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Real-time immunophenotypic shifts in pediatric B lymphoblastic leukemia providing implications for minimal residual disease detection. [PDF]
Adv Lab MedJaved O +7 more
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2012
Disease relapse remains a major problem in a significant proportion of patients treated for cancer. Molecular monitoring of minimal residual disease (MRD), usually using a real-time quantitative PCR-based approach, is an important tool for risk stratification and prognostication and can be used as a guide for optimizing clinical management in these ...
MUSSOLIN, LARA +2 more
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Disease relapse remains a major problem in a significant proportion of patients treated for cancer. Molecular monitoring of minimal residual disease (MRD), usually using a real-time quantitative PCR-based approach, is an important tool for risk stratification and prognostication and can be used as a guide for optimizing clinical management in these ...
MUSSOLIN, LARA +2 more
+5 more sources
Current Opinion in Hematology, 1995
The study of minimal residual disease has been fueled by the technologic advent of the polymerase chain reaction and basic developments identifying the genetic lesions involved in human malignancies. Thus far advances in identifying, cloning, and the subsequent polymerase chain reaction amplification of relevant genes have outpaced clinical studies ...
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The study of minimal residual disease has been fueled by the technologic advent of the polymerase chain reaction and basic developments identifying the genetic lesions involved in human malignancies. Thus far advances in identifying, cloning, and the subsequent polymerase chain reaction amplification of relevant genes have outpaced clinical studies ...
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Current Opinion in Hematology, 1998
A major limitation in the treatment of malignant disorders is the accurate and sensitive detection of minimal residual disease. It is clear that routine radiographic and pathologic studies are extremely important, however, lacking in sensitivity. Clearly, the goal of minimal residual disease detection is to make individual treatment decisions such that
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A major limitation in the treatment of malignant disorders is the accurate and sensitive detection of minimal residual disease. It is clear that routine radiographic and pathologic studies are extremely important, however, lacking in sensitivity. Clearly, the goal of minimal residual disease detection is to make individual treatment decisions such that
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Managing Minimal Residual Malignant Disease
Oncology, 1986So-called complete remission of acute leukemia and other tumors frequently leaves minimal residual disease cells, sometimes causing an inflammatory response and often relapse. Although the remaining cells often have long generation times or may even be in G0 condition, they may form a new tumor mass.
G, Mathé, P, Reizenstein
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Minimal residual disease in melanoma
Seminars in Surgical Oncology, 2001AbstractA number of specific genes encoding for melanosomal proteins are selectively expressed in melanocytes and melanomas. For detection of circulating melanoma cells, the expression of the tyrosinase gene is most widely used. Several cohorts of melanoma patients from single institutions have been analyzed by various research groups for the presence ...
N, Max, U, Keilholz
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Detection of minimal residual disease
2001Publisher Summary Minimal residual disease (MRD) is defined as the presence of a small number of cancer cells in hematological malignancies usually below 1010 cells (that amount approximately corresponds to 1g of the total cancer cell burden in a human body).
A, Deptala, S P, Mayer
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2009
During the past 30 years, survival rates after allogeneic stem cell transplantation (SCT) have been improved substantially. These improvements have mostly been due to better graft matching using genomic HLA typing, GVHD prophylaxis, infection management, and supportive care [1-3]. The incidence of leukemia relapse and death rates after relapse, however,
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During the past 30 years, survival rates after allogeneic stem cell transplantation (SCT) have been improved substantially. These improvements have mostly been due to better graft matching using genomic HLA typing, GVHD prophylaxis, infection management, and supportive care [1-3]. The incidence of leukemia relapse and death rates after relapse, however,
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Multiple Myeloma Minimal Residual Disease
2016Assessment of minimal residual disease (MRD) is becoming standard diagnostic care for potentially curable neoplasms such as some acute leukemias as well as chronic myeloid and lymphocytic leukemia. Although multiple myeloma (MM) remains as an incurable disease, around half of the patients achieve complete remission (CR), and recent data suggests ...
Bruno, Paiva +2 more
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