Results 131 to 140 of about 13,793 (230)
Exploring and Targeting the Connection of Iron and Copper Homeostasis to Neurodegenerative Diseases
MedComm, Volume 7, Issue 6, June 2026.Iron and copper dyshomeostasis, along with their interactions with key intrinsically disordered proteins (e.g., Aβ, tau, α‐synuclein) have a strong implication in the onset and progression of neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's disease (PD), Prion diseases (PrDs), Huntington's disease (HD), Wilson's disease (WD),
Xin Liu +9 more
wiley +1 more source
MedComm, Volume 7, Issue 6, June 2026.A bioartificial liver (BAL) integrating GGTA1‐knockout porcine hepatocytes and R‐spondin1‐overexpressing endothelial organoids was tested using plasma from patients with acute‐on‐chronic liver failure (ACLF). The BAL system actively modulates amino acid and lipid metabolism, enhances detoxification, partially restores overall metabolic balance, and ...
Yuting He +8 more
wiley +1 more source
Encephalopathy: Cause, Pathogenesis, and Treatment
MedComm, Volume 7, Issue 6, June 2026.Various encephalopathies (sepsis‐associated, hepatic, hypoxic–ischemic, diabetic, uremic, toxic) have incompletely elucidated pathogenesis, which severely restricts targeted therapy development. Small molecule drugs show unique multitarget potential but face toxicity, poor blood–brain barrier penetration and unclear specificity.
Shimeng Lv +7 more
wiley +1 more source
Aging Cell, Volume 25, Issue 6, June 2026.A noninvasive biomarker–based Liver Aging Index accurately predicts liver‐related events and mortality across diverse populations, offering a practical and generalizable tool with strong potential for clinical and public health application. ABSTRACT Biological aging is a key determinant of liver disease and mortality, but there is little evidence on ...
Zhiyu Wu +38 more
wiley +1 more source
Alcohol, Clinical and Experimental Research, Volume 50, Issue 6, June 2026.In a randomized, double‐blind study of individuals with alcohol use disorder, high‐dose baclofen (75 mg/day) compared with placebo was associated with differences in resting‐state functional connectivity, with higher connectivity in reward and stress‐related regions and lower connectivity in attentional and salience networks.
Warren B. Logge +5 more
wiley +1 more source
Association of GLP‐1 Receptor Agonists With Hepatic Decompensation in the All of Us Research Program
Diabetes, Obesity and Metabolism, Volume 28, Issue 6, Page 4837-4846, June 2026.ABSTRACT Aims To evaluate the association between glucagon‐like peptide‐1 receptor agonist (GLP‐1RA) initiation and the risk of hepatic decompensation compared with dipeptidyl peptidase 4 inhibitors (DPP4is) in a racially and ethnically diverse cohort of adults with Type 2 diabetes.
Inyoung Hwang, Yun Kim, Sang Won Lee
wiley +1 more source
Diabetes, Obesity and Metabolism, Volume 28, Issue 6, Page 5029-5042, June 2026.ABSTRACT Aims The burden of chronic liver disease (CLD) is increasing. This study aims to identify protein markers for CLD and its progression, and develop a protein‐based risk prediction model. Materials and Methods We used proteome‐wide Mendelian randomization (MR), Bayesian colocalization and summary‐data‐based MR with proteomic data from deCODE ...
Xinxuan Li +9 more
wiley +1 more source
Health Expectations, Volume 29, Issue 3, June 2026.ABSTRACT Background Vascular liver diseases (VLDs) predominantly affect young adults and require lifelong monitoring. The health‐related quality of life (HRQoL) of patients with VLDs is deteriorated, with high levels of fatigue and depressive symptoms, but their lived experience and unmet needs remain unknown.
Anouck Alary +17 more
wiley +1 more source
A Framework for Emergency Department–Integrated Hepatitis C Test‐and‐Treat in the United States
Journal of Viral Hepatitis, Volume 33, Issue 6, June 2026.ABSTRACT Despite the availability of curative, direct‐acting antiviral therapy, hepatitis C virus elimination remains incomplete. Losses across the care cascade continue to limit impact, from initial diagnosis to sustained virologic response. Fewer than 1/3 of individuals ultimately achieve cure. These gaps reflect a delivery system that does not align
Saeed S. Graham
wiley +1 more source
Is There a More Practical Way for Screening Minimal Hepatic Encephalopathy? [PDF]
Turk J Gastroenterol, 2023 Değirmencioğlu Tosun Ş +1 more
europepmc +1 more source