Results 51 to 60 of about 15,194 (223)

A new strategy for enhancing imputation quality of rare variants from next-generation sequencing data via combining SNP and exome chip data [PDF]

, 2015
Background: Rare variants have gathered increasing attention as a possible alternative source of missing heritability. Since next generation sequencing technology is not yet cost-effective for large-scale genomic studies, a widely used alternative ...
Abecasis, G.R. (Gonçalo), Altshuler, D. (David), Asimit, J.L. (Jennifer L.), Atzmon, G. (Gil), Barber, M. (Mathew), Barzilai, A. (Ari), Beer, N.L. (Nicola L.), Bell, G.I. (Graeme I.), Below, J. (Jennifer), Blackwell, T. (Tom), Blangero, J. (John), Boehnke, M. (Michael), Bowden, D.W. (Donald W.), Burtt, N.P. (Noël), Chambers, J.C. (John), Chen, H. (Han), Chen, P. (Ping), Chines, P.S. (Peter), Cho, Y.S. (Yoon Shin), Choi, S. (Sungkyoung), Churchhouse, C. (Claire), Cingolani, P. (Pablo), Cornes, B.K. (Belinda), Cox, N.J. (Nancy), Day-Williams, A.G. (Aaron), De Almeida, M.A.A. (Marcio), Duggirala, A. (Aparna), Dupuis, J. (Josée), Dyer, T. (Thomas), Feng, S. (Shuang), Fernandez-Tajes, J. (Juan), Ferreira, T. (Teresa), Fingerlin, T.E. (Tasha E.), Flannick, J. (Jason), Florez, J.C. (Jose), Fontanillas, P. (Pierre), Frayling, T.M. (Timothy), Fuchsberger, C. (Christian), Gamazon, E. (Eric), Gaulton, K. (Kyle), Ghosh, S. (Saurabh), Glaser, B. (Benjamin), Gloyn, A.L. (Anna), Grossman, R.L. (Robert L.), Grundstad, J. (Jason), Hanis, C. (Craig), Heath, A. (Allison), Highland, H. (Heather), Horikoshi, M. (Momoko), Huh, I.-S. (Ik-Soo), Huyghe, J.R. (Jeroen R.), Ikram, M.K. (Kamran), Im, H.K. (Hae Kyung), Jablonski, K.A. (Kathleen), Jun, Y. (Yang), Kato, N. (Norihiro), Kim, B.-J. (Bong-Jo), Kim, B.-J. (Bong-Jo), Kim, J. (Jayoun), Kim, Y.J. (Young Jin), Kim, Y.J. (Young Jin), King, C.R. (C. Ryan), Kooner, J.S. (Jaspal S.), Kwon, M.-S. (Min-Seok), Laakso, M. (Markku), Lam, K.K.-Y. (Kevin Koi-Yau), Lee, J. (Jaehoon), Lee, J. (Juyoung), Lee, J. (Juyoung), Lee, S. (Selyeong), Lee, S. (Sungyoung), Lehman, D.M. (Donna M.), Li, H. (Heng), Lindgren, C.M. (Cecilia), Liu, X. (Xuanyao), Livne, O.E. (Oren E.), Locke, A.E. (Adam E.), Mahajan, A. (Anubha), Maller, J.B. (Julian B.), Manning, A.K. (Alisa K.), Maxwell, T.J. (Taylor J.), Mazoure, A. (Alexander), McCarthy, M.I. (Mark), Meigs, J.B. (James B.), Min, B. (Byungju), Mohlke, K.L. (Karen), Morris, A.P. (Andrew), Musani, S. (Solomon), Nagai, Y. (Yoshihiko), Ng, M.C.Y. (Maggie C.Y.), Nicolae, D. (Dan), Oh, S. (Sohee), Palmer, N.D. (Nicholette), Park, T. (Taesung), Park, T. (Taesung), Pollin, T.I. (Toni I.), Prokopenko, I. (Inga), Reich, D. (David), Rivas, M.A. (Manuel), Scott, L.J. (Laura), Seielstad, M. (Mark), Sim, X. (Xueling), Sladek, R. (Rob), Smith, P. (Philip), Tachmazidou, I. (Ioanna), Tai, E.S. (Shyong), Teo, Y.Y. (Yik Ying), Teslovich, T.M. (Tanya M.), Torres, J. (Jason), Trubetskoy, V. (Vasily), Willems, S.M. (Sara), Williams, A.L. (Amy L.), Wilson, J.G. (James), Wiltshire, S. (Steven), Won, S. (Sungho), Wood, A.R. (Andrew), Xu, W. (Wang), Yoon, J. (Joon), Zawistowski, M. (Matthew), Zeggini, E. (Eleftheria), Zhang, W. (Weihua), Zöllner, S. (Sebastian)   +121 more
core   +1 more source

Stoic attitude in patients with cancer from the NEOcoping study: cross-sectional study [PDF]

, 2022
Aim: Stoicism has been applied to describe a wide range of behaviors in the face of disease and influences an individual's use of coping strategies. This study tested the relationship between stoicism and social support, optimism, psychological distress,
Calderón Garrido, Caterina, Carmona Bayonas, Alberto, Carrión-Galindo, Rafael, Gil-Raga, Mireia, Gómez, David, Hernández, Raquel, Higuera, Oliver, Jiménez Fonseca, Paula, Muñoz, Maria del Mar, Pacheco-Barcia, Vilma, Rogado, Jacobo, Valero, María   +11 more
core   +2 more sources

LMO7 Suppresses Tumor‐Associated Macrophage Phagocytosis of Tumor Cells Through Degradation of LRP1

Advanced Science, EarlyView.
LMO7 in tumor‐associated macrophages suppresses phagocytosis of tumor cells and limits cytotoxic T lymphocytes infiltration, fostering tumor progression. Mechanistically, LMO7 mediates the ubiquitination and degradation of the phagocytic receptor LRP1, impairing its ability to engulf tumor cells and driving macrophages toward an antitumor phenotype ...
Mengkai Li, Tao Wang, Yuwen Zhong, Zhiming Wang, Wei Li, Zejian Wang, Xinyi Yang, Yu Qiao, Jianfeng Xiang, Wei Gu, Zishu Wang, Lei Sun, Feng Qian   +12 more
wiley   +1 more source

Adaptation to cancer among Polish patients with cervical cancer in relation to illness acceptance, life satisfaction, and dispositional optimism

Ginekologia Polska
OBJECTIVES: Activating positive coping strategies for cancer in the face of a new, changed health situation, good acceptance of the illness, life satisfaction, and dispositional optimism influence the quality of life of patients and are key factors ...
Weronika Biber, Malgorzata Fras, Maria Ciechacka, Mahdi Al-Jeabory, Ewelina Bak   +4 more
doaj   +1 more source

Sphingomonas paucimobilis‐Driven Epithelial–Endothelial Transition in Adenomyosis Pathogenesis

Advanced Science, EarlyView.
This study identifies epithelial–endothelial transition (EET) as a novel adenomyosis pathogenic mechanism driven by Sphingomonas paucimobilis colonization. Systematic inhibitor experiments validate a TNFα→NF‐κB→MMP signaling cascade essential for EET. Critically, bacterial culture supernatant fails to induce pathological changes, demonstrating viable ...
Peigen Chen, Hao Shi, Junxian He, Ziyu Liu, Yuanyuan Zhu, Xiaoyan Liang, Guihua Liu, Xing Yang   +7 more
wiley   +1 more source

Design of miniprotein inhibitors targeting complement C9 to block membrane attack complex assembly

Nature Communications
The abnormal formation of the membrane attack complex (MAC) is intrinsically linked to a range of acute and chronic immune diseases. The insertion of complement C9 into the membrane is the final step and kinetic bottleneck of MAC formation.
Min Li, Ningning Wang, Xiaoyan Fu, Gege Wei, Ze Zhang, Yanghan Yu, Tianshui Xue, Yifei Zhao, Jinheng Pan, Dongfeng Wang, Meifang Liu, Yong Li, Jinbao Tang, Longxing Cao, Zhaocheng Jian, Shujuan Liang, Bowen Yu   +16 more
doaj   +1 more source

How to spice up a breakfast cereal or The translation of culturally bound referential items in “The bluest eye” by Toni Morrison and “Vineland” by Thomas Pynchon [PDF]

, 2013
This article will attempt to suggest translation procedures necessary to translate culturally bound items in the referential level of a literary work illustrated with examples from two novels: “The Bluest Eye” by Toni Morrison and “Vineland” by Thomas ...
Barciński, Łukasz
core  

PEPITEM Regulates the Synovial Microenvironment During Immune‐Mediated Inflammatory Arthritis to Limit Disease

Arthritis &Rheumatology, EarlyView.
Objective Here we investigate the status of the adiponectin–PEPITEM pathway in early, treatment naive rheumatoid arthritis (RA) and psoriatic arthritis (PsA) and the therapeutic efficacy of PEPITEM administration in preclinical models. Methods Peripheral blood was isolated from patients with clinical suspect arthralgia and suspected inflammatory ...
Mussarat Wahid, Samuel Kemble, Oladimeji Abudu, Anella Saviano, Christopher Mahony, Jonathan W. Lewis, Thomas A. Nicholson, Anna Schettino, Noemi Marigliano, Kathryn Frost, Jenefa Begum, Alyssa M. Urbanowski, Marion Limo, Rakesh Jha, Sandra Martinez Jarquin, Laleh Pezhman, Abbie E. A. Degan, Amy E. Anderson, Charlotte G. Smith, Armaiti Batki, Holly Adams, Francesco Caso, Raffaele Scarpa, Iain McInnes, Stefan Siebert, Arthur G. Pratt, Andrew Filer, Karim Raza, Adam P. Croft, Myriam Chimen, Felicity de Cogan, G. Ed Rainger, Asif J. Iqbal, Francesco Maione, Helen M. McGettrick   +34 more
wiley   +1 more source

The CMS DAQ Pinball Machine [PDF]

EPJ Web of Conferences, 2020
We present an interactive game for up to seven players that demonstrates the challenges of on-line event selection at the Compact Muon Solenoid (CMS) experiment to the public.
Cornu Cynthia, Deldicque Christian, Gladki Maciej, Holzner André, Perrenoud Lydie, Reis Thomas, Sakulin Hannes, Vougioukas Michail   +7 more
doaj   +1 more source

Mini‐MACS: development of the Manual Ability Classification System for children younger than 4 years of age with signs of cerebral palsy [PDF]

Developmental Medicine & Child Neurology, 2016
AimTo develop the Mini‐Manual Ability Classification System (Mini‐MACS) and to evaluate the extent to which its ratings are valid and reliable when children younger than 4 years are rated by their parents and therapists.MethodThe Mini‐MACS was created by making adjustments to the MACS.
Ann-Christin, Eliasson, Anna, Ullenhag, Ulla, Wahlström, Lena, Krumlinde-Sundholm   +3 more
openaire   +2 more sources