lepidoptera) [PDF]

open access: yes, 2011
Three species of Nepticulidae are recorded for the fi rst time from the Maltese Islands. Acalyptris minimella, Ectoedemia euphorbiella, and Parafomoria pseudocistivora are added to the previously recorded Stigmella aurella.
Nieukerken, Erik J. van, Zerafa, Michael
core  

Targeting Microglial CD49a Inhibits Neuroinflammation and Demonstrates Therapeutic Potential for Parkinson's Disease

open access: yesAdvanced Science, EarlyView.
This study shows that integrin receptor CD49a (Itga1 gene) is significantly upregulated in hyperactivated microglia and microglia‐specific knockdown of Itga1 rescues neuroinflammation and neurodegeneration in a chronic Parkinson's disease (PD) model by targeting PGAM5‐mediated mitochondrial dysfunction and NLRP3 activation. Targeted inhibition of CD49a
Huanpeng Lu   +6 more
wiley   +1 more source

Regional Priority Setting in Queensland: A multi-criteria evaluation framework. [PDF]

open access: yes
Consultancy report for the Queensland Department of Natural Resources and Mines.audit;Australia;Queensland;natural resources ...
Stefan Hajkowicz (Ed)
core  

Halorotetin B, A Novel Terpenoid Compound Derived from Marine Ascidian, Suppresses Tumor Growth by Targeting the Cell Cycle Regulator UBE2C

open access: yesAdvanced Science, EarlyView.
Halorotetin B, a novel small‐molecule terpenoid identified from an edible marine ascidian, exhibits strong anti‐tumor activity both in vitro and in vivo through direct targeting UBE2C to induce tumor cell cycle arrest and then lead tumor cell senescence. As a newly discovered UBE2C inhibitor, Halorotetin B can serve as a novel potential cell senescence
Shanhao Han   +6 more
wiley   +1 more source

LANDSAT inventory of surface-mined areas using extendible digital techniques [PDF]

open access: yes
Multispectral analysis of LANDSAT imagery provides a rapid and accurate means of identification, classification, and measurement of strip-mined surfaces in Western Maryland.
Anderson, A. T.   +2 more
core   +2 more sources

The Microbiota Shapes Central Nervous System Myelination in Early Life

open access: yesAdvanced Science, EarlyView.
Gut microbiota shapes brain development by regulating myelination and glial cell maturation in early life. Using germ‐free (GF) mice and zebrafish, this study reveals sex‐ and age‐dependent effects on myelin growth, integrity, and related gene expression.
Caoimhe M. K. Lynch   +13 more
wiley   +1 more source

Connexin43 Deficiency Leads to Ventricular Arrhythmias by Reprogramming Proline Metabolism

open access: yesAdvanced Science, EarlyView.
The study demonstrated that connexin43 (Cx43) knockout caused arrhythmic phenotype and decreased proline content in vitro and in vivo. Mechanistically, Cx43 interacts with the amino acid transporter SNAT2 (sodium‐dependent neutral amino acid transporter), and its deficiency disrupts proline transport and metabolism.
Hangying Ying   +8 more
wiley   +1 more source

The Regulatory Role of Iron Transporter SLC39A13 in Liver Fibrosis

open access: yesAdvanced Science, EarlyView.
SLC39A13/ZIP13, a newly discovered intracellular iron transporter, delivers iron to the ER/Golgi to catalyze procollagen hydroxylation during collagen maturation. Here, we systematically characterize the cell type‐specific functions of ZIP13 across distinct hepatic cell populations, and identify hepatic stellate cell‐specific ZIP13 as a promising and ...
Shanshan Guo   +5 more
wiley   +1 more source

A Systematic Review of Occupational Health and Safety in Mining Sector in Pakistan

open access: yesInternational Journal of Economic and Environment Geology
The mining sector in Pakistan is regarded as a hazardous occupation due to its dangerous nature and working environment, which frequently results in deadly accidents.
Maqsooda Barozai, Sanaullah Panezai
doaj   +1 more source

Benefits of the Southcentral Rail Extension to the Municipality of Anchorage [PDF]

open access: yes, 2010
The proposed Southcentral rail extension to Port MacKenzie is likely to generate significant economic benefits for the residents of Anchorage. These benefits are due to a combination of reduced transport costs, the ability to ship bulk commodities over
Colt, Steve, Szymoniak, Nick
core  

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