Results 131 to 140 of about 1,438,673 (245)

Shikonin: From Biosynthesis and Pharmacological Mechanisms to Translational Safety and Drug Delivery

ChemBioChem, Volume 27, Issue 21, 12 November 2026.
Shikonin, biosynthesised in Boraginaceae roots from phenylalanine‐derived PHB and isoprenoid GPP, modulates redox balance, cellular stress, signalling pathways, and regulated cell death. Preclinical studies support diverse pharmacological activities, while nanocarriers improve dispersion and delivery.
Namini Joshi, Prabhakar Semwal, Balwant Rawat, Ravendra Kumar, Mozaniel Santana de Oliveira, Nishant Rai, Janhvi Mishra Rawat   +6 more
wiley   +1 more source

Ceftriaxone‐induced liver injury: Incidence, phenotypic characterization and predictive factors

British Journal of Clinical Pharmacology, Volume 92, Issue 11, Page 3874-3885, November 2026.
Introduction Ceftriaxone is a widely used third‐generation cephalosporin in hospitalized patients. Although generally considered safe, it has been associated with hepatobiliary complications and emerging reports of drug‐induced liver injury (DILI). However, data on its true incidence, phenotypic patterns, and predictors remain limited. This study aimed
Mohamed Hatem, Mohannad N. AbuHaweeleh, Humam Emad Rajha, Mhd Osama Rahhal, Ahmad Hamdan, Lina Naseralallah   +5 more
wiley   +1 more source

Massive Pleural Synovial Sarcoma Presenting With Obstructive Shock

Clinical Case Reports, Volume 14, Issue 11, November 2026.
ABSTRACT Primary pleural synovial sarcoma (PPSS) is an exceptionally rare and aggressive malignancy. We report a massive PPSS characterized by positive TLE1 immunostaining but negative SS18–SSX Fluorescence in situ hybridization (FISH). This case highlights the importance of integrating morphology, immunohistochemistry, and clinical context when ...
Shenda Hou, Meher Binte Ali, Mashal Ali, Ahmed Abdelwahed, Danish Jilani   +4 more
wiley   +1 more source

Hemophagocytic Lymphohistiocytosis in a Patient With Alcohol‐Associated Liver Disease: A Case Report Highlighting Diagnostic Challenges

Clinical Case Reports, Volume 14, Issue 11, November 2026.
ABSTRACT Hemophagocytic lymphohistiocytosis (HLH) is a life‐threatening hyperinflammatory syndrome with nonspecific clinical manifestations that can mimic common conditions in patients with alcohol dependence. Early clinical suspicion and rapid initiation of treatment are essential to prevent fatal outcomes.
Adalis Rivera, Hakan R. Toka, Yasser Samra, Aleena Khan, Kathryn Bower   +4 more
wiley   +1 more source

Therapeutic Reversal of Severe Neuropsychiatric Symptoms in Wilson's Disease: A Case Report

Clinical Case Reports, Volume 14, Issue 11, November 2026.
ABSTRACT Wilsons disease is an autosomal recessive genetic disorder of copper metabolism that results in copper accumulation in liver and other organs. Hepatic manifestation tends to occur earlier than the neurological manifestation. We present a case with psychiatric presentation.
Tshering Penjor, Sangay Dorji, Sonam Wangchuk   +2 more
wiley   +1 more source

Profound Hyperbilirubinemia During Severe Carbon Monoxide Poisoning and Subsequent Multiorgan Failure: A Case Report

Clinical Case Reports, Volume 14, Issue 11, November 2026.
ABSTRACT Carbon monoxide poisoning is classically associated with neurologic and cardiovascular toxicity, while severe exposure may also cause systemic toxic‐hypoxic injury. Profound direct‐predominant hyperbilirubinemia without mechanical biliary obstruction is rarely described.
Marwan Joma, Anwar Zahran, Abdulrahman Karam, Bisher Sawaf, Wasef Sayeh, Thomas Sodeman, Yaseen Alastal   +6 more
wiley   +1 more source

Worsening of cerebral hyperemia by the administration of terlipressin in acute liver failure with severe hepatic encephalopathy [PDF]

, 2004
There is increasing evidence that terlipressin is useful in patients with cirrhosis and hepatorenal syndrome, but there are no data of its use in patients with acute liver failure (ALF) in whom hepatorenal syndrome is common.
Jalan, R., Hayes, P.C., Mookerjee, R.P., Shawcross, D.L., Williams, R., Lee, A., Davies, N.A.   +6 more
core  

Pathogenic Variants in HEPACAM Alter Protein Localization and Interactome in Astrocytes of the Developing Mouse Cortex

Glia, Volume 74, Issue 11, November 2026.
Pathogenic variants alter hepaCAM protein distribution. Astrocyte‐specific hepaCAM TurboID reveals KCNQ2 as a new interaction partner. Pathogenic variants alter hepaCAM association with key transmembrane proteins. ABSTRACT Megalencephalic leukoencephalopathy with subcortical cysts (MLC) is a rare leukodystrophy characterized by early‐onset macrocephaly,
Robert W. Lewis, Breana C. Dogan, Amy L. Stanek, Elliot B. Evans, Madelyn G. Coble, Hayli E. Spence‐Osorio, Karen L. G. Farizatto, Angie L. Mordant, C. Allie Mills, Laura E. Herring, Katherine T. Baldwin   +10 more
wiley   +1 more source

Portosystemic shunts and refractory hepatic encephalopathy: patient selection and current options

, 2019
Cyriac Abby Philips, Sasidharan Rajesh, Philip Augustine, Guruprasad Padsalgi, Rizwan Ahamed The Liver Unit, Cochin Gastroenterology Group, Ernakulam Medical Centre, Cochin, Kerala, India Abstract: Portosystemic shunt (PS) syndrome encompasses a spectrum
Rajesh S, Augustine P, Philips CA, Ahamed R, Padsalgi G   +4 more
core  

A pilot evaluation of a computer-based psychometric test battery designed to detect impairment in patients with cirrhosis

International Journal of General Medicine, 2017
Nicola A Cook,1 Jin Un Kim,1 Yasmin Pasha,1 Mary ME Crossey,1 Adrian J Schembri,2,3 Brian T Harel,2,4 Torben Kimhofer,5 Simon D Taylor-Robinson1 1Liver Unit, Division of Digestive Health, Department of Surgery and Cancer, Imperial College London, London,
Cook NA, Kim JU, Pasha Y, Crossey MME, Schembri AJ, Harel BT, Kimhofer T, Taylor-Robinson SD   +7 more
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