Results 221 to 230 of about 2,823,725 (275)

Probing the Energy Landscape of α‐Synuclein Amyloid Fibril Formation by Systematic K‐to‐Q Mutagenesis

Advanced Science, EarlyView.
We use lysine‐to‐glutamine mutations to study the effect of electrostatics on the kinetics and thermodynamics of alpha‐synuclein amyloid fibril formation. We find that mutational effects map on their structural context within fibrils and identify residues that modulate the energy landscape of alpha‐synuclein self‐assembly. Our work outlines a scalable,
Antonin Kunka, Azad Farzadfard, Jacob Aunstrup Larsen, Rasmus Krogh Norrild, Federica Saraceno, Celia Fricke, Hossein Mohammad‐Beigi, Ahmed Sadek, Jonas Folke, Susana Aznar, Alexander K. Buell   +10 more
wiley   +1 more source

Assessment of the efficacy of ChatGPT responses to bacterial species-specific questions in microbiology. [PDF]

Access Microbiol
Manushi Dinasha WD, Nissanka NMTA, Wickramasinghe CP, Fernando WPPD, Perera V, Gunatilake HGD.   +5 more
europepmc   +1 more source

Engineered Transformer Base Editor with Enhanced Editing Efficiency

Advanced Science, EarlyView.
A highly efficient transformer base editor system achieves robust genomic editing in a humanized mouse model. This work establishes a versatile and translatable platform, opening new avenues for precision gene therapy. ABSTRACT Canonical cytosine base editors (CBEs) achieve precise C‐to‐T conversions without inducing DNA double‐strand breaks (DSBs ...
Bowen Chen, Letong Liang, Rui Xu, Tianyi Wang, Hongyan Chen, Daru Lu   +5 more
wiley   +1 more source

Effects of swimming on cognitive and health outcomes in older adults and insights into participation facilitators and barriers: a systematic review. [PDF]

Front Med (Lausanne)
Jaana M, Cruise D, Georges C.
europepmc   +1 more source

Maxillary foreign body management in odontogenic sinusitis: an algorithm based on a single centre experience. [PDF]

Front Oral Health
Sabatino L, Lopez MA, Valentini M, Mattaroccia M, Iafrati F, Di Giovanni S, Moffa A, Casale M.   +7 more
europepmc   +1 more source

Accuracy, readability, and bias of GPT-4o mini responses to oculoplastic patient questions. [PDF]

Front Ophthalmol (Lausanne)
Henry T, Staes G, Russell A, Richards-Walker NQ.   +3 more
europepmc   +1 more source

A framework for extraction of clinical information from radiological mammography reports using large language models and retrieval augmented generation. [PDF]

BMC Med Inform Decis Mak
Godoy E, Ferrari J, Lazo S, Pacheco C, Mellado D, Saez A, Chabert S, Salas R.   +7 more
europepmc   +1 more source

Impact of 15 years of social, political and economic shocks on population mental health in the UK: a longitudinal, Bayesian quasi-experimental analysis. [PDF]

BMJ Ment Health
Jeffery A, Gascoigne C, Rotous I, Yu X, Geneletti S, Baio G, Blangiardo M, Kirkbride JB.   +7 more
europepmc   +1 more source

Amine-rich cross-linking templates enabling toughened self-assembled monolayer for stable perovskite solar modules. [PDF]

Sci Adv
Zhang Z, Chen S, Peng C, Xu Y, Wang S, Li W, Zheng Y, Wang W, Du S, Zhou F, Xin H, Li S, Zhao X, Wang T, Ni Z, Yu Z.   +15 more
europepmc   +1 more source