Results 41 to 50 of about 527,049 (245)

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Perawatan ortodonti kamuflase pada maloklusi skeletal kelas II dengan penjangkaran mini implant ortodonti, dengan system MBT

Camouflage orthodontic treatment in class II skeletal malocclusion with the orthodontic mini implant by the MBT system

Jurnal Kedokteran Gigi Universitas Padjadjaran, 2022
ABSTRAK Pendahuluan: Maloklusi kelas II skeletal memiliki gambaran klinis yang khas yang sulit diubah secara ortodonti konvensional, bahkan terkadang harus dikelola secara ortodonti bedah.
Rani Setyawati Moekti, Haru Setyo Anggani   +1 more
doaj   +1 more source

The effect of coating chitosan on Porphyromonas gingivalis biofilm formation in the surface of orthodontic mini-implant

Journal of Advanced Pharmaceutical Technology & Research, 2021
Infection is the main problem for the failure of orthodontic mini-implant. Modern prevention of infection is now focused on local antibacterial coatings on implant devices. Chitosan is biocompatible and has antibacterial properties.
Haru Setyo Anggani, Renaldo Guruh Perdana, Erwin Siregar, Endang Winiati Bachtiar   +3 more
doaj   +1 more source

Análise histomorfológica e histomorfométrica de mini-implantes para ancoragem ortodôntica imediata e precose [PDF]

, 2005
Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde . Programa de Pós-Graduação em Odontologia.O objetivo do presente estudo foi avaliar a taxa de sobrevivência e a resposta óssea de mini-implantes submetidos a forças ...
Freire, José Nilo de Oliveira
core  

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

O uso de mini-implantes como ancoragem ortodôntica [PDF]

, 2011
TCC (graduação) - Universidade Federal de Santa Catarina, Universidade Federal de Santa Catarina, Centro de Ciências da Saúde, Curso de Odontologia.A ancoragem ortodôntica é decisiva para o sucesso do tratamento ortodôntico, onde dispositivos intra e ...
Schlickmann, Sérgio
core  

The Effect of Mini Dental Implant Number on Mandibular Overdenture Retention and Attachment Wear [PDF]

, 2023
Purpose. Evaluate the effect of different mini-implant numbers on overdenture retention and evaluate attachment wear following one year of simulated placement/removal. Material and Methods.
Rafif Alshenaiber, Barclay, Craig, Nick Silikas, Craig Barclay, Silikas, Nick, Alshenaiber, Rafif   +5 more
core   +1 more source

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

Molecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh, Ji Yun Jang, Yoon Jeon, Gi‐Cheon Kim, Hwanho Lee, Jooyoung Lee, Ju‐Hwa Kim, Hakhyun Kim, Minjee Kim, Ho‐Keun Kwon, Ho Lee, Hyun Seok Kim   +11 more
wiley   +1 more source